Evaluation of the sensitivities of six triple-negative breast cancer (TNBC) cell lines to 23 different PI3K/AKT/mTOR inhibitors or to a MEK inhibitor (trametinib). Dataset 1 of 2: GR values. - Dataset (ID:20364)

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Cell line Drug name Experimental replicate Timepoint Drug concentration Live cell count Average live cell count, DMSO control Average live cell count (time = 0) Log10(drug concentration) GR value Relative cell count (treatment versus DMSO) Cell doublings (DMSO control) Experiment name
HCC70 Torin2 2 72
0.032
 1533.8 2562.3 722.8
-1.49
 0.510 0.599 1.826
HCC70 Torin2 0 2 72
HCC70 Torin2 2 72
0.1
 1355.8 2562.3 722.8
-1.0
 0.411 0.529 1.826
HCC70 Torin2 0 2 72
HCC70 Torin2 2 72
0.32
 830.0 2562.3 722.8
-0.495
 0.079 0.324 1.826
HCC70 Torin2 0 2 72
HCC70 Torin2 2 72
1.0
 483.8 2562.3 722.8
0.0
 -0.197 0.189 1.826
HCC70 Torin2 0 2 72
HCC70 Torin2 2 72
3.2
 187.8 2562.3 722.8
0.505
 -0.522 0.073 1.826
HCC70 Torin2 0 2 72
HCC70 Trametinib 2 72
0.001
 2054.3 2383.8 722.8
-3.0
 0.834 0.862 1.721
HCC70 Trametinib 0 2 72
HCC70 Trametinib 2 72
0.0032
 1913.0 2383.8 722.8
-2.49
 0.760 0.803 1.721
HCC70 Trametinib 0 2 72
HCC70 Trametinib 2 72
0.01
 1765.8 2383.8 722.8
-2.0
 0.680 0.741 1.721
HCC70 Trametinib 0 2 72
HCC70 Trametinib 2 72
0.032
 1708.0 2383.8 722.8
-1.49
 0.648 0.717 1.721
HCC70 Trametinib 0 2 72
HCC70 Trametinib 2 72
0.1
 1459.0 2383.8 722.8
-1.0
 0.504 0.612 1.721
HCC70 Trametinib 0 2 72
HCC70 Trametinib 2 72
0.32
 1388.5 2383.8 722.8
-0.495
 0.461 0.582 1.721
HCC70 Trametinib 0 2 72
HCC70 Trametinib 2 72
1.0
 1469.3 2383.8 722.8
0.0
 0.510 0.616 1.721
HCC70 Trametinib 0 2 72
HCC70 Trametinib 2 72
3.2
 1458.8 2383.8 722.8
0.505
 0.504 0.612 1.721
HCC70 Trametinib 0 2 72
HCC70 WYE-125132 2 72
0.001
 2297.5 2308.5 722.8
-3.0
 0.994 0.995 1.675
HCC70 WYE125132 0 2 72
HCC70 WYE-125132 2 72
0.0032
 2162.8 2308.5 722.8
-2.49
 0.924 0.937 1.675
HCC70 WYE125132 0 2 72
HCC70 WYE-125132 2 72
0.01
 2029.3 2308.5 722.8
-2.0
 0.852 0.879 1.675
HCC70 WYE125132 0 2 72
HCC70 WYE-125132 2 72
0.032
 1724.8 2308.5 722.8
-1.49
 0.681 0.747 1.675
HCC70 WYE125132 0 2 72
HCC70 WYE-125132 2 72
0.1
 1462.3 2308.5 722.8
-1.0
 0.523 0.633 1.675
HCC70 WYE125132 0 2 72
HCC70 WYE-125132 2 72
0.32
 1397.0 2308.5 722.8
-0.495
 0.482 0.605 1.675
HCC70 WYE125132 0 2 72
HCC70 WYE-125132 2 72
1.0
 1402.5 2308.5 722.8
0.0
 0.485 0.608 1.675
HCC70 WYE125132 0 2 72
HCC70 WYE-125132 2 72
3.2
 1379.5 2308.5 722.8
0.505
 0.471 0.598 1.675
HCC70 WYE125132 0 2 72
HCC70 XL147 2 72
0.001
 2298.8 2497.8 722.8
-3.0
 0.909 0.920 1.789
HCC70 XL147 0 2 72
HCC70 XL147 2 72
0.0032
 2420.3 2497.8 722.8
-2.49
 0.965 0.969 1.789
HCC70 XL147 0 2 72
HCC70 XL147 2 72
0.01
 2445.3 2497.8 722.8
-2.0
 0.976 0.979 1.789
HCC70 XL147 0 2 72
HCC70 XL147 2 72
0.032
 2341.8 2497.8 722.8
-1.49
 0.929 0.938 1.789
HCC70 XL147 0 2 72