Evaluation of the sensitivities of six triple-negative breast cancer (TNBC) cell lines to 23 different PI3K/AKT/mTOR inhibitors or to a MEK inhibitor (trametinib). Dataset 1 of 2: GR values. - Dataset (ID:20364)
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| Cell line | Drug name | Experimental replicate | Timepoint | Drug concentration | Live cell count | Average live cell count, DMSO control | Average live cell count (time = 0) | Log10(drug concentration) | GR value | Relative cell count (treatment versus DMSO) | Cell doublings (DMSO control) | Experiment name |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Hs 578T | AZD8055 | 1 | 72 | 0.1 | 1406.0 | 3514.5 | 873.1 | -1.0 | 0.268 | 0.400 | 2.009 | Hs578T AZD8055 1 |
| Hs 578T | AZD8055 | 1 | 72 | 0.32 | 1141.3 | 3514.5 | 873.1 | -0.495 | 0.143 | 0.325 | 2.009 | Hs578T AZD8055 1 |
| Hs 578T | AZD8055 | 1 | 72 | 1.0 | 1056.5 | 3514.5 | 873.1 | 0.0 | 0.100 | 0.301 | 2.009 | Hs578T AZD8055 1 |
| Hs 578T | AZD8055 | 1 | 72 | 3.2 | 1005.8 | 3514.5 | 873.1 | 0.505 | 0.073 | 0.286 | 2.009 | Hs578T AZD8055 1 |
| Hs 578T | Dactolisib | 1 | 72 | 0.001 | 3257.3 | 3608.8 | 873.1 | -3.0 | 0.902 | 0.903 | 2.047 | Hs578T BEZ235 1 |
| Hs 578T | Dactolisib | 1 | 72 | 0.0032 | 2819.5 | 3608.8 | 873.1 | -2.49 | 0.773 | 0.781 | 2.047 | Hs578T BEZ235 1 |
| Hs 578T | Dactolisib | 1 | 72 | 0.01 | 1815.0 | 3608.8 | 873.1 | -2.0 | 0.430 | 0.503 | 2.047 | Hs578T BEZ235 1 |
| Hs 578T | Dactolisib | 1 | 72 | 0.032 | 1346.5 | 3608.8 | 873.1 | -1.49 | 0.236 | 0.373 | 2.047 | Hs578T BEZ235 1 |
| Hs 578T | Dactolisib | 1 | 72 | 0.1 | 1208.5 | 3608.8 | 873.1 | -1.0 | 0.172 | 0.335 | 2.047 | Hs578T BEZ235 1 |
| Hs 578T | Dactolisib | 1 | 72 | 0.32 | 1095.0 | 3608.8 | 873.1 | -0.495 | 0.117 | 0.303 | 2.047 | Hs578T BEZ235 1 |
| Hs 578T | Dactolisib | 1 | 72 | 1.0 | 899.5 | 3608.8 | 873.1 | 0.0 | 0.015 | 0.249 | 2.047 | Hs578T BEZ235 1 |
| Hs 578T | Dactolisib | 1 | 72 | 3.2 | 768.3 | 3608.8 | 873.1 | 0.505 | -0.061 | 0.213 | 2.047 | Hs578T BEZ235 1 |
| Hs 578T | Buparlisib | 1 | 72 | 0.001 | 3598.5 | 3651.8 | 873.1 | -3.0 | 0.986 | 0.985 | 2.064 | Hs578T BKM120 1 |
| Hs 578T | Buparlisib | 1 | 72 | 0.0032 | 3416.3 | 3651.8 | 873.1 | -2.49 | 0.936 | 0.936 | 2.064 | Hs578T BKM120 1 |
| Hs 578T | Buparlisib | 1 | 72 | 0.01 | 3506.0 | 3651.8 | 873.1 | -2.0 | 0.961 | 0.960 | 2.064 | Hs578T BKM120 1 |
| Hs 578T | Buparlisib | 1 | 72 | 0.032 | 3520.3 | 3651.8 | 873.1 | -1.49 | 0.965 | 0.964 | 2.064 | Hs578T BKM120 1 |
| Hs 578T | Buparlisib | 1 | 72 | 0.1 | 3235.0 | 3651.8 | 873.1 | -1.0 | 0.886 | 0.886 | 2.064 | Hs578T BKM120 1 |
| Hs 578T | Buparlisib | 1 | 72 | 0.32 | 2526.8 | 3651.8 | 873.1 | -0.495 | 0.673 | 0.692 | 2.064 | Hs578T BKM120 1 |
| Hs 578T | Buparlisib | 1 | 72 | 1.0 | 1329.3 | 3651.8 | 873.1 | 0.0 | 0.226 | 0.364 | 2.064 | Hs578T BKM120 1 |
| Hs 578T | Buparlisib | 1 | 72 | 3.2 | 146.5 | 3651.8 | 873.1 | 0.505 | -0.579 | 0.040 | 2.064 | Hs578T BKM120 1 |
| Hs 578T | BX-912 | 1 | 72 | 0.001 | 3608.5 | 3493.8 | 873.1 | -3.0 | 1.030 | 1.030 | 2.001 | Hs578T BX912 1 |
| Hs 578T | BX-912 | 1 | 72 | 0.0032 | 3647.8 | 3493.8 | 873.1 | -2.49 | 1.040 | 1.040 | 2.001 | Hs578T BX912 1 |
| Hs 578T | BX-912 | 1 | 72 | 0.01 | 3559.8 | 3493.8 | 873