Evaluation of the sensitivities of six triple-negative breast cancer (TNBC) cell lines to 23 different PI3K/AKT/mTOR inhibitors or to a MEK inhibitor (trametinib). Dataset 1 of 2: GR values. - Dataset (ID:20364)

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Cell line Drug name Experimental replicate Timepoint Drug concentration Live cell count Average live cell count, DMSO control Average live cell count (time = 0) Log10(drug concentration) GR value Relative cell count (treatment versus DMSO) Cell doublings (DMSO control) Experiment name
Hs 578T Torin2 2 72
0.0032
 2511.5 3604.3 624.7
-2.49
 0.734 0.697 2.528
Hs578T Torin2 2
Hs 578T Torin2 2 72
0.01
 1713.5 3604.3 624.7
-2.0
 0.490 0.475 2.528
Hs578T Torin2 2
Hs 578T Torin2 2 72
0.032
 1265.0 3604.3 624.7
-1.49
 0.322 0.351 2.528
Hs578T Torin2 2
Hs 578T Torin2 2 72
0.1
 937.8 3604.3 624.7
-1.0
 0.174 0.260 2.528
Hs578T Torin2 2
Hs 578T Torin2 2 72
0.32
 563.0 3604.3 624.7
-0.495
 -0.040 0.156 2.528
Hs578T Torin2 2
Hs 578T Torin2 2 72
1.0
 212.3 3604.3 624.7
0.0
 -0.347 0.059 2.528
Hs578T Torin2 2
Hs 578T Torin2 2 72
3.2
 127.3 3604.3 624.7
0.505
 -0.467 0.035 2.528
Hs578T Torin2 2
Hs 578T Trametinib 2 72
0.001
 2454.8 3491.8 624.7
-3.0
 0.735 0.703 2.483
Hs578T Trametinib 2
Hs 578T Trametinib 2 72
0.0032
 2014.5 3491.8 624.7
-2.49
 0.603 0.577 2.483
Hs578T Trametinib 2
Hs 578T Trametinib 2 72
0.01
 1529.3 3491.8 624.7
-2.0
 0.434 0.438 2.483
Hs578T Trametinib 2
Hs 578T Trametinib 2 72
0.032
 1205.8 3491.8 624.7
-1.49
 0.303 0.345 2.483
Hs578T Trametinib 2
Hs 578T Trametinib 2 72
0.1
 935.8 3491.8 624.7
-1.0
 0.177 0.268 2.483
Hs578T Trametinib 2
Hs 578T Trametinib 2 72
0.32
 783.0 3491.8 624.7
-0.495
 0.095 0.224 2.483
Hs578T Trametinib 2
Hs 578T Trametinib 2 72
1.0
 753.3 3491.8 624.7
0.0
 0.078 0.216 2.483
Hs578T Trametinib 2
Hs 578T Trametinib 2 72
3.2
 745.8 3491.8 624.7
0.505
 0.074 0.214 2.483
Hs578T Trametinib 2
Hs 578T WYE-125132 2 72
0.001
 3450.3 3642.3 624.7
-3.0
 0.958 0.947 2.544
Hs578T WYE125132 2
Hs 578T WYE-125132 2 72
0.0032
 3205.3 3642.3 624.7
-2.49
 0.902 0.880 2.544
Hs578T WYE125132 2
Hs 578T WYE-125132 2 72
0.01
 2723.8 3642.3 624.7
-2.0
 0.784 0.748 2.544
Hs578T WYE125132 2
Hs 578T WYE-125132 2 72
0.032
 1876.5 3642.3 624.7
-1.49
 0.541 0.515 2.544
Hs578T WYE125132 2
Hs 578T WYE-125132 2 72
0.1
 1232.5 3642.3 624.7
-1.0
 0.306 0.338 2.544
Hs578T WYE125132 2
Hs 578T WYE-125132 2 72
0.32
 1007.0 3642.3 624.7
-0.495
 0.206 0.276 2.544
Hs578T WYE125132 2
Hs 578T WYE-125132 2 72
1.0
 936.5 3642.3 624.7
0.0
 0.173 0.257 2.544
Hs578T WYE125132 2
Hs 578T WYE-125132 2 72
3.2
 896.3 3642.3 624.7
0.505
 0.152 0.246 2.544
Hs578T WYE125132 2
Hs 578T XL147 2 72
0.001
 3450.8 3556.8 624.7
-3.0
 0.976 0.970 2.509
Hs578T XL147 2
Hs 578T XL147 2 72
0.0032
 3536.3 3556.8 624.7
-2.49
 0.995 0.994 2.509
Hs578T XL147 2