Evaluation of the sensitivities of six triple-negative breast cancer (TNBC) cell lines to 23 different PI3K/AKT/mTOR inhibitors or to a MEK inhibitor (trametinib). Dataset 2 of 2: GR metrics. - Dataset (ID:20365)

 Full screen view
Filter results: >>>>
Cell line Drug name Experimental replicate Timepoint Curve type (GR values) Curve type (relative cell counts) Experiment name Number of concentrations Cell doublings (DMSO control) GR50 GRmax GR_AOC GEC50 GRinf Hill slope (GR values) R-squared sigmoid fit (GR values) P-value sigmoid fit (GR values) R-squared flat fit (GR values) IC50 Emax AUC EC50 Einf Hill slope (relative cell counts) R-squared sigmoid fit (relative cell counts) P-value sigmoid fit (relative cell counts) R-squared flat fit (relative cell counts)
Hs 578T BX-912 1
sigmoid
sigmoid
Hs578T BX-912 1
 8 2.001
0.771
-0.202
0.191
1.16
-0.444
1.57
0.997
2.97e-08
NA
0.901
0.159
0.851
0.822
0.0702
1.64
0.994
1.9e-07
NA
Hs 578T BX-912 2
sigmoid
sigmoid
Hs578T BX-912 2
 8 2.540
1.07
-0.019
0.174
1.79
-0.489
1.33
0.998
6.37e-09
NA
1.01
0.164
0.828
1.01
0.0
1.4
0.996
7.64e-08
NA
Hs 578T BX-912 3
sigmoid
sigmoid
Hs578T BX-912 3
 8 2.805
1.04
0.0121
0.125
1.09
-0.0661
2.36
0.992
4.22e-07
NA
0.936
0.148
0.883
0.841
0.116
2.45
0.982
5.7e-06
NA
Hs 578T Alpelisib 1
sigmoid
sigmoid
Hs578T alpelisib 1
 8 2.097
2.3
0.449
0.205
42.0
-1.0
0.378
0.954
9.56e-05
NA
3.9
0.508
0.803
3.9
0.0
0.401
0.94
0.000216
NA
Hs 578T Alpelisib 2
flat
flat
Hs578T alpelisib 2
 8 2.513
Inf
0.668
0.131
0.0
0.668
0.01
0.599
0.0647
0.856
Inf
0.634
0.847
0.0
0.634
0.01
0.541
0.0969
0.833
Hs 578T Alpelisib 3
sigmoid
sigmoid
Hs578T alpelisib 3
 8 2.856
Inf
0.712
0.0759
0.872
0.616
0.828
0.963
5.21e-05
NA
Inf
0.641
0.901
0.65
0.553
0.853
0.955
8.85e-05
NA
Hs 578T CAL-101 1
sigmoid
sigmoid
Hs578T idelalisib 1
 8 2.050
27.9
0.72
0.0764
4.56
0.356
0.688
0.945
0.000168
NA
18.7
0.734
0.925
18.7
0.0
0.568
0.941
0.000203
NA
Hs 578T CAL-101 2
sigmoid
sigmoid
Hs578T idelalisib 2
 8 2.534
57.5
0.801
0.0636
320.0
-0.507
0.408
0.979
9.58e-06
NA
Inf
0.766
0.923
4.27
0.505
0.495
0.975
1.65e-05
NA
Hs 578T CAL-101 3
sigmoid
sigmoid
Hs578T idelalisib 3
 8 2.874
Inf
0.854
0.0202
1.12
0.835
1.91
0.991
6.68e-07
NA
Inf
0.805
0.972
1.07
0.781
1.92
0.99
9.77e-07
NA
Hs 578T Everolimus 1
sigmoid
sigmoid
Hs578T everolimus 1
 8 2.030
1707115.0
0.626
0.318
0.00576
0.429
0.1
0.895
0.00116
NA
2.51e+21
0.657
0.704
0.00121
0.502
0.1
0.893
0.00124
NA
Hs 578T Everolimus 2
sigmoid
sigmoid
Hs578T everolimus 2
