Evaluation of the sensitivities of six triple-negative breast cancer (TNBC) cell lines to 23 different PI3K/AKT/mTOR inhibitors or to a MEK inhibitor (trametinib). Dataset 1 of 2: GR values. - Dataset (ID:20364)

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Cell line Drug name Experimental replicate Timepoint Drug concentration Live cell count Average live cell count, DMSO control Average live cell count (time = 0) Log10(drug concentration) GR value Relative cell count (treatment versus DMSO) Cell doublings (DMSO control) Experiment name
HCC38 AS605240 2 72
1.0
 2465.5 3173.5 690.5
0.0
 0.783 0.777 2.200
HCC38 AS605240 0 2 72
HCC38 AS605240 2 72
3.2
 2056.3 3173.5 690.5
0.505
 0.642 0.648 2.200
HCC38 AS605240 0 2 72
HCC38 AZD-6482 2 72
0.001
 3000.0 3027.0 690.5
-3.0
 0.992 0.991 2.132
HCC38 AZD6482 0 2 72
HCC38 AZD-6482 2 72
0.0032
 2939.3 3027.0 690.5
-2.49
 0.973 0.971 2.132
HCC38 AZD6482 0 2 72
HCC38 AZD-6482 2 72
0.01
 2990.5 3027.0 690.5
-2.0
 0.989 0.988 2.132
HCC38 AZD6482 0 2 72
HCC38 AZD-6482 2 72
0.032
 3000.0 3027.0 690.5
-1.49
 0.992 0.991 2.132
HCC38 AZD6482 0 2 72
HCC38 AZD-6482 2 72
0.1
 3010.8 3027.0 690.5
-1.0
 0.995 0.995 2.132
HCC38 AZD6482 0 2 72
HCC38 AZD-6482 2 72
0.32
 2804.0 3027.0 690.5
-0.495
 0.929 0.926 2.132
HCC38 AZD6482 0 2 72
HCC38 AZD-6482 2 72
1.0
 2812.3 3027.0 690.5
0.0
 0.932 0.929 2.132
HCC38 AZD6482 0 2 72
HCC38 AZD-6482 2 72
3.2
 2707.3 3027.0 690.5
0.505
 0.898 0.894 2.132
HCC38 AZD6482 0 2 72
HCC38 AZD8055 2 72
0.001
 2942.8 3018.8 690.5
-3.0
 0.976 0.975 2.128
HCC38 AZD8055 0 2 72
HCC38 AZD8055 2 72
0.0032
 2615.3 3018.8 690.5
-2.49
 0.870 0.866 2.128
HCC38 AZD8055 0 2 72
HCC38 AZD8055 2 72
0.01
 2511.5 3018.8 690.5
-2.0
 0.834 0.832 2.128
HCC38 AZD8055 0 2 72
HCC38 AZD8055 2 72
0.032
 2028.8 3018.8 690.5
-1.49
 0.659 0.672 2.128
HCC38 AZD8055 0 2 72
HCC38 AZD8055 2 72
0.1
 1413.3 3018.8 690.5
-1.0
 0.400 0.468 2.128
HCC38 AZD8055 0 2 72
HCC38 AZD8055 2 72
0.32
 1064.5 3018.8 690.5
-0.495
 0.226 0.353 2.128
HCC38 AZD8055 0 2 72
HCC38 AZD8055 2 72
1.0
 968.3 3018.8 690.5
0.0
 0.172 0.321 2.128
HCC38 AZD8055 0 2 72
HCC38 AZD8055 2 72
3.2
 947.0 3018.8 690.5
0.505
 0.160 0.314 2.128
HCC38 AZD8055 0 2 72
HCC38 Dactolisib 2 72
0.001
 2724.5 3001.5 690.5
-3.0
 0.911 0.908 2.120
HCC38 BEZ235 0 2 72
HCC38 Dactolisib 2 72
0.0032
 2294.8 3001.5 690.5
-2.49
 0.762 0.765 2.120
HCC38 BEZ235 0 2 72
HCC38 Dactolisib 2 72
0.01
 1604.0 3001.5 690.5
-2.0
 0.488 0.534 2.120
HCC38 BEZ235 0 2 72
HCC38 Dactolisib 2 72
0.032
 1163.5 3001.5 690.5
-1.49
 0.279 0.388 2.120
HCC38 BEZ235 0 2 72
HCC38 Dactolisib 2 72
0.1
 1009.5 3001.5 690.5
-1.0
 0.196 0.336 2.120
HCC38 BEZ235 0 2 72
HCC38 Dactolisib 2 72
0.32
 916.0 3001.5 690.5
-0.495
 0.143 0.305 2.120
HCC38 BEZ235 0 2 72
HCC38 Dactolisib 2 72
1.0
 726.5 3001.5 690.5
0.0
 0.024 0.242 2.120
HCC38 BEZ235 0 2 72