Breast cell line dose response to target inhibition measured by high throughput microscopy - Dataset (ID:20136)
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| Small Molecule | Cell Line | Drug Concentration | Conc Units | Timepoint | Timepoint Units | Measured pERK (Alexa 488) | Measured p-Rb (Alexa 568) | Alexa Fluor 647 | Measured p-Akt/p-4EBP1/p-S6 (Alexa 647) | Image |
|---|---|---|---|---|---|---|---|---|---|---|
| Torkinib | HCC1954 | 0 (control) | 6 | hr | 198.88 | 47.14 | p-S6 | 108.01 | | |
| Dactolisib | HCC1954 | 0 (control) | 6 | hr | 182.67 | 48.86 | p-S6 | 100.01 | | |
| MK2206 | AU565 | 0 (control) | 6 | hr | 277.65 | 78.69 | p-S6 | 159.10 | | |
| Gefitinib | HCC1954 | 0 (control) | 24 | hr | 306.31 | 118.13 | p-S6 | 303.02 | | |
| MK2206 | HCC1954 | 0 (control) | 6 | hr | 248.38 | 75.69 | p-S6 | 177.47 | | |
| Triciribine | HCC1954 | 0 (control) | 24 | hr | 333.42 | 105.27 | p-S6 | 310.92 | | |
| Torkinib | AU565 | 0 (control) | 6 | hr | 242.92 | 59.35 | p-S6 | 146.55 | | |
| GSK1059615 | AU565 | 0 (control) | 24 | hr | 451.46 | 118.58 | p-S6 | 522.55 | | |
| Triciribine | AU565 | 0 (control) | 24 | hr | 513.50 | 123.82 | p-S6 | 483.08 | | |
| Gefitinib | HCC1954 | 0 (control) | 6 | hr | 203.63 | 52.10 | p-S6 | 78.68 | | |
| GSK1059615 | HCC1954 | 0 (control) | 6 | hr | 398.51 | 94.64 | p-S6 | 384.85 | | |
| GSK1059615 | HCC1954 | 0 (control) | 24 | hr | 360.97 | 111.76 | p-S6 | 338.33 | | |
| MK2206 | HCC1954 | 0 (control) | 24 | hr | 305.43 | 118.14 | p-S6 | 334.28 | | |
| Triciribine | HCC1954 | 0 (control) | 6 | hr | 257.62 | 89.88 | p-S6 | 373.72 | | |
| Gefitinib | AU565 | 0 (control) | 6 | hr | 305.86 | 66.00 | p-S6 | 165.72 | | |
| Gefitinib | AU565 | 0 (control) | 24 | hr | 612.84 | 138.04 | p-S6 | 527.40 | | |
| Torkinib | AU565 | 0 (control) | 24 | hr | 557.64 | 128.55 | p-S6 | 521.30 | | |
| GSK1059615 | AU565 | 0 (control) | 6 | hr | 265.42 | 70.65 | p-S6 | 168.80 | | |
| MK2206 | AU565 | 0 (control) | 24 | hr | 458.85 | 128.23 | p-S6 | 525.22 | | |
| Triciribine | AU565 | 0 (control) | 6 | hr | 344.99 | 87.13 | p-S6 | 242.25 | | |
| Dactolisib | AU565 | 0 (control) | 6 | hr | 246.18 | 58.17 | p-S6 | 130.86 | | |
| Dactolisib | AU565 | 0 (control) | 24 | hr | 529.58 | 125.56 | p-S6 | 517.92 | | |
| Torkinib | HCC1954 | 0 (control) | 24 | hr | 308.22 | 114.54 | p-S6 | 428.36 | | |
| Gefitinib | MCF 10A | 0 (control) | 6 | hr | 472.26 | 160.00 | p-S6 | 457.50 | | |
| Dactolisib | HCC1954 | 0 (control) | 24 | hr | 328.01 | 114.08 | p-S6 | 351.21 | |