Evaluation of the sensitivities of six triple-negative breast cancer (TNBC) cell lines to 23 different PI3K/AKT/mTOR inhibitors or to a MEK inhibitor (trametinib). Dataset 1 of 2: GR values. - Dataset (ID:20364)
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| Cell line | Drug name | Experimental replicate | Timepoint | Drug concentration | Live cell count | Average live cell count, DMSO control | Average live cell count (time = 0) | Log10(drug concentration) | GR value | Relative cell count (treatment versus DMSO) | Cell doublings (DMSO control) | Experiment name |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| HCC38 | Buparlisib | 3 | 72 | 3.2 | 599.0 | 3184.0 | 1180.5 | 0.505 | -0.377 | 0.188 | 1.431 | HCC38 BKM120 0 3 72 |
| HCC38 | BX-912 | 3 | 72 | 0.001 | 3071.5 | 3233.3 | 1180.5 | -3.0 | 0.931 | 0.950 | 1.454 | HCC38 BX912 0 3 72 |
| HCC38 | BX-912 | 3 | 72 | 0.0032 | 3134.3 | 3233.3 | 1180.5 | -2.49 | 0.958 | 0.969 | 1.454 | HCC38 BX912 0 3 72 |
| HCC38 | BX-912 | 3 | 72 | 0.01 | 3051.8 | 3233.3 | 1180.5 | -2.0 | 0.922 | 0.944 | 1.454 | HCC38 BX912 0 3 72 |
| HCC38 | BX-912 | 3 | 72 | 0.032 | 3154.8 | 3233.3 | 1180.5 | -1.49 | 0.966 | 0.976 | 1.454 | HCC38 BX912 0 3 72 |
| HCC38 | BX-912 | 3 | 72 | 0.1 | 3076.8 | 3233.3 | 1180.5 | -1.0 | 0.933 | 0.952 | 1.454 | HCC38 BX912 0 3 72 |
| HCC38 | BX-912 | 3 | 72 | 0.32 | 2858.3 | 3233.3 | 1180.5 | -0.495 | 0.837 | 0.884 | 1.454 | HCC38 BX912 0 3 72 |
| HCC38 | BX-912 | 3 | 72 | 1.0 | 524.3 | 3233.3 | 1180.5 | 0.0 | -0.428 | 0.162 | 1.454 | HCC38 BX912 0 3 72 |
| HCC38 | BX-912 | 3 | 72 | 3.2 | 555.8 | 3233.3 | 1180.5 | 0.505 | -0.404 | 0.172 | 1.454 | HCC38 BX912 0 3 72 |
| HCC38 | Alpelisib | 3 | 72 | 0.001 | 2614.8 | 3111.0 | 1180.5 | -3.0 | 0.766 | 0.840 | 1.398 | HCC38 BYL719 0 3 72 |
| HCC38 | Alpelisib | 3 | 72 | 0.0032 | 3042.8 | 3111.0 | 1180.5 | -2.49 | 0.969 | 0.978 | 1.398 | HCC38 BYL719 0 3 72 |
| HCC38 | Alpelisib | 3 | 72 | 0.01 | 2965.5 | 3111.0 | 1180.5 | -2.0 | 0.933 | 0.953 | 1.398 | HCC38 BYL719 0 3 72 |
| HCC38 | Alpelisib | 3 | 72 | 0.032 | 2966.3 | 3111.0 | 1180.5 | -1.49 | 0.933 | 0.953 | 1.398 | HCC38 BYL719 0 3 72 |
| HCC38 | Alpelisib | 3 | 72 | 0.1 | 3063.8 | 3111.0 | 1180.5 | -1.0 | 0.978 | 0.985 | 1.398 | HCC38 BYL719 0 3 72 |
| HCC38 | Alpelisib | 3 | 72 | 0.32 | 2952.3 | 3111.0 | 1180.5 | -0.495 | 0.926 | 0.949 | 1.398 | HCC38 BYL719 0 3 72 |
| HCC38 | Alpelisib | 3 | 72 | 1.0 | 2702.5 | 3111.0 | 1180.5 | 0.0 | 0.808 | 0.869 | 1.398 | HCC38 BYL719 0 3 72 |
| HCC38 | Alpelisib | 3 | 72 | 3.2 | 2580.5 | 3111.0 | 1180.5 | 0.505 | 0.750 | 0.829 | 1.398 | HCC38 BYL719 0 3 72 |
| HCC38 | CAL-101 | 3 | 72 | 0.001 | 3140.0 | 3209.8 | 1180.5 | -3.0 | 0.970 | 0.978 | 1.443 | HCC38 CAL101 0 3 72 |
| HCC38 | CAL-101 | 3 | 72 | 0.0032 | 3108.3 | 3209.8 | 1180.5 | -2.49 | 0.956 | 0.968 | 1.443 | HCC38 CAL101 0 3 72 |
| HCC38 | CAL-101 | 3 | 72 | 0.01 | 3029.3 | 3209.8 | 1180.5 | -2.0 | 0.921 | 0.944 | 1.443 | HCC38 CAL101 0 3 72 |
| HCC38 | CAL-101 | 3 | 72 | 0.032 | 3105.3 | 3209.8 | 1180.5 | -1.49 | 0.955 | 0.967 | 1.443 | HCC38 CAL101 0 3 72 |
| HCC38 | CAL-101 | 3 | 72 | 0.1 | 2981.5 | 3209.8 | 1180.5 | -1.0 | 0.900 | 0.929 | 1.443 | HCC38 CAL101 0 3 72 |
| HCC38 | CAL-101 | 3 | 72 | 0.32 | 3046.3 | 3209.8 | 1180.5 | -0.495 | 0.929 | 0.949 | 1.443 | HCC38 CAL101 0 3 72 |
| HCC38 | CAL-101 | 3 | 72 | 1.0 | 2870.5 | 3209.8 | 1180.5 | 0.0 | 0.851 | 0.894 | 1.443 | HCC38 CAL101 0 3 72 |
| HCC38 | CAL-101 | 3 | 72 | 3.2 | 2937.0 | 3209.8 | 1180.5 | 0.505 | 0.881 | 0.915 | 1.443 | HCC38 CAL101 0 3 72 |