Evaluation of the sensitivities of six triple-negative breast cancer (TNBC) cell lines to 23 different PI3K/AKT/mTOR inhibitors or to a MEK inhibitor (trametinib). Dataset 1 of 2: GR values. - Dataset (ID:20364)

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Cell line Drug name Experimental replicate Timepoint Drug concentration Live cell count Average live cell count, DMSO control Average live cell count (time = 0) Log10(drug concentration) GR value Relative cell count (treatment versus DMSO) Cell doublings (DMSO control) Experiment name
Hs 578T Pictilisib 2 72
1.0
 1994.5 3563.3 624.7
0.0
 0.587 0.560 2.512
Hs578T GDC0941 2
Hs 578T Pictilisib 2 72
3.2
 1587.5 3563.3 624.7
0.505
 0.450 0.446 2.512
Hs578T GDC0941 2
Hs 578T GDC-0980 2 72
0.001
 3445.0 3584.0 624.7
-3.0
 0.969 0.961 2.520
Hs578T GDC0980 2
Hs 578T GDC-0980 2 72
0.0032
 3386.5 3584.0 624.7
-2.49
 0.956 0.945 2.520
Hs578T GDC0980 2
Hs 578T GDC-0980 2 72
0.01
 3243.8 3584.0 624.7
-2.0
 0.922 0.905 2.520
Hs578T GDC0980 2
Hs 578T GDC-0980 2 72
0.032
 2780.0 3584.0 624.7
-1.49
 0.808 0.776 2.520
Hs578T GDC0980 2
Hs 578T GDC-0980 2 72
0.1
 2131.0 3584.0 624.7
-1.0
 0.627 0.595 2.520
Hs578T GDC0980 2
Hs 578T GDC-0980 2 72
0.32
 1277.0 3584.0 624.7
-0.495
 0.328 0.356 2.520
Hs578T GDC0980 2
Hs 578T GDC-0980 2 72
1.0
 922.5 3584.0 624.7
0.0
 0.167 0.257 2.520
Hs578T GDC0980 2
Hs 578T GDC-0980 2 72
3.2
 540.5 3584.0 624.7
0.505
 -0.056 0.151 2.520
Hs578T GDC0980 2
Hs 578T Omipalisib 2 72
0.001
 2479.5 3550.3 624.7
-3.0
 0.733 0.698 2.507
Hs578T GSK458 2
Hs 578T Omipalisib 2 72
0.0032
 2386.3 3550.3 624.7
-2.49
 0.707 0.672 2.507
Hs578T GSK458 2
Hs 578T Omipalisib 2 72
0.01
 1822.0 3550.3 624.7
-2.0
 0.533 0.513 2.507
Hs578T GSK458 2
Hs 578T Omipalisib 2 72
0.032
 1493.3 3550.3 624.7
-1.49
 0.416 0.421 2.507
Hs578T GSK458 2
Hs 578T Omipalisib 2 72
0.1
 1004.5 3550.3 624.7
-1.0
 0.209 0.283 2.507
Hs578T GSK458 2
Hs 578T Omipalisib 2 72
0.32
 577.8 3550.3 624.7
-0.495
 -0.031 0.163 2.507
Hs578T GSK458 2
Hs 578T Omipalisib 2 72
1.0
 258.0 3550.3 624.7
0.0
 -0.297 0.073 2.507
Hs578T GSK458 2
Hs 578T Omipalisib 2 72
3.2
 99.3 3550.3 624.7
0.505
 -0.520 0.028 2.507
Hs578T GSK458 2
Hs 578T KIN001-244 2 72
0.001
 3524.0 3546.3 624.7
-3.0
 0.995 0.994 2.505
Hs578T KIN001-244 2
Hs 578T KIN001-244 2 72
0.0032
 3367.0 3546.3 624.7
-2.49
 0.959 0.949 2.505
Hs578T KIN001-244 2
Hs 578T KIN001-244 2 72
0.01
 3552.8 3546.3 624.7
-2.0
 1.000 1.000 2.505
Hs578T KIN001-244 2
Hs 578T KIN001-244 2 72
0.032
 3397.5 3546.3 624.7
-1.49
 0.966 0.958 2.505
Hs578T KIN001-244 2
Hs 578T KIN001-244 2 72
0.1
 3550.0 3546.3 624.7
-1.0
 1.000 1.000 2.505
Hs578T KIN001-244 2
Hs 578T KIN001-244 2 72
0.32
 3488.3 3546.3 624.7
-0.495
 0.987 0.984 2.505
Hs578T KIN001-244 2
Hs 578T KIN001-244 2 72
1.0
 3240.5 3546.3 624.7
0.0
 0.929 0.914 2.505
Hs578T KIN001-244 2