Metrics other than potency reveal systematic variation in responses to cancer drugs - Dataset (ID:20120)
Download: Excel (XLSX), Comma-separated (CSV)
| Small Molecule | Cell Line | log10[max. dose (M)] | R^2 (goodness of fit) | log10[EC50 (M)] | log10[IC50 (M)] | log10[GI50 (M)] | HillSlope | E_inf | E_max | AUC |
|---|---|---|---|---|---|---|---|---|---|---|
| GSK461364 | UACC-893 | -4.4776 | 0.7393 | -8.2951 | -8.0674 | -8.3748 | 3.9960 | 0.4309 | 0.4309 | 5.6830 |
| GSK923295 | BT-483 | -4.4776 | 0.7399 | -6.8686 | -4.4776 | -7.1077 | 0.3992 | 0.6796 | 0.7119 | 7.8583 |
| GSK1070916 | UACC-812 | -4.4776 | 0.7401 | -5.0020 | -4.4776 | -5.0814 | 3.9990 | 0.6105 | 0.6136 | 9.2304 |
| NU6102 | MDA-MB-157 | -4.1759 | 0.7402 | -4.2713 | -4.2713 | -4.2761 | 3.9920 | 0.0000 | 0.2938 | 8.3532 |
| Gefitinib | MDA-MB-134-VI | -4.4776 | 0.7412 | -4.3340 | -4.4776 | -4.6396 | 2.5020 | 0.0000 | 0.6958 | 8.9418 |
| Everolimus | SK-BR-3 | -4.1759 | 0.7413 | -5.3239 | -5.3235 | -6.7240 | 0.3266 | 0.0001 | 0.2967 | 6.5953 |
| Taxol | BT-483 | -4.4776 | 0.7415 | -5.8896 | -4.4776 | -6.9608 | 0.3466 | 0.5285 | 0.6439 | 7.7105 |
| XRP44X | MDA-MB-436 | -3.8761 | 0.7416 | -5.9051 | -3.8761 | -5.8819 | 3.9970 | 0.5494 | 0.5494 | 7.7086 |
| Baicalein | HCC1806 | -3.7773 | 0.7422 | -4.6096 | -4.1230 | -4.4280 | 1.6310 | 0.4196 | 0.4440 | 8.0379 |
| CGC-11047 | MDA-MB-175-VII | -2.3010 | 0.7425 | -2.5466 | -2.5467 | -3.4620 | 1.0200 | 0.0000 | 0.3596 | 7.8026 |
| Ibandronate | BT-474 | -2.8239 | 0.7426 | -4.0049 | -2.8239 | -4.0309 | 2.1170 | 0.5619 | 0.5633 | 7.9947 |
| Temsirolimus | LY2 | -3.8761 | 0.7428 | -5.4146 | -5.4148 | NaN | 0.3363 | 0.0000 | 0.2349 | 5.8972 |
| Lestaurtinib | MDA-MB-175-VII | -4.4776 | 0.7465 | -6.0516 | -5.1586 | -6.3133 | 2.4785 | 0.4079 | 0.4115 | 7.0386 |
| CGC-11047 | MDA-MB-157 | -2.3010 | 0.7465 | -3.1877 | -3.1878 | -3.5106 | 0.4622 | 0.0000 | 0.2802 | 6.6765 |
| Trametinib | HCC1143 | -4.7773 | 0.7467 | -8.0903 | -4.7773 | -4.7773 | 2.0720 | 0.7862 | 0.7862 | 8.0205 |
| Nutlin 3a | BT-483 | -4.1759 | 0.7468 | -3.9453 | -4.1759 | -5.4459 | 0.5585 | 0.0000 | 0.5736 | 7.8917 |
| Docetaxel | HCC1419 | -5.0000 | 0.7471 | -7.7670 | -5.0000 | -7.8886 | 1.6530 | 0.7057 | 0.7057 | 8.4471 |
| Gefitinib | HCC38 | -4.4776 | 0.7476 | -4.9435 | -4.4776 | -4.9022 | 3.9980 | 0.5579 | 0.5639 | 8.6262 |
| Triciribine | HCC1954 | -4.4776 | 0.7479 | -5.0011 | -4.4776 | -4.9238 | 0.4139 | 0.2296 | 0.5341 | 7.4613 |
| (Z)-4-Hydroxytamoxifen | MDA-MB-134-VI | -3.7773 | 0.7481 | -3.0115 | -3.7773 | NaN | 0.2750 | 0.0000 | 0.6189 | 7.7008 |
| Temsirolimus | HCC3153 | -3.8761 | 0.7482 | -4.8529 | -4.8529 | -5.3311 | 0.4125 | 0.0000 | 0.2834 | 6.6379 |
| (Z)-4-Hydroxytamoxifen | MCF7 | -3.7773 | 0.7486 | -4.6808 | -3.9578 | -4.1395 | 0.4719 | 0.2859 | 0.5291 | 7.6945 |
| CPT-11 | HCC2185 | -4.0696 | 0.7490 | -5.0032 | -4.0696 | -5.8406 | 0.8157 | 0.6463 | 0.6985 | 8.4849 |
| Nutlin 3a | HCC2185 | -4.1759 | 0.7492 | -4.2261 | -4.2261 | -4.7421 | 1.5410 | 0.0000 | 0.4567 | 8.2851 |
| Everolimus | HCC1428 | -4.1759 | 0.7496 | -4.9143 | -4.9144 | -5.6969 | 0.5917 | 0.0000 | 0.2677 | 6.8292 |