Metrics other than potency reveal systematic variation in responses to cancer drugs - Dataset (ID:20120)
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| Small Molecule | Cell Line | log10[max. dose (M)] | R^2 (goodness of fit) | log10[EC50 (M)] | log10[IC50 (M)] | log10[GI50 (M)] | HillSlope | E_inf | E_max | AUC |
|---|---|---|---|---|---|---|---|---|---|---|
| Omipalisib | BT-483 | -4.4776 | 0.9810 | -7.7216 | -7.1924 | -8.8962 | 0.5153 | 0.2330 | 0.2490 | 5.0745 |
| Taxol | MDA-MB-361 | -4.4776 | 0.9721 | -7.7206 | -7.0959 | -7.8297 | 1.4295 | 0.4323 | 0.4323 | 6.0960 |
| Taxol | HCC1937 | -4.4776 | 0.8964 | -7.7206 | -4.4776 | -7.8332 | 1.5660 | 0.5548 | 0.5548 | 6.8888 |
| Fascaplysin | HCC1187 | -4.4776 | 0.9758 | -7.7196 | -7.7192 | -7.9829 | 2.0550 | 0.0021 | 0.0021 | 4.1023 |
| Afatinib | BT-474 | -4.1759 | 0.9561 | -7.7189 | -7.6261 | -8.2964 | 0.7528 | 0.0745 | 0.0764 | 3.8218 |
| Geldanamycin | MDA-MB-231 | -4.0000 | 0.9804 | -7.7180 | -7.6512 | -7.7148 | 3.3390 | 0.2135 | 0.2135 | 4.4922 |
| Gemcitabine | HCC3153 | -3.8416 | 0.8777 | -7.7166 | -3.8416 | -7.0757 | 3.3230 | 0.6587 | 0.6587 | 7.0092 |
| GSK923295 | MDA-MB-436 | -4.4776 | 0.7796 | -7.7146 | -6.8133 | -7.6733 | 2.0440 | 0.4928 | 0.4928 | 6.4428 |
| Ispinesib | HCC202 | -4.4776 | 0.9414 | -7.7126 | -7.6062 | -8.1286 | 1.4930 | 0.1532 | 0.1532 | 4.6928 |
| Omipalisib | LY2 | -4.4776 | 0.9684 | -7.7116 | -7.6721 | -7.9504 | 1.3520 | 0.0577 | 0.0577 | 4.3944 |
| Afatinib | SK-BR-3 | -4.1759 | 0.9367 | -7.7099 | -7.6424 | -7.9074 | 1.3890 | 0.0967 | 0.0967 | 3.8403 |
| Everolimus | CAMA-1 | -4.1759 | 0.9264 | -7.7079 | -7.4026 | -8.1267 | 0.6537 | 0.1842 | 0.1882 | 4.5374 |
| Geldanamycin | HCC2185 | -4.0000 | 0.9492 | -7.7050 | -7.5465 | -7.8857 | 2.8510 | 0.3693 | 0.3693 | 5.2148 |
| Torkinib | MDA-MB-157 | -4.3010 | 0.9776 | -7.6960 | -7.6959 | -7.9967 | 0.3909 | 0.0000 | 0.0450 | 3.6514 |
| Geldanamycin | MCF12A | -4.0000 | 0.9897 | -7.6935 | -7.6765 | -7.7504 | 3.2375 | 0.0600 | 0.0600 | 3.6298 |
| Geldanamycin | UACC-812 | -4.0000 | 0.9479 | -7.6900 | -7.4889 | -7.8250 | 3.4085 | 0.3924 | 0.3924 | 5.5975 |
| Vinorelbine | HCC70 | -4.3335 | 0.8579 | -7.6870 | -7.5722 | -7.7966 | 2.8670 | 0.2475 | 0.2475 | 4.9618 |
| Geldanamycin | MDA-MB-175-VII | -4.0000 | 0.9905 | -7.6860 | -7.5417 | -7.8110 | 2.9170 | 0.3107 | 0.3107 | 4.9876 |
| Topotecan | MDA-MB-436 | -3.9626 | 0.8541 | -7.6856 | -7.4176 | -7.6979 | 2.4115 | 0.3168 | 0.3170 | 5.1664 |
| Torkinib | MCF12A | -4.3010 | 0.9504 | -7.6850 | -7.0554 | -7.7564 | 0.3975 | 0.2189 | 0.2527 | 4.9015 |
| Vinorelbine | MDA-MB-436 | -4.3335 | 0.8865 | -7.6845 | -7.4414 | -7.6361 | 2.1830 | 0.3079 | 0.3079 | 5.5398 |
| Docetaxel | 600MPE | -5.0000 | 0.7992 | -7.6820 | -5.0000 | -7.1151 | 2.4180 | 0.7415 | 0.7415 | 8.2414 |
| Taxol | HCC1143 | -4.4776 | 0.9579 | -7.6816 | -7.4738 | -7.8328 | 1.7125 | 0.2784 | 0.2784 | 5.4383 |
| GSK461364 | HCC1187 | -4.4776 | 0.8591 | -7.6736 | -7.5666 | -7.7666 | 3.9990 | 0.3118 | 0.3118 | 5.6299 |
| Ispinesib | AU565 | -4.4776 | 0.9911 | -7.6716 | -7.6654 | -7.7173 | 3.9990 | 0.0278 | 0.0278 | 4.1992 |