Evaluation of the sensitivities of six triple-negative breast cancer (TNBC) cell lines to 23 different PI3K/AKT/mTOR inhibitors or to a MEK inhibitor (trametinib). Dataset 1 of 2: GR values. - Dataset (ID:20364)
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| Cell line | Drug name | Experimental replicate | Timepoint | Drug concentration | Live cell count | Average live cell count, DMSO control | Average live cell count (time = 0) | Log10(drug concentration) | GR value | Relative cell count (treatment versus DMSO) | Cell doublings (DMSO control) | Experiment name |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| HCC38 | Pictilisib | 1 | 72 | 0.0032 | 4325.0 | 4386.3 | 1295.5 | -2.49 | 0.984 | 0.986 | 1.759 | HCC38 GDC0941 0 1 72 |
| HCC38 | Pictilisib | 1 | 72 | 0.01 | 4329.0 | 4386.3 | 1295.5 | -2.0 | 0.985 | 0.987 | 1.759 | HCC38 GDC0941 0 1 72 |
| HCC38 | Pictilisib | 1 | 72 | 0.032 | 4227.0 | 4386.3 | 1295.5 | -1.49 | 0.958 | 0.964 | 1.759 | HCC38 GDC0941 0 1 72 |
| HCC38 | Pictilisib | 1 | 72 | 0.1 | 4039.3 | 4386.3 | 1295.5 | -1.0 | 0.908 | 0.921 | 1.759 | HCC38 GDC0941 0 1 72 |
| HCC38 | Pictilisib | 1 | 72 | 0.32 | 3613.5 | 4386.3 | 1295.5 | -0.495 | 0.791 | 0.824 | 1.759 | HCC38 GDC0941 0 1 72 |
| HCC38 | Pictilisib | 1 | 72 | 1.0 | 3332.8 | 4386.3 | 1295.5 | 0.0 | 0.711 | 0.760 | 1.759 | HCC38 GDC0941 0 1 72 |
| HCC38 | Pictilisib | 1 | 72 | 3.2 | 2840.0 | 4386.3 | 1295.5 | 0.505 | 0.562 | 0.647 | 1.759 | HCC38 GDC0941 0 1 72 |
| HCC38 | GDC-0980 | 1 | 72 | 0.001 | 4262.8 | 4439.8 | 1295.5 | -3.0 | 0.955 | 0.960 | 1.777 | HCC38 GDC0980 0 1 72 |
| HCC38 | GDC-0980 | 1 | 72 | 0.0032 | 4272.3 | 4439.8 | 1295.5 | -2.49 | 0.957 | 0.962 | 1.777 | HCC38 GDC0980 0 1 72 |
| HCC38 | GDC-0980 | 1 | 72 | 0.01 | 4211.5 | 4439.8 | 1295.5 | -2.0 | 0.941 | 0.949 | 1.777 | HCC38 GDC0980 0 1 72 |
| HCC38 | GDC-0980 | 1 | 72 | 0.032 | 4138.5 | 4439.8 | 1295.5 | -1.49 | 0.922 | 0.932 | 1.777 | HCC38 GDC0980 0 1 72 |
| HCC38 | GDC-0980 | 1 | 72 | 0.1 | 3491.0 | 4439.8 | 1295.5 | -1.0 | 0.747 | 0.786 | 1.777 | HCC38 GDC0980 0 1 72 |
| HCC38 | GDC-0980 | 1 | 72 | 0.32 | 2523.0 | 4439.8 | 1295.5 | -0.495 | 0.455 | 0.568 | 1.777 | HCC38 GDC0980 0 1 72 |
| HCC38 | GDC-0980 | 1 | 72 | 1.0 | 2100.3 | 4439.8 | 1295.5 | 0.0 | 0.312 | 0.473 | 1.777 | HCC38 GDC0980 0 1 72 |
| HCC38 | GDC-0980 | 1 | 72 | 3.2 | 1570.3 | 4439.8 | 1295.5 | 0.505 | 0.114 | 0.354 | 1.777 | HCC38 GDC0980 0 1 72 |
| HCC38 | Omipalisib | 1 | 72 | 0.001 | 3367.5 | 4389.3 | 1295.5 | -3.0 | 0.721 | 0.767 | 1.760 | HCC38 GSK458 0 1 72 |
| HCC38 | Omipalisib | 1 | 72 | 0.0032 | 3811.5 | 4389.3 | 1295.5 | -2.49 | 0.846 | 0.868 | 1.760 | HCC38 GSK458 0 1 72 |
| HCC38 | Omipalisib | 1 | 72 | 0.01 | 3261.8 | 4389.3 | 1295.5 | -2.0 | 0.690 | 0.743 | 1.760 | HCC38 GSK458 0 1 72 |
| HCC38 | Omipalisib | 1 | 72 | 0.032 | 2286.0 | 4389.3 | 1295.5 | -1.49 | 0.381 | 0.521 | 1.760 | HCC38 GSK458 0 1 72 |
| HCC38 | Omipalisib | 1 | 72 | 0.1 | 1835.0 | 4389.3 | 1295.5 | -1.0 | 0.219 | 0.418 | 1.760 | HCC38 GSK458 0 1 72 |
| HCC38 | Omipalisib | 1 | 72 | 0.32 | 1460.0 | 4389.3 | 1295.5 | -0.495 | 0.070 | 0.333 | 1.760 | HCC38 GSK458 0 1 72 |
| HCC38 | Omipalisib | 1 | 72 | 1.0 | 1059.3 | 4389.3 | 1295.5 | 0.0 | -0.108 | 0.241 | 1.760 | HCC38 GSK458 0 1 72 |
| HCC38 | Omipalisib | 1 | 72 | 3.2 | 664.0 | 4389.3 | 1295.5 | 0.505 | -0.316 | 0.151 | 1.760 | HCC38 GSK458 0 1 72 |
| HCC38 | KIN001-244 | 1 | 72 | 0.001 | 4360.0 | 4361.0 | 1295.5 | -3.0 | 1.000 | 1.000 | 1.751 | HCC38 KIN001-244 0 1 72 |
| HCC38 | KIN001-244 | 1 | 72 | 0.0032 | 4232.0 | 4361.0 | 1295.5 | -2.49 | 0.966 | 0.970 | 1.751 | HCC38 KIN001-244 0 1 72 |