Evaluation of the sensitivities of six triple-negative breast cancer (TNBC) cell lines to 23 different PI3K/AKT/mTOR inhibitors or to a MEK inhibitor (trametinib). Dataset 1 of 2: GR values. - Dataset (ID:20364)
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| Cell line | Drug name | Experimental replicate | Timepoint | Drug concentration | Live cell count | Average live cell count, DMSO control | Average live cell count (time = 0) | Log10(drug concentration) | GR value | Relative cell count (treatment versus DMSO) | Cell doublings (DMSO control) | Experiment name |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| HCC1806 | Sirolimus | 3 | 72 | 0.1 | 9292.5 | 12104.5 | 1273.3 | -1.0 | 0.844 | 0.768 | 3.249 | HCC1806 Rapamycin 0 3 72 |
| HCC1806 | Sirolimus | 3 | 72 | 1.0 | 9238.3 | 12104.5 | 1273.3 | 0.0 | 0.840 | 0.763 | 3.249 | HCC1806 Rapamycin 0 3 72 |
| HCC1806 | Sirolimus | 2 | 72 | 0.1 | 9292.5 | 12104.5 | 1643.3 | -1.0 | 0.825 | 0.768 | 2.881 | HCC1806 Rapamycin 0 2 72 |
| HCC1806 | Sirolimus | 3 | 72 | 0.032 | 9181.8 | 12104.5 | 1273.3 | -1.49 | 0.837 | 0.759 | 3.249 | HCC1806 Rapamycin 0 3 72 |
| HCC1806 | Sirolimus | 3 | 72 | 0.32 | 8965.0 | 12104.5 | 1273.3 | -0.495 | 0.823 | 0.741 | 3.249 | HCC1806 Rapamycin 0 3 72 |
| HCC1806 | Sirolimus | 2 | 72 | 0.32 | 8965.0 | 12104.5 | 1643.3 | -0.495 | 0.802 | 0.741 | 2.881 | HCC1806 Rapamycin 0 2 72 |
| HCC1806 | Sirolimus | 2 | 72 | 0.032 | 9181.8 | 12104.5 | 1643.3 | -1.49 | 0.817 | 0.759 | 2.881 | HCC1806 Rapamycin 0 2 72 |
| HCC1806 | Sirolimus | 2 | 72 | 3.2 | 8674.0 | 12104.5 | 1643.3 | 0.505 | 0.782 | 0.717 | 2.881 | HCC1806 Rapamycin 0 2 72 |
| HCC1806 | Sirolimus | 3 | 72 | 0.001 | 9616.0 | 12104.5 | 1273.3 | -3.0 | 0.863 | 0.794 | 3.249 | HCC1806 Rapamycin 0 3 72 |
| HCC1806 | Sirolimus | 3 | 72 | 0.01 | 9275.5 | 12104.5 | 1273.3 | -2.0 | 0.843 | 0.766 | 3.249 | HCC1806 Rapamycin 0 3 72 |
| HCC1806 | Sirolimus | 2 | 72 | 1.0 | 9238.3 | 12104.5 | 1643.3 | 0.0 | 0.821 | 0.763 | 2.881 | HCC1806 Rapamycin 0 2 72 |
| HCC1806 | Sirolimus | 1 | 72 | 0.032 | 9181.8 | 12104.5 | 1742.8 | -1.49 | 0.812 | 0.759 | 2.796 | HCC1806 Rapamycin 0 1 72 |
| HCC1806 | Sirolimus | 1 | 72 | 1.0 | 9238.3 | 12104.5 | 1742.8 | 0.0 | 0.816 | 0.763 | 2.796 | HCC1806 Rapamycin 0 1 72 |
| HCC1806 | Sirolimus | 1 | 72 | 0.32 | 8965.0 | 12104.5 | 1742.8 | -0.495 | 0.796 | 0.741 | 2.796 | HCC1806 Rapamycin 0 1 72 |
| HCC1806 | Sirolimus | 1 | 72 | 0.1 | 9292.5 | 12104.5 | 1742.8 | -1.0 | 0.820 | 0.768 | 2.796 | HCC1806 Rapamycin 0 1 72 |
| HCC1806 | Sirolimus | 2 | 72 | 0.001 | 9616.0 | 12104.5 | 1643.3 | -3.0 | 0.846 | 0.794 | 2.881 | HCC1806 Rapamycin 0 2 72 |
| HCC1806 | Sirolimus | 1 | 72 | 3.2 | 8674.0 | 12104.5 | 1742.8 | 0.505 | 0.775 | 0.717 | 2.796 | HCC1806 Rapamycin 0 1 72 |
| HCC1806 | Sirolimus | 1 | 72 | 0.0032 | 9333.0 | 12104.5 | 1742.8 | -2.49 | 0.822 | 0.771 | 2.796 | HCC1806 Rapamycin 0 1 72 |
| HCC1806 | Sirolimus | 1 | 72 | 0.001 | 9616.0 | 12104.5 | 1742.8 | -3.0 | 0.842 | 0.794 | 2.796 | HCC1806 Rapamycin 0 1 72 |
| HCC1806 | Sirolimus | 2 | 72 | 0.01 | 9275.5 | 12104.5 | 1643.3 | -2.0 | 0.823 | 0.766 | 2.881 | HCC1806 Rapamycin 0 2 72 |
| HCC1806 | Sirolimus | 2 | 72 | 0.0032 | 9333.0 | 12104.5 | 1643.3 | -2.49 | 0.827 | 0.771 | 2.881 | HCC1806 Rapamycin 0 2 72 |
| HCC1806 | Sirolimus | 3 | 72 | 0.0032 | 9333.0 | 12104.5 | 1273.3 | -2.49 | 0.846 | 0.771 | 3.249 | HCC1806 Rapamycin 0 3 72 |
| HCC1806 | Sirolimus | 1 | 72 | 0.01 | 9275.5 | 12104.5 | 1742.8 | -2.0 | 0.818 | 0.766 | 2.796 | HCC1806 Rapamycin 0 1 72 |
| HCC1806 | Sirolimus | 3 | 72 | 3.2 | 8674.0 | 12104.5 | 1273.3 | 0.505 | 0.805 | 0.717 | 3.249 | HCC1806 Rapamycin 0 3 72 |
| HCC1806 | WYE-125132 | 2 | 72 | 0.001 | 11365.0 | 12050.8 | 1643.3 | -3.0 | 0.960 | 0.943 | 2.874 | HCC1806 WYE125132 0 2 72 |