 8 2.550
3210000000.0
0.626
0.335
0.000205
0.476
0.1
0.791
0.00913
NA
18938.0
0.59
0.627
0.000153
0.422
0.1
0.745
0.0166
NA
Hs 578T Everolimus 3
flat
flat
Hs578T everolimus 3
 8 2.848
Inf
0.664
0.299
0.0
0.664
0.01
0.475
0.144
0.702
Inf
0.592
0.631
0.0
0.592
0.01
0.486
0.136
0.632
Hs 578T Pictilisib 1
sigmoid
sigmoid
Hs578T pictilisib 1
 8 2.048
0.482
0.341
0.267
0.162
0.295
0.819
0.998
8.97e-09
NA
0.981
0.441
0.759
0.12
0.416
0.847
0.998
6.97e-09
NA
Hs 578T Pictilisib 2
sigmoid
sigmoid
Hs578T pictilisib 2
 8 2.512
1.93
0.45
0.194
0.4
0.333
0.696
0.98
8e-06
NA
1.58
0.446
0.787
0.231
0.381
0.746
0.974
1.74e-05
NA
Hs 578T Pictilisib 3
sigmoid
sigmoid
Hs578T pictilisib 3
 8 2.911
2.33
0.471
0.168
0.364
0.403
0.883
0.996
5.24e-08
NA
0.97
0.409
0.794
0.228
0.374
0.952
0.996
5.98e-08
NA
Hs 578T GDC-0980 1
sigmoid
sigmoid
Hs578T apitolisib 1
 8 1.984
0.119
-0.0587
0.419
0.141
-0.0865
0.957
0.997
3.35e-08
NA
0.161
0.224
0.662
0.0914
0.223
1.04
0.997
2.87e-08
NA
Hs 578T GDC-0980 2
sigmoid
sigmoid
Hs578T apitolisib 2
 8 2.520
0.176
-0.0558
0.391
0.275
-0.201
0.758
0.997
3.91e-08
NA
0.159
0.151
0.627
0.121
0.1
0.818
0.998
1.45e-08
NA
Hs 578T GDC-0980 3
sigmoid
sigmoid
Hs578T apitolisib 3
 8 2.831
0.243
0.145
0.315
0.19
0.112
1.02
0.998
4.02e-09
NA
0.179
0.206
0.665
0.114
0.196
1.09
0.999
9.76e-10
NA
Hs 578T Omipalisib 1
sigmoid
sigmoid
Hs578T omipalisib 1
 8 2.079
0.00552
-0.546
0.842
0.17
-1.0
0.321
0.98
8.1e-06
NA
0.0079
0.0459
0.351
0.0079
0.0
0.369
0.984
4.12e-06
NA
Hs 578T Omipalisib 2
sigmoid
sigmoid
Hs578T omipalisib 2
 8 2.507
0.0155
-0.52
0.766
0.239
-1.0
0.402
0.993
3.45e-07
NA
0.0114
0.028
0.355
0.0114
0.0
0.468
0.981
6.9e-06
NA
Hs 578T Omipalisib 3
sigmoid
sigmoid
Hs578T omipalisib 3
 8 2.869
0.0255
-0.107
0.615
0.0533
-0.22
0.494
0.99
8.79e-07
NA
0.0145
0.0989
0.392
0.0102
0.0968
0.62
0.993
3.4e-07
NA
Hs 578T KIN001-244 1
sigmoid
sigmoid
Hs578T KIN001-244 1
 8 2.041
24.7
0.739
0.0391
4.05
0.414
0.972
0.968
3.4e-05
NA
Inf
0.752
0.962
3.15
0.51
0.99
0.964
4.65e-05
NA
Hs 578T KIN001-244 2
sigmoid
sigmoid
Hs578T KIN001-244 2
 8 2.505
Inf
0.819
0.0357
4.8
0.531
1.14
0.891
0.0013
NA
44.3
0.788
0.957
4.79
0.457
1.1
0.878
0.0018
NA
Hs 578T KIN001-244 3
sigmoid
sigmoid
Hs578T KIN001-244 3
 8 2.888
Inf
0.866
0.00909
5.05
0.617
1.35
0.858
0.00289
NA
50.0
0.818
0.988
5.2
0.474
1.31
0.842
0.00391
NA
Hs 578T MK2206 1
sigmoid
sigmoid
Hs578T MK-2206 1
 8 2.039
Inf
0.608
0.165
0.087
0.665
2.09
0.9
0.00101
NA
Inf
0.641
0.845
0.0803
0.689
1.9
0.908
0.000775
NA