Breast cell line dose response to target inhibition measured by high throughput microscopy - Dataset (ID:20136)
Download: Excel (XLSX), Comma-separated (CSV)
| Small Molecule | Cell Line | Drug Concentration | Conc Units | Timepoint | Timepoint Units | Measured pERK (Alexa 488) | Measured p-Rb (Alexa 568) | Alexa Fluor 647 | Measured p-Akt/p-4EBP1/p-S6 (Alexa 647) | Image |
|---|---|---|---|---|---|---|---|---|---|---|
| Torkinib | MCF 10A | 7.5 | nM | 24 | hr | 455.61 | 175.00 | p-S6 | 479.38 | |
| Torkinib | T47D | 7.5 | nM | 6 | hr | 184.86 | 113.82 | p-S6 | 367.66 | |
| Torkinib | T47D | 7.5 | nM | 24 | hr | 144.08 | 65.96 | p-Akt | 33.04 | |
| Torkinib | MCF 10A | 7.5 | nM | 6 | hr | 466.14 | 166.31 | p-S6 | 576.27 | |
| Torkinib | T47D | 7.5 | nM | 6 | hr | 162.62 | 84.08 | p-4EBP1 | 434.94 | |
| Torkinib | MCF 10A | 7.5 | nM | 24 | hr | 362.68 | 177.31 | p-4EBP1 | 160.77 | |
| Torkinib | MCF 10A | 7.5 | nM | 6 | hr | 427.52 | 157.79 | p-Akt | 37.03 | |
| Torkinib | T47D | 7.5 | nM | 6 | hr | 157.46 | 86.43 | p-Akt | 48.47 | |
| Torkinib | AU565 | 7.5 | nM | 6 | hr | 383.95 | 66.61 | p-S6 | 58.91 | |
| Torkinib | HCC1954 | 7.5 | nM | 24 | hr | 296.88 | 108.29 | p-S6 | 416.40 | |
| Torkinib | HCC1954 | 7.5 | nM | 6 | hr | 176.66 | 32.26 | p-4EBP1 | 41.13 | |
| Torkinib | AU565 | 7.5 | nM | 24 | hr | 440.89 | 99.20 | p-4EBP1 | 147.59 | |
| Torkinib | HCC1954 | 7.5 | nM | 24 | hr | 252.28 | 107.51 | p-4EBP1 | 112.23 | |
| Torkinib | MCF 10A | 7.5 | nM | 6 | hr | 448.64 | 163.43 | p-4EBP1 | 292.01 | |
| Torkinib | AU565 | 7.5 | nM | 6 | hr | 270.94 | 52.71 | p-Akt | 17.37 | |
| Torkinib | HCC1954 | 7.5 | nM | 6 | hr | 166.69 | 28.86 | p-Akt | 16.56 | |
| Torkinib | AU565 | 7.5 | nM | 24 | hr | 463.58 | 90.29 | p-Akt | 56.28 | |
| Torkinib | MCF 10A | 7.5 | nM | 24 | hr | 366.02 | 147.83 | p-Akt | 35.28 | |
| Torkinib | T47D | 7.5 | nM | 24 | hr | 135.75 | 78.36 | p-4EBP1 | 306.59 | |
| Torkinib | AU565 | 7.5 | nM | 6 | hr | 237.10 | 47.79 | p-4EBP1 | 50.80 | |
| Torkinib | AU565 | 7.5 | nM | 24 | hr | 465.15 | 97.95 | p-S6 | 212.59 | |
| Torkinib | HCC1954 | 7.5 | nM | 6 | hr | 176.81 | 34.82 | p-S6 | 63.14 | |
| Torkinib | HCC1954 | 7.5 | nM | 24 | hr | 251.11 | 94.12 | p-Akt | 46.29 | |
| Torkinib | AU565 | 7.5 | nM | 6 | hr | 240.99 | 44.76 | p-Akt | 15.24 | |
| Torkinib | T47D | 7.5 | nM | 24 | hr | 139.90 | 103.43 | p-S6 | 294.61 | |