Evaluation of the sensitivities of six triple-negative breast cancer (TNBC) cell lines to 23 different PI3K/AKT/mTOR inhibitors or to a MEK inhibitor (trametinib). Dataset 1 of 2: GR values. - Dataset (ID:20364)
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| Cell line | Drug name | Experimental replicate | Timepoint | Drug concentration | Live cell count | Average live cell count, DMSO control | Average live cell count (time = 0) | Log10(drug concentration) | GR value | Relative cell count (treatment versus DMSO) | Cell doublings (DMSO control) | Experiment name |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| HCC70 | KIN001-244 | 1 | 72 | 0.0032 | 3343.5 | 3263.0 | 1279.8 | -2.49 | 1.040 | 1.020 | 1.350 | HCC70 KIN001-244 0 1 72 |
| HCC70 | KIN001-244 | 1 | 72 | 0.01 | 3132.8 | 3263.0 | 1279.8 | -2.0 | 0.941 | 0.960 | 1.350 | HCC70 KIN001-244 0 1 72 |
| HCC70 | KIN001-244 | 1 | 72 | 0.032 | 3335.5 | 3263.0 | 1279.8 | -1.49 | 1.030 | 1.020 | 1.350 | HCC70 KIN001-244 0 1 72 |
| HCC70 | KIN001-244 | 1 | 72 | 0.1 | 3346.5 | 3263.0 | 1279.8 | -1.0 | 1.040 | 1.030 | 1.350 | HCC70 KIN001-244 0 1 72 |
| HCC70 | KIN001-244 | 1 | 72 | 0.32 | 3230.5 | 3263.0 | 1279.8 | -0.495 | 0.985 | 0.990 | 1.350 | HCC70 KIN001-244 0 1 72 |
| HCC70 | KIN001-244 | 1 | 72 | 1.0 | 3187.8 | 3263.0 | 1279.8 | 0.0 | 0.966 | 0.977 | 1.350 | HCC70 KIN001-244 0 1 72 |
| HCC70 | KIN001-244 | 1 | 72 | 3.2 | 3021.3 | 3263.0 | 1279.8 | 0.505 | 0.889 | 0.926 | 1.350 | HCC70 KIN001-244 0 1 72 |
| HCC70 | MK2206 | 1 | 72 | 0.001 | 3477.0 | 3483.3 | 1279.8 | -3.0 | 0.998 | 0.998 | 1.444 | HCC70 MK2206 0 1 72 |
| HCC70 | MK2206 | 1 | 72 | 0.0032 | 3306.0 | 3483.3 | 1279.8 | -2.49 | 0.929 | 0.949 | 1.444 | HCC70 MK2206 0 1 72 |
| HCC70 | MK2206 | 1 | 72 | 0.01 | 3245.0 | 3483.3 | 1279.8 | -2.0 | 0.904 | 0.932 | 1.444 | HCC70 MK2206 0 1 72 |
| HCC70 | MK2206 | 1 | 72 | 0.032 | 3119.3 | 3483.3 | 1279.8 | -1.49 | 0.853 | 0.895 | 1.444 | HCC70 MK2206 0 1 72 |
| HCC70 | MK2206 | 1 | 72 | 0.1 | 2977.5 | 3483.3 | 1279.8 | -1.0 | 0.794 | 0.855 | 1.444 | HCC70 MK2206 0 1 72 |
| HCC70 | MK2206 | 1 | 72 | 0.32 | 2261.3 | 3483.3 | 1279.8 | -0.495 | 0.483 | 0.649 | 1.444 | HCC70 MK2206 0 1 72 |
| HCC70 | MK2206 | 1 | 72 | 1.0 | 1648.0 | 3483.3 | 1279.8 | 0.0 | 0.191 | 0.473 | 1.444 | HCC70 MK2206 0 1 72 |
| HCC70 | MK2206 | 1 | 72 | 3.2 | 1231.0 | 3483.3 | 1279.8 | 0.505 | -0.027 | 0.353 | 1.444 | HCC70 MK2206 0 1 72 |
| HCC70 | PI103 | 1 | 72 | 0.001 | 3066.0 | 3161.3 | 1279.8 | -3.0 | 0.954 | 0.970 | 1.305 | HCC70 PI103 0 1 72 |
| HCC70 | PI103 | 1 | 72 | 0.0032 | 3251.5 | 3161.3 | 1279.8 | -2.49 | 1.040 | 1.030 | 1.305 | HCC70 PI103 0 1 72 |
| HCC70 | PI103 | 1 | 72 | 0.01 | 3323.0 | 3161.3 | 1279.8 | -2.0 | 1.080 | 1.050 | 1.305 | HCC70 PI103 0 1 72 |
| HCC70 | PI103 | 1 | 72 | 0.032 | 3551.3 | 3161.3 | 1279.8 | -1.49 | 1.190 | 1.120 | 1.305 | HCC70 PI103 0 1 72 |
| HCC70 | PI103 | 1 | 72 | 0.1 | 3244.0 | 3161.3 | 1279.8 | -1.0 | 1.040 | 1.030 | 1.305 | HCC70 PI103 0 1 72 |
| HCC70 | PI103 | 1 | 72 | 0.32 | 3016.5 | 3161.3 | 1279.8 | -0.495 | 0.929 | 0.954 | 1.305 | HCC70 PI103 0 1 72 |
| HCC70 | PI103 | 1 | 72 | 1.0 | 2224.3 | 3161.3 | 1279.8 | 0.0 | 0.528 | 0.704 | 1.305 | HCC70 PI103 0 1 72 |
| HCC70 | PI103 | 1 | 72 | 3.2 | 1262.8 | 3161.3 | 1279.8 | 0.505 | -0.010 | 0.399 | 1.305 | HCC70 PI103 0 1 72 |
| HCC70 | PIK-93 | 1 | 72 | 0.001 | 3210.5 | 3477.0 | 1279.8 | -3.0 | 0.892 | 0.923 | 1.442 | HCC70 PIK93 0 1 72 |
| HCC70 | PIK-93 | 1 | 72 | 0.0032 | 3227.0 | 3477.0 | 1279.8 | -2.49 | 0.899 | 0.928 | 1.442 | HCC70 PIK93 0 1 72 |