Evaluation of the sensitivities of six triple-negative breast cancer (TNBC) cell lines to 23 different PI3K/AKT/mTOR inhibitors or to a MEK inhibitor (trametinib). Dataset 1 of 2: GR values. - Dataset (ID:20364)
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| Cell line | Drug name | Experimental replicate | Timepoint | Drug concentration | Live cell count | Average live cell count, DMSO control | Average live cell count (time = 0) | Log10(drug concentration) | GR value | Relative cell count (treatment versus DMSO) | Cell doublings (DMSO control) | Experiment name |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| HCC38 | AZD-6482 | 3 | 72 | 1.0 | 2789.8 | 3159.3 | 1180.5 | 0.0 | 0.832 | 0.883 | 1.420 | HCC38 AZD6482 0 3 72 |
| HCC38 | AZD-6482 | 3 | 72 | 3.2 | 2765.8 | 3159.3 | 1180.5 | 0.505 | 0.821 | 0.875 | 1.420 | HCC38 AZD6482 0 3 72 |
| HCC38 | AZD8055 | 3 | 72 | 0.001 | 3024.8 | 3151.3 | 1180.5 | -3.0 | 0.943 | 0.960 | 1.417 | HCC38 AZD8055 0 3 72 |
| HCC38 | AZD8055 | 3 | 72 | 0.0032 | 2957.0 | 3151.3 | 1180.5 | -2.49 | 0.912 | 0.938 | 1.417 | HCC38 AZD8055 0 3 72 |
| HCC38 | AZD8055 | 3 | 72 | 0.01 | 2780.0 | 3151.3 | 1180.5 | -2.0 | 0.831 | 0.882 | 1.417 | HCC38 AZD8055 0 3 72 |
| HCC38 | AZD8055 | 3 | 72 | 0.032 | 2334.0 | 3151.3 | 1180.5 | -1.49 | 0.618 | 0.741 | 1.417 | HCC38 AZD8055 0 3 72 |
| HCC38 | AZD8055 | 3 | 72 | 0.1 | 1727.0 | 3151.3 | 1180.5 | -1.0 | 0.308 | 0.548 | 1.417 | HCC38 AZD8055 0 3 72 |
| HCC38 | AZD8055 | 3 | 72 | 0.32 | 1341.0 | 3151.3 | 1180.5 | -0.495 | 0.094 | 0.426 | 1.417 | HCC38 AZD8055 0 3 72 |
| HCC38 | AZD8055 | 3 | 72 | 1.0 | 1247.5 | 3151.3 | 1180.5 | 0.0 | 0.040 | 0.396 | 1.417 | HCC38 AZD8055 0 3 72 |
| HCC38 | AZD8055 | 3 | 72 | 3.2 | 1235.5 | 3151.3 | 1180.5 | 0.505 | 0.033 | 0.392 | 1.417 | HCC38 AZD8055 0 3 72 |
| HCC38 | Dactolisib | 3 | 72 | 0.001 | 2969.3 | 3265.3 | 1180.5 | -3.0 | 0.875 | 0.909 | 1.468 | HCC38 BEZ235 0 3 72 |
| HCC38 | Dactolisib | 3 | 72 | 0.0032 | 2530.8 | 3265.3 | 1180.5 | -2.49 | 0.681 | 0.775 | 1.468 | HCC38 BEZ235 0 3 72 |
| HCC38 | Dactolisib | 3 | 72 | 0.01 | 1985.0 | 3265.3 | 1180.5 | -2.0 | 0.425 | 0.608 | 1.468 | HCC38 BEZ235 0 3 72 |
| HCC38 | Dactolisib | 3 | 72 | 0.032 | 1547.0 | 3265.3 | 1180.5 | -1.49 | 0.202 | 0.474 | 1.468 | HCC38 BEZ235 0 3 72 |
| HCC38 | Dactolisib | 3 | 72 | 0.1 | 1295.5 | 3265.3 | 1180.5 | -1.0 | 0.065 | 0.397 | 1.468 | HCC38 BEZ235 0 3 72 |
| HCC38 | Dactolisib | 3 | 72 | 0.32 | 1139.0 | 3265.3 | 1180.5 | -0.495 | -0.024 | 0.349 | 1.468 | HCC38 BEZ235 0 3 72 |
| HCC38 | Dactolisib | 3 | 72 | 1.0 | 951.0 | 3265.3 | 1180.5 | 0.0 | -0.137 | 0.291 | 1.468 | HCC38 BEZ235 0 3 72 |
| HCC38 | Dactolisib | 3 | 72 | 3.2 | 855.8 | 3265.3 | 1180.5 | 0.505 | -0.197 | 0.262 | 1.468 | HCC38 BEZ235 0 3 72 |
| HCC38 | Buparlisib | 3 | 72 | 0.001 | 3052.5 | 3184.0 | 1180.5 | -3.0 | 0.942 | 0.959 | 1.431 | HCC38 BKM120 0 3 72 |
| HCC38 | Buparlisib | 3 | 72 | 0.0032 | 3075.0 | 3184.0 | 1180.5 | -2.49 | 0.952 | 0.966 | 1.431 | HCC38 BKM120 0 3 72 |
| HCC38 | Buparlisib | 3 | 72 | 0.01 | 2986.3 | 3184.0 | 1180.5 | -2.0 | 0.912 | 0.938 | 1.431 | HCC38 BKM120 0 3 72 |
| HCC38 | Buparlisib | 3 | 72 | 0.032 | 3081.0 | 3184.0 | 1180.5 | -1.49 | 0.955 | 0.968 | 1.431 | HCC38 BKM120 0 3 72 |
| HCC38 | Buparlisib | 3 | 72 | 0.1 | 2993.5 | 3184.0 | 1180.5 | -1.0 | 0.916 | 0.940 | 1.431 | HCC38 BKM120 0 3 72 |
| HCC38 | Buparlisib | 3 | 72 | 0.32 | 2696.8 | 3184.0 | 1180.5 | -0.495 | 0.781 | 0.847 | 1.431 | HCC38 BKM120 0 3 72 |
| HCC38 | Buparlisib | 3 | 72 | 1.0 | 1719.3 | 3184.0 | 1180.5 | 0.0 | 0.300 | 0.540 | 1.431 | HCC38 BKM120 0 3 72 |