Evaluation of the sensitivities of six triple-negative breast cancer (TNBC) cell lines to 23 different PI3K/AKT/mTOR inhibitors or to a MEK inhibitor (trametinib). Dataset 1 of 2: GR values. - Dataset (ID:20364)
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| Cell line | Drug name | Experimental replicate | Timepoint | Drug concentration | Live cell count | Average live cell count, DMSO control | Average live cell count (time = 0) | Log10(drug concentration) | GR value | Relative cell count (treatment versus DMSO) | Cell doublings (DMSO control) | Experiment name |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| HCC38 | KIN001-244 | 1 | 72 | 0.01 | 4429.3 | 4361.0 | 1295.5 | -2.0 | 1.020 | 1.020 | 1.751 | HCC38 KIN001-244 0 1 72 |
| HCC38 | KIN001-244 | 1 | 72 | 0.032 | 4196.5 | 4361.0 | 1295.5 | -1.49 | 0.957 | 0.962 | 1.751 | HCC38 KIN001-244 0 1 72 |
| HCC38 | KIN001-244 | 1 | 72 | 0.1 | 4201.0 | 4361.0 | 1295.5 | -1.0 | 0.958 | 0.963 | 1.751 | HCC38 KIN001-244 0 1 72 |
| HCC38 | KIN001-244 | 1 | 72 | 0.32 | 4292.3 | 4361.0 | 1295.5 | -0.495 | 0.982 | 0.984 | 1.751 | HCC38 KIN001-244 0 1 72 |
| HCC38 | KIN001-244 | 1 | 72 | 1.0 | 4025.3 | 4361.0 | 1295.5 | 0.0 | 0.911 | 0.923 | 1.751 | HCC38 KIN001-244 0 1 72 |
| HCC38 | KIN001-244 | 1 | 72 | 3.2 | 3965.3 | 4361.0 | 1295.5 | 0.505 | 0.894 | 0.909 | 1.751 | HCC38 KIN001-244 0 1 72 |
| HCC38 | MK2206 | 1 | 72 | 0.001 | 4250.0 | 4477.3 | 1295.5 | -3.0 | 0.943 | 0.949 | 1.789 | HCC38 MK2206 0 1 72 |
| HCC38 | MK2206 | 1 | 72 | 0.0032 | 4362.5 | 4477.3 | 1295.5 | -2.49 | 0.971 | 0.974 | 1.789 | HCC38 MK2206 0 1 72 |
| HCC38 | MK2206 | 1 | 72 | 0.01 | 4328.5 | 4477.3 | 1295.5 | -2.0 | 0.963 | 0.967 | 1.789 | HCC38 MK2206 0 1 72 |
| HCC38 | MK2206 | 1 | 72 | 0.032 | 4206.3 | 4477.3 | 1295.5 | -1.49 | 0.931 | 0.939 | 1.789 | HCC38 MK2206 0 1 72 |
| HCC38 | MK2206 | 1 | 72 | 0.1 | 4177.5 | 4477.3 | 1295.5 | -1.0 | 0.924 | 0.933 | 1.789 | HCC38 MK2206 0 1 72 |
| HCC38 | MK2206 | 1 | 72 | 0.32 | 3977.0 | 4477.3 | 1295.5 | -0.495 | 0.872 | 0.888 | 1.789 | HCC38 MK2206 0 1 72 |
| HCC38 | MK2206 | 1 | 72 | 1.0 | 3795.3 | 4477.3 | 1295.5 | 0.0 | 0.824 | 0.848 | 1.789 | HCC38 MK2206 0 1 72 |
| HCC38 | MK2206 | 1 | 72 | 3.2 | 3339.3 | 4477.3 | 1295.5 | 0.505 | 0.698 | 0.746 | 1.789 | HCC38 MK2206 0 1 72 |
| HCC38 | PI103 | 1 | 72 | 0.001 | 4328.8 | 4454.3 | 1295.5 | -3.0 | 0.968 | 0.972 | 1.782 | HCC38 PI103 0 1 72 |
| HCC38 | PI103 | 1 | 72 | 0.0032 | 4378.8 | 4454.3 | 1295.5 | -2.49 | 0.981 | 0.983 | 1.782 | HCC38 PI103 0 1 72 |
| HCC38 | PI103 | 1 | 72 | 0.01 | 4350.3 | 4454.3 | 1295.5 | -2.0 | 0.974 | 0.977 | 1.782 | HCC38 PI103 0 1 72 |
| HCC38 | PI103 | 1 | 72 | 0.032 | 4356.0 | 4454.3 | 1295.5 | -1.49 | 0.975 | 0.978 | 1.782 | HCC38 PI103 0 1 72 |
| HCC38 | PI103 | 1 | 72 | 0.1 | 4161.3 | 4454.3 | 1295.5 | -1.0 | 0.925 | 0.934 | 1.782 | HCC38 PI103 0 1 72 |
| HCC38 | PI103 | 1 | 72 | 0.32 | 3359.0 | 4454.3 | 1295.5 | -0.495 | 0.707 | 0.754 | 1.782 | HCC38 PI103 0 1 72 |
| HCC38 | PI103 | 1 | 72 | 1.0 | 2467.8 | 4454.3 | 1295.5 | 0.0 | 0.436 | 0.554 | 1.782 | HCC38 PI103 0 1 72 |
| HCC38 | PI103 | 1 | 72 | 3.2 | 1853.0 | 4454.3 | 1295.5 | 0.505 | 0.222 | 0.416 | 1.782 | HCC38 PI103 0 1 72 |
| HCC38 | PIK-93 | 1 | 72 | 0.001 | 4367.3 | 4331.0 | 1295.5 | -3.0 | 1.010 | 1.010 | 1.741 | HCC38 PIK93 0 1 72 |
| HCC38 | PIK-93 | 1 | 72 | 0.0032 | 4262.8 | 4331.0 | 1295.5 | -2.49 | 0.982 | 0.984 | 1.741 | HCC38 PIK93 0 1 72 |
| HCC38 | PIK-93 | 1 | 72 | 0.01 | 4355.5 | 4331.0 | 1295.5 | -2.0 | 1.010 | 1.010 | 1.741 | HCC38 PIK93 0 1 72 |