Evaluation of the sensitivities of six triple-negative breast cancer (TNBC) cell lines to 23 different PI3K/AKT/mTOR inhibitors or to a MEK inhibitor (trametinib). Dataset 1 of 2: GR values. - Dataset (ID:20364)
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| Cell line | Drug name | Experimental replicate | Timepoint | Drug concentration | Live cell count | Average live cell count, DMSO control | Average live cell count (time = 0) | Log10(drug concentration) | GR value | Relative cell count (treatment versus DMSO) | Cell doublings (DMSO control) | Experiment name |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| HCC70 | XL147 | 2 | 72 | 0.1 | 2483.8 | 2497.8 | 722.8 | -1.0 | 0.994 | 0.994 | 1.789 | HCC70 XL147 0 2 72 |
| HCC70 | XL147 | 2 | 72 | 0.32 | 2445.8 | 2497.8 | 722.8 | -0.495 | 0.977 | 0.979 | 1.789 | HCC70 XL147 0 2 72 |
| HCC70 | XL147 | 2 | 72 | 1.0 | 2506.5 | 2497.8 | 722.8 | 0.0 | 1.000 | 1.000 | 1.789 | HCC70 XL147 0 2 72 |
| HCC70 | XL147 | 2 | 72 | 3.2 | 2422.5 | 2497.8 | 722.8 | 0.505 | 0.966 | 0.970 | 1.789 | HCC70 XL147 0 2 72 |
| HCC70 | ZSTK474 | 2 | 72 | 0.001 | 2517.3 | 2409.0 | 722.8 | -3.0 | 1.050 | 1.040 | 1.737 | HCC70 ZSTK474 0 2 72 |
| HCC70 | ZSTK474 | 2 | 72 | 0.0032 | 2344.0 | 2409.0 | 722.8 | -2.49 | 0.969 | 0.973 | 1.737 | HCC70 ZSTK474 0 2 72 |
| HCC70 | ZSTK474 | 2 | 72 | 0.01 | 2336.3 | 2409.0 | 722.8 | -2.0 | 0.965 | 0.970 | 1.737 | HCC70 ZSTK474 0 2 72 |
| HCC70 | ZSTK474 | 2 | 72 | 0.032 | 2430.5 | 2409.0 | 722.8 | -1.49 | 1.010 | 1.010 | 1.737 | HCC70 ZSTK474 0 2 72 |
| HCC70 | ZSTK474 | 2 | 72 | 0.1 | 1917.3 | 2409.0 | 722.8 | -1.0 | 0.754 | 0.796 | 1.737 | HCC70 ZSTK474 0 2 72 |
| HCC70 | ZSTK474 | 2 | 72 | 0.32 | 1297.0 | 2409.0 | 722.8 | -0.495 | 0.400 | 0.538 | 1.737 | HCC70 ZSTK474 0 2 72 |
| HCC70 | ZSTK474 | 2 | 72 | 1.0 | 892.3 | 2409.0 | 722.8 | 0.0 | 0.129 | 0.370 | 1.737 | HCC70 ZSTK474 0 2 72 |
| HCC70 | ZSTK474 | 2 | 72 | 3.2 | 673.8 | 2409.0 | 722.8 | 0.505 | -0.040 | 0.280 | 1.737 | HCC70 ZSTK474 0 2 72 |
| HCC70 | AS605240 | 3 | 72 | 0.001 | 2799.3 | 2821.5 | 517.3 | -3.0 | 0.994 | 0.992 | 2.447 | HCC70 AS605240 0 3 72 |
| HCC70 | AS605240 | 3 | 72 | 0.0032 | 2836.0 | 2821.5 | 517.3 | -2.49 | 1.000 | 1.010 | 2.447 | HCC70 AS605240 0 3 72 |
| HCC70 | AS605240 | 3 | 72 | 0.01 | 2809.8 | 2821.5 | 517.3 | -2.0 | 0.997 | 0.996 | 2.447 | HCC70 AS605240 0 3 72 |
| HCC70 | AS605240 | 3 | 72 | 0.032 | 2913.0 | 2821.5 | 517.3 | -1.49 | 1.030 | 1.030 | 2.447 | HCC70 AS605240 0 3 72 |
| HCC70 | AS605240 | 3 | 72 | 0.1 | 2523.0 | 2821.5 | 517.3 | -1.0 | 0.911 | 0.894 | 2.447 | HCC70 AS605240 0 3 72 |
| HCC70 | AS605240 | 3 | 72 | 0.32 | 2196.8 | 2821.5 | 517.3 | -0.495 | 0.806 | 0.779 | 2.447 | HCC70 AS605240 0 3 72 |
| HCC70 | AS605240 | 3 | 72 | 1.0 | 1850.8 | 2821.5 | 517.3 | 0.0 | 0.683 | 0.656 | 2.447 | HCC70 AS605240 0 3 72 |
| HCC70 | AS605240 | 3 | 72 | 3.2 | 1585.8 | 2821.5 | 517.3 | 0.505 | 0.580 | 0.562 | 2.447 | HCC70 AS605240 0 3 72 |
| HCC70 | AZD-6482 | 3 | 72 | 0.001 | 2842.0 | 2991.0 | 517.3 | -3.0 | 0.960 | 0.950 | 2.532 | HCC70 AZD6482 0 3 72 |
| HCC70 | AZD-6482 | 3 | 72 | 0.0032 | 2677.0 | 2991.0 | 517.3 | -2.49 | 0.914 | 0.895 | 2.532 | HCC70 AZD6482 0 3 72 |
| HCC70 | AZD-6482 | 3 | 72 | 0.01 | 2686.0 | 2991.0 | 517.3 | -2.0 | 0.917 | 0.898 | 2.532 | HCC70 AZD6482 0 3 72 |
| HCC70 | AZD-6482 | 3 | 72 | 0.032 | 2461.0 | 2991.0 | 517.3 | -1.49 | 0.852 | 0.823 | 2.532 | HCC70 AZD6482 0 3 72 |
| HCC70 | AZD-6482 | 3 | 72 | 0.1 | 1977.0 | 2991.0 | 517.3 | -1.0 | 0.698 | 0.661 | 2.532 | HCC70 AZD6482 0 3 72 |