Evaluation of the sensitivities of six triple-negative breast cancer (TNBC) cell lines to 23 different PI3K/AKT/mTOR inhibitors or to a MEK inhibitor (trametinib). Dataset 1 of 2: GR values. - Dataset (ID:20364)
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| Cell line | Drug name | Experimental replicate | Timepoint | Drug concentration | Live cell count | Average live cell count, DMSO control | Average live cell count (time = 0) | Log10(drug concentration) | GR value | Relative cell count (treatment versus DMSO) | Cell doublings (DMSO control) | Experiment name |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| HCC38 | XL147 | 2 | 72 | 0.32 | 3170.8 | 3158.8 | 690.5 | -0.495 | 1.000 | 1.000 | 2.194 | HCC38 XL147 0 2 72 |
| HCC38 | XL147 | 2 | 72 | 1.0 | 3069.0 | 3158.8 | 690.5 | 0.0 | 0.974 | 0.972 | 2.194 | HCC38 XL147 0 2 72 |
| HCC38 | XL147 | 2 | 72 | 3.2 | 2948.5 | 3158.8 | 690.5 | 0.505 | 0.938 | 0.933 | 2.194 | HCC38 XL147 0 2 72 |
| HCC38 | ZSTK474 | 2 | 72 | 0.001 | 3202.3 | 3291.0 | 690.5 | -3.0 | 0.976 | 0.973 | 2.253 | HCC38 ZSTK474 0 2 72 |
| HCC38 | ZSTK474 | 2 | 72 | 0.0032 | 3131.3 | 3291.0 | 690.5 | -2.49 | 0.956 | 0.951 | 2.253 | HCC38 ZSTK474 0 2 72 |
| HCC38 | ZSTK474 | 2 | 72 | 0.01 | 3051.3 | 3291.0 | 690.5 | -2.0 | 0.934 | 0.927 | 2.253 | HCC38 ZSTK474 0 2 72 |
| HCC38 | ZSTK474 | 2 | 72 | 0.032 | 2978.8 | 3291.0 | 690.5 | -1.49 | 0.913 | 0.905 | 2.253 | HCC38 ZSTK474 0 2 72 |
| HCC38 | ZSTK474 | 2 | 72 | 0.1 | 2849.8 | 3291.0 | 690.5 | -1.0 | 0.876 | 0.866 | 2.253 | HCC38 ZSTK474 0 2 72 |
| HCC38 | ZSTK474 | 2 | 72 | 0.32 | 2201.3 | 3291.0 | 690.5 | -0.495 | 0.673 | 0.669 | 2.253 | HCC38 ZSTK474 0 2 72 |
| HCC38 | ZSTK474 | 2 | 72 | 1.0 | 1966.3 | 3291.0 | 690.5 | 0.0 | 0.591 | 0.597 | 2.253 | HCC38 ZSTK474 0 2 72 |
| HCC38 | ZSTK474 | 2 | 72 | 3.2 | 1464.3 | 3291.0 | 690.5 | 0.505 | 0.396 | 0.445 | 2.253 | HCC38 ZSTK474 0 2 72 |
| HCC38 | AS605240 | 3 | 72 | 0.001 | 3065.8 | 2994.3 | 1180.5 | -3.0 | 1.040 | 1.020 | 1.343 | HCC38 AS605240 0 3 72 |
| HCC38 | AS605240 | 3 | 72 | 0.0032 | 2991.0 | 2994.3 | 1180.5 | -2.49 | 0.998 | 0.999 | 1.343 | HCC38 AS605240 0 3 72 |
| HCC38 | AS605240 | 3 | 72 | 0.01 | 3058.0 | 2994.3 | 1180.5 | -2.0 | 1.030 | 1.020 | 1.343 | HCC38 AS605240 0 3 72 |
| HCC38 | AS605240 | 3 | 72 | 0.032 | 3071.8 | 2994.3 | 1180.5 | -1.49 | 1.040 | 1.030 | 1.343 | HCC38 AS605240 0 3 72 |
| HCC38 | AS605240 | 3 | 72 | 0.1 | 3083.5 | 2994.3 | 1180.5 | -1.0 | 1.040 | 1.030 | 1.343 | HCC38 AS605240 0 3 72 |
| HCC38 | AS605240 | 3 | 72 | 0.32 | 3034.0 | 2994.3 | 1180.5 | -0.495 | 1.020 | 1.010 | 1.343 | HCC38 AS605240 0 3 72 |
| HCC38 | AS605240 | 3 | 72 | 1.0 | 2963.5 | 2994.3 | 1180.5 | 0.0 | 0.985 | 0.990 | 1.343 | HCC38 AS605240 0 3 72 |
| HCC38 | AS605240 | 3 | 72 | 3.2 | 2910.0 | 2994.3 | 1180.5 | 0.505 | 0.958 | 0.972 | 1.343 | HCC38 AS605240 0 3 72 |
| HCC38 | AZD-6482 | 3 | 72 | 0.001 | 3207.3 | 3159.3 | 1180.5 | -3.0 | 1.020 | 1.020 | 1.420 | HCC38 AZD6482 0 3 72 |
| HCC38 | AZD-6482 | 3 | 72 | 0.0032 | 3009.5 | 3159.3 | 1180.5 | -2.49 | 0.933 | 0.953 | 1.420 | HCC38 AZD6482 0 3 72 |
| HCC38 | AZD-6482 | 3 | 72 | 0.01 | 3134.5 | 3159.3 | 1180.5 | -2.0 | 0.989 | 0.992 | 1.420 | HCC38 AZD6482 0 3 72 |
| HCC38 | AZD-6482 | 3 | 72 | 0.032 | 3091.3 | 3159.3 | 1180.5 | -1.49 | 0.970 | 0.978 | 1.420 | HCC38 AZD6482 0 3 72 |
| HCC38 | AZD-6482 | 3 | 72 | 0.1 | 3180.5 | 3159.3 | 1180.5 | -1.0 | 1.010 | 1.010 | 1.420 | HCC38 AZD6482 0 3 72 |
| HCC38 | AZD-6482 | 3 | 72 | 0.32 | 2971.5 | 3159.3 | 1180.5 | -0.495 | 0.916 | 0.941 | 1.420 | HCC38 AZD6482 0 3 72 |