Evaluation of the sensitivities of six triple-negative breast cancer (TNBC) cell lines to 23 different PI3K/AKT/mTOR inhibitors or to a MEK inhibitor (trametinib). Dataset 1 of 2: GR values. - Dataset (ID:20364)

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Cell line Drug name Experimental replicate Timepoint Drug concentration Live cell count Average live cell count, DMSO control Average live cell count (time = 0) Log10(drug concentration) GR value Relative cell count (treatment versus DMSO) Cell doublings (DMSO control) Experiment name
BT-549 Sirolimus 2 72
0.1
 3072.8 4441.5 1249.6
-1.0
 0.635 0.692 1.830
BT549 Rapamycin 0 2 72
BT-549 Sirolimus 2 72
0.32
 2981.8 4441.5 1249.6
-0.495
 0.609 0.671 1.830
BT549 Rapamycin 0 2 72
BT-549 Sirolimus 2 72
1.0
 2849.8 4441.5 1249.6
0.0
 0.569 0.642 1.830
BT549 Rapamycin 0 2 72
BT-549 Sirolimus 2 72
3.2
 2883.3 4441.5 1249.6
0.505
 0.579 0.649 1.830
BT549 Rapamycin 0 2 72
BT-549 TGX221 2 72
0.001
 4572.0 4753.0 1249.6
-3.0
 0.960 0.962 1.927
BT549 TGX221 0 2 72
BT-549 TGX221 2 72
0.0032
 4668.0 4753.0 1249.6
-2.49
 0.981 0.982 1.927
BT549 TGX221 0 2 72
BT-549 TGX221 2 72
0.01
 4752.3 4753.0 1249.6
-2.0
 1.000 1.000 1.927
BT549 TGX221 0 2 72
BT-549 TGX221 2 72
0.032
 4846.8 4753.0 1249.6
-1.49
 1.020 1.020 1.927
BT549 TGX221 0 2 72
BT-549 TGX221 2 72
0.1
 4457.5 4753.0 1249.6
-1.0
 0.934 0.938 1.927
BT549 TGX221 0 2 72
BT-549 TGX221 2 72
0.32
 4468.5 4753.0 1249.6
-0.495
 0.937 0.940 1.927
BT549 TGX221 0 2 72
BT-549 TGX221 2 72
1.0
 4200.5 4753.0 1249.6
0.0
 0.876 0.884 1.927
BT549 TGX221 0 2 72
BT-549 TGX221 2 72
3.2
 3763.3 4753.0 1249.6
0.505
 0.772 0.792 1.927
BT549 TGX221 0 2 72
BT-549 Torin1 2 72
0.001
 4670.8 4603.3 1249.6
-3.0
 1.020 1.010 1.881
BT549 Torin1 0 2 72
BT-549 Torin1 2 72
0.0032
 3833.8 4603.3 1249.6
-2.49
 0.815 0.833 1.881
BT549 Torin1 0 2 72
BT-549 Torin1 2 72
0.01
 3050.5 4603.3 1249.6
-2.0
 0.607 0.663 1.881
BT549 Torin1 0 2 72
BT-549 Torin1 2 72
0.032
 2213.0 4603.3 1249.6
-1.49
 0.355 0.481 1.881
BT549 Torin1 0 2 72
BT-549 Torin1 2 72
0.1
 1714.5 4603.3 1249.6
-1.0
 0.183 0.372 1.881
BT549 Torin1 0 2 72
BT-549 Torin1 2 72
0.32
 1495.8 4603.3 1249.6
-0.495
 0.100 0.325 1.881
BT549 Torin1 0 2 72
BT-549 Torin1 2 72
1.0
 1461.5 4603.3 1249.6
0.0
 0.087 0.317 1.881
BT549 Torin1 0 2 72
BT-549 Torin1 2 72
3.2
 1320.5 4603.3 1249.6
0.505
 0.030 0.287 1.881
BT549 Torin1 0 2 72
BT-549 Torin2 2 72
0.001
 4196.8 4425.3 1249.6
-3.0
 0.943 0.948 1.824
BT549 Torin2 0 2 72
BT-549 Torin2 2 72
0.0032
 3113.0 4425.3 1249.6
-2.49
 0.649 0.703 1.824
BT549 Torin2 0 2 72
BT-549 Torin2 2 72
0.01
 2417.3 4425.3 1249.6
-2.0
 0.436 0.546 1.824
BT549 Torin2 0 2 72
BT-549 Torin2 2 72
0.032
 1900.8 4425.3 1249.6
-1.49
 0.259 0.430 1.824
BT549 Torin2 0 2 72
BT-549 Torin2 2 72
0.1
 1508.0 4425.3 1249.6
-1.0
 0.109 0.341 1.824
BT549 Torin2 0 2 72