Evaluation of the sensitivities of six triple-negative breast cancer (TNBC) cell lines to 23 different PI3K/AKT/mTOR inhibitors or to a MEK inhibitor (trametinib). Dataset 2 of 2: GR metrics. - Dataset - HMS LINCS Database

Evaluation of the sensitivities of six triple-negative breast cancer (TNBC) cell lines to 23 different PI3K/AKT/mTOR inhibitors or to a MEK inhibitor (trametinib). Dataset 2 of 2: GR metrics. - Dataset (ID:20365)

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Cell line	Drug name	Experimental replicate	Timepoint	Curve type (GR values)	Curve type (relative cell counts)	Experiment name	Number of concentrations	Cell doublings (DMSO control)	GR50	GRmax	GR_AOC	GEC50	GRinf	Hill slope (GR values)	R-squared sigmoid fit (GR values)	P-value sigmoid fit (GR values)	R-squared flat fit (GR values)	IC50	Emax	AUC	EC50	Einf	Hill slope (relative cell counts)	R-squared sigmoid fit (relative cell counts)	P-value sigmoid fit (relative cell counts)	R-squared flat fit (relative cell counts)
BT-549	TGX221	3	72	sigmoid	sigmoid	BT549 TGX-221 0 3 72	8	1.768	93790.0	0.805	0.0889	320.0	0.356	0.22	0.707	0.0251	NA	49050766.0	0.834	0.923	320.0	0.461	0.214	0.703	0.0263	NA
BT-549	Torin1	1	72	sigmoid	sigmoid	BT549 Torin1 0 1 72	8	1.794	0.017	0.0603	0.621	0.0151	0.056	0.976	0.998	7.25e-09	NA	0.0333	0.32	0.532	0.0118	0.316	0.966	0.998	9.27e-09	NA
BT-549	Torin1	2	72	sigmoid	sigmoid	BT549 Torin1 0 2 72	8	1.881	0.0165	0.0298	0.618	0.0147	0.0572	1.03	0.993	4.2e-07	NA	0.0262	0.287	0.52	0.0111	0.306	1.1	0.99	9.68e-07	NA
BT-549	Torin1	3	72	sigmoid	sigmoid	BT549 Torin1 0 3 72	8	1.757	0.0123	0.026	0.659	0.0112	0.0466	1.02	0.997	3.77e-08	NA	0.0235	0.309	0.513	0.00878	0.322	1.05	0.997	1.65e-08	NA
BT-549	Torin2	1	72	sigmoid	sigmoid	BT549 Torin2 0 1 72	8	1.771	0.0095	-0.218	0.756	0.0155	-0.193	0.672	0.985	3.06e-06	NA	0.0183	0.19	0.452	0.00874	0.218	0.775	0.988	1.88e-06	NA
BT-549	Torin2	2	72	sigmoid	sigmoid	BT549 Torin2 0 2 72	8	1.824	0.00997	-0.281	0.767	0.0212	-0.282	0.594	0.975	1.47e-05	NA	0.0177	0.155	0.438	0.00929	0.188	0.734	0.973	2.02e-05	NA
BT-549	Torin2	3	72	sigmoid	sigmoid	BT549 Torin2 0 3 72	8	1.613	0.00797	-0.254	0.794	0.0216	-0.338	0.517	0.98	8.52e-06	NA	0.0236	0.204	0.458	0.0104	0.191	0.585	0.976	1.3e-05	NA
BT-549	Trametinib	1	72	sigmoid	sigmoid	BT549 trametinib 0 1 72	8	1.812	Inf	0.596	0.202	0.131	0.523	0.61	0.959	6.65e-05	NA	28.3	0.664	0.828	3.47	0.254	0.337	0.933	0.000305	NA
BT-549	Trametinib	2	72	sigmoid	sigmoid	BT549 trametinib 0 2 72	8	1.914	Inf	0.602	0.2	0.0685	0.581	0.837	0.995	1.05e-07	NA	Inf	0.654	0.822	0.0601	0.638	0.839	0.995	1.04e-07	NA
BT-549	Trametinib	3	72	sigmoid	sigmoid	BT549 trametinib 0 3 72	8	1.755	Inf	0.553	0.223	0.107	0.505	0.899	0.942	0.000194	NA	Inf	0.642	0.817	0.104	0.595	0.804	0.938	0.000236	NA
