Evaluation of the sensitivities of six triple-negative breast cancer (TNBC) cell lines to 23 different PI3K/AKT/mTOR inhibitors or to a MEK inhibitor (trametinib). Dataset 1 of 2: GR values. - Dataset (ID:20364)

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Cell line Drug name Experimental replicate Timepoint Drug concentration Live cell count Average live cell count, DMSO control Average live cell count (time = 0) Log10(drug concentration) GR value Relative cell count (treatment versus DMSO) Cell doublings (DMSO control) Experiment name
BT-549 Torin2 2 72
0.32
 1231.8 4425.3 1249.6
-0.495
 -0.008 0.278 1.824
BT549 Torin2 0 2 72
BT-549 Torin2 2 72
1.0
 939.3 4425.3 1249.6
0.0
 -0.145 0.212 1.824
BT549 Torin2 0 2 72
BT-549 Torin2 2 72
3.2
 684.3 4425.3 1249.6
0.505
 -0.281 0.155 1.824
BT549 Torin2 0 2 72
BT-549 Trametinib 2 72
0.001
 4676.8 4709.3 1249.6
-3.0
 0.993 0.993 1.914
BT549 Trametinib 0 2 72
BT-549 Trametinib 2 72
0.0032
 4611.3 4709.3 1249.6
-2.49
 0.978 0.979 1.914
BT549 Trametinib 0 2 72
BT-549 Trametinib 2 72
0.01
 4390.8 4709.3 1249.6
-2.0
 0.928 0.932 1.914
BT549 Trametinib 0 2 72
BT-549 Trametinib 2 72
0.032
 4013.3 4709.3 1249.6
-1.49
 0.840 0.852 1.914
BT549 Trametinib 0 2 72
BT-549 Trametinib 2 72
0.1
 3756.3 4709.3 1249.6
-1.0
 0.777 0.798 1.914
BT549 Trametinib 0 2 72
BT-549 Trametinib 2 72
0.32
 3304.5 4709.3 1249.6
-0.495
 0.662 0.702 1.914
BT549 Trametinib 0 2 72
BT-549 Trametinib 2 72
1.0
 3131.5 4709.3 1249.6
0.0
 0.616 0.665 1.914
BT549 Trametinib 0 2 72
BT-549 Trametinib 2 72
3.2
 3079.8 4709.3 1249.6
0.505
 0.602 0.654 1.914
BT549 Trametinib 0 2 72
BT-549 WYE-125132 2 72
0.001
 4564.5 4290.8 1249.6
-3.0
 1.070 1.060 1.780
BT549 WYE125132 0 2 72
BT-549 WYE-125132 2 72
0.0032
 4249.3 4290.8 1249.6
-2.49
 0.989 0.990 1.780
BT549 WYE125132 0 2 72
BT-549 WYE-125132 2 72
0.01
 3455.5 4290.8 1249.6
-2.0
 0.771 0.805 1.780
BT549 WYE125132 0 2 72
BT-549 WYE-125132 2 72
0.032
 2619.0 4290.8 1249.6
-1.49
 0.516 0.610 1.780
BT549 WYE125132 0 2 72
BT-549 WYE-125132 2 72
0.1
 1882.0 4290.8 1249.6
-1.0
 0.259 0.439 1.780
BT549 WYE125132 0 2 72
BT-549 WYE-125132 2 72
0.32
 1416.8 4290.8 1249.6
-0.495
 0.073 0.330 1.780
BT549 WYE125132 0 2 72
BT-549 WYE-125132 2 72
1.0
 1530.8 4290.8 1249.6
0.0
 0.121 0.357 1.780
BT549 WYE125132 0 2 72
BT-549 WYE-125132 2 72
3.2
 1429.3 4290.8 1249.6
0.505
 0.078 0.333 1.780
BT549 WYE125132 0 2 72
BT-549 XL147 2 72
0.001
 4503.5 4834.0 1249.6
-3.0
 0.929 0.932 1.952
BT549 XL147 0 2 72
BT-549 XL147 2 72
0.0032
 4838.3 4834.0 1249.6
-2.49
 1.000 1.000 1.952
BT549 XL147 0 2 72
BT-549 XL147 2 72
0.01
 4844.8 4834.0 1249.6
-2.0
 1.000 1.000 1.952
BT549 XL147 0 2 72
BT-549 XL147 2 72
0.032
 5145.5 4834.0 1249.6
-1.49
 1.070 1.060 1.952
BT549 XL147 0 2 72
BT-549 XL147 2 72
0.1
 4898.3 4834.0 1249.6
-1.0
 1.010 1.010 1.952
BT549 XL147 0 2 72
BT-549 XL147 2 72
0.32
 4948.0 4834.0 1249.6
-0.495
 1.020 1.020 1.952
BT549 XL147 0 2 72