Evaluation of the sensitivities of six triple-negative breast cancer (TNBC) cell lines to 23 different PI3K/AKT/mTOR inhibitors or to a MEK inhibitor (trametinib). Dataset 1 of 2: GR values. - Dataset (ID:20364)
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| Cell line | Drug name | Experimental replicate | Timepoint | Drug concentration | Live cell count | Average live cell count, DMSO control | Average live cell count (time = 0) | Log10(drug concentration) | GR value | Relative cell count (treatment versus DMSO) | Cell doublings (DMSO control) | Experiment name |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| HCC1806 | XL147 | 1 | 72 | 3.2 | 12161.5 | 11581.0 | 1742.8 | 0.505 | 1.040 | 1.050 | 2.732 | HCC1806 XL147 0 1 72 |
| HCC1806 | XL147 | 3 | 72 | 3.2 | 12161.5 | 11581.0 | 1273.3 | 0.505 | 1.030 | 1.050 | 3.185 | HCC1806 XL147 0 3 72 |
| HCC1806 | XL147 | 2 | 72 | 3.2 | 12161.5 | 11581.0 | 1643.3 | 0.505 | 1.040 | 1.050 | 2.817 | HCC1806 XL147 0 2 72 |
| HCC1806 | AZD-6482 | 1 | 72 | 0.1 | 12053.8 | 11709.8 | 1742.8 | -1.0 | 1.020 | 1.030 | 2.748 | HCC1806 AZD6482 0 1 72 |
| HCC1806 | AZD-6482 | 3 | 72 | 0.1 | 12053.8 | 11709.8 | 1273.3 | -1.0 | 1.020 | 1.030 | 3.201 | HCC1806 AZD6482 0 3 72 |
| HCC1806 | AZD-6482 | 2 | 72 | 0.1 | 12053.8 | 11709.8 | 1643.3 | -1.0 | 1.020 | 1.030 | 2.833 | HCC1806 AZD6482 0 2 72 |
| HCC1806 | CAL-101 | 2 | 72 | 3.2 | 11994.0 | 11282.8 | 1643.3 | 0.505 | 1.040 | 1.060 | 2.779 | HCC1806 CAL101 0 2 72 |
| HCC1806 | CAL-101 | 3 | 72 | 3.2 | 11994.0 | 11282.8 | 1273.3 | 0.505 | 1.040 | 1.060 | 3.147 | HCC1806 CAL101 0 3 72 |
| HCC1806 | CAL-101 | 1 | 72 | 3.2 | 11994.0 | 11282.8 | 1742.8 | 0.505 | 1.050 | 1.060 | 2.695 | HCC1806 CAL101 0 1 72 |
| HCC1806 | AZD-6482 | 1 | 72 | 3.2 | 11967.3 | 11709.8 | 1742.8 | 0.505 | 1.020 | 1.020 | 2.748 | HCC1806 AZD6482 0 1 72 |
| HCC1806 | AZD-6482 | 3 | 72 | 3.2 | 11967.3 | 11709.8 | 1273.3 | 0.505 | 1.010 | 1.020 | 3.201 | HCC1806 AZD6482 0 3 72 |
| HCC1806 | AZD-6482 | 2 | 72 | 3.2 | 11967.3 | 11709.8 | 1643.3 | 0.505 | 1.020 | 1.020 | 2.833 | HCC1806 AZD6482 0 2 72 |
| HCC1806 | AS605240 | 3 | 72 | 0.032 | 11947.8 | 11546.3 | 1273.3 | -1.49 | 1.020 | 1.030 | 3.181 | HCC1806 AS605240 0 3 72 |
| HCC1806 | AS605240 | 2 | 72 | 0.032 | 11947.8 | 11546.3 | 1643.3 | -1.49 | 1.020 | 1.030 | 2.813 | HCC1806 AS605240 0 2 72 |
| HCC1806 | AS605240 | 1 | 72 | 0.032 | 11947.8 | 11546.3 | 1742.8 | -1.49 | 1.030 | 1.030 | 2.728 | HCC1806 AS605240 0 1 72 |
| HCC1806 | AZD-6482 | 1 | 72 | 0.032 | 11940.3 | 11709.8 | 1742.8 | -1.49 | 1.010 | 1.020 | 2.748 | HCC1806 AZD6482 0 1 72 |
| HCC1806 | AZD-6482 | 3 | 72 | 0.032 | 11940.3 | 11709.8 | 1273.3 | -1.49 | 1.010 | 1.020 | 3.201 | HCC1806 AZD6482 0 3 72 |
| HCC1806 | AZD-6482 | 2 | 72 | 0.032 | 11940.3 | 11709.8 | 1643.3 | -1.49 | 1.010 | 1.020 | 2.833 | HCC1806 AZD6482 0 2 72 |
| HCC1806 | XL147 | 2 | 72 | 1.0 | 11919.8 | 11581.0 | 1643.3 | 0.0 | 1.020 | 1.030 | 2.817 | HCC1806 XL147 0 2 72 |
| HCC1806 | XL147 | 3 | 72 | 1.0 | 11919.8 | 11581.0 | 1273.3 | 0.0 | 1.020 | 1.030 | 3.185 | HCC1806 XL147 0 3 72 |
| HCC1806 | XL147 | 1 | 72 | 1.0 | 11919.8 | 11581.0 | 1742.8 | 0.0 | 1.020 | 1.030 | 2.732 | HCC1806 XL147 0 1 72 |
| HCC1806 | Pictilisib | 3 | 72 | 0.032 | 11917.8 | 11984.0 | 1273.3 | -1.49 | 0.997 | 0.994 | 3.234 | HCC1806 GDC0941 0 3 72 |
| HCC1806 | Pictilisib | 1 | 72 | 0.032 | 11917.8 | 11984.0 | 1742.8 | -1.49 | 0.996 | 0.994 | 2.782 | HCC1806 GDC0941 0 1 72 |
| HCC1806 | Pictilisib | 2 | 72 | 0.032 | 11917.8 | 11984.0 | 1643.3 | -1.49 | 0.996 | 0.994 | 2.866 | HCC1806 GDC0941 0 2 72 |
| HCC1806 | KIN001-244 | 3 | 72 | 0.001 | 11912.3 | 11660.3 | 1273.3 | -3.0 | 1.010 | 1.020 | 3.195 | HCC1806 KIN001-244 0 3 72 |