BT-549	WYE-125132	1	72	sigmoid	sigmoid	BT549 WYE-132 0 1 72	8	1.787	0.0317	0.11	0.542	0.026	0.0962	1.09	0.996	5.11e-08	NA	0.062	0.349	0.589	0.0213	0.338	1.05	0.997	3.82e-08	NA
BT-549	WYE-125132	2	72	sigmoid	sigmoid	BT549 WYE-132 0 2 72	8	1.780	0.0329	0.0784	0.528	0.0287	0.0811	1.29	0.988	1.59e-06	NA	0.0545	0.333	0.604	0.0236	0.337	1.34	0.986	2.87e-06	NA
BT-549	WYE-125132	3	72	sigmoid	sigmoid	BT549 WYE-132 0 3 72	8	1.662	0.0271	0.0265	0.567	0.0245	0.0525	1.1	0.992	5.72e-07	NA	0.0574	0.33	0.592	0.0203	0.345	1.13	0.991	6.54e-07	NA
BT-549	XL147	1	72	flat	flat	BT549 pilaralisib 0 1 72	8	1.855	Inf	0.941	0.0385	0.0	0.941	0.01	-0.0931	1.0	0.954	Inf	0.946	0.965	0.0	0.946	0.01	-0.0808	1.0	0.958
BT-549	XL147	2	72	flat	flat	BT549 pilaralisib 0 2 72	8	1.952	Inf	0.967	-0.00824	0.0	0.967	0.01	-0.000427	1.0	1.0	Inf	0.968	1.01	0.0	0.968	0.01	-0.000878	1.0	1.0
BT-549	XL147	3	72	flat	flat	BT549 pilaralisib 0 3 72	8	1.772	Inf	0.933	0.0351	0.0	0.933	0.01	-0.0699	1.0	0.962	Inf	0.941	0.969	0.0	0.941	0.01	-0.0712	1.0	0.967
BT-549	ZSTK474	1	72	sigmoid	sigmoid	BT549 ZSTK474 0 1 72	8	1.861	0.58	0.213	0.256	0.583	-0.00205	0.771	0.992	5.43e-07	NA	1.12	0.394	0.788	0.428	0.261	0.767	0.989	1.49e-06	NA
BT-549	ZSTK474	2	72	sigmoid	sigmoid	BT549 ZSTK474 0 2 72	8	1.962	0.628	0.144	0.245	0.841	-0.139	0.84	0.995	1.29e-07	NA	0.958	0.334	0.791	0.595	0.163	0.828	0.992	4.28e-07	NA
BT-549	ZSTK474	3	72	sigmoid	sigmoid	BT549 ZSTK474 0 3 72	8	1.776	0.504	0.139	0.267	0.616	-0.0912	0.836	0.996	7.06e-08	NA	0.994	0.368	0.789	0.489	0.218	0.808	0.995	9.19e-08	NA
HCC38	AS605240	1	72	sigmoid	sigmoid	HCC38 AS-605240 0 1 72	8	1.744	Inf	0.734	0.0803	0.448	0.691	0.881	0.969	2.92e-05	NA	Inf	0.78	0.932	0.405	0.748	0.895	0.967	3.48e-05	NA
HCC38	AS605240	2	72	sigmoid	sigmoid	HCC38 AS-605240 0 2 72	8	2.200	17.4	0.642	0.114	4.07	0.256	0.493	0.936	0.000265	NA	46.2	0.648	0.882	1.68	0.411	0.522	0.929	0.000356	NA
HCC38	AS605240	3	72	flat	flat	HCC38 AS-605240 0 3 72	8	1.343	Inf	0.958	-0.0162	0.0	0.958	0.01	-0.233	1.0	1.01	Inf	0.972	1.01	0.0	0.972	0.01	-0.235	1.0	1.01
HCC38	AZD-6482	1	72	sigmoid	sigmoid	HCC38 AZD6482 0 1 72	8	1.732	Inf	0.862	0.0239	1.4	0.804	1.03	0.909	0.000761	NA	Inf	0.883	0.98	1.34	0.837	1.03	0.904	0.000873	NA
HCC38	AZD-6482	2	72	sigmoid	sigmoid	HCC38 AZD6482 0 2 72	8	2.132	Inf	0.898	0.0351	4.71	0.773	0.497	0.824	0.0055	NA	Inf	0.894	0.963	4.7	0.765	0.492	0.82	0.00588	NA
HCC38	AZD-6482	3	72	sigmoid	sigmoid	HCC38 AZD6482 0 3 72	8	1.420	Inf	0.821	0.0615	0.324	0.826	5.0	0.849	0.00342	NA	Inf	0.875	0.957	0.323	0.879	5.0	0.846	0.00367	NA

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HMS LINCS Project

Evaluation of the sensitivities of six triple-negative breast cancer (TNBC) cell lines to 23 different PI3K/AKT/mTOR inhibitors or to a MEK inhibitor (trametinib). Dataset 2 of 2: GR metrics. - Dataset (ID:20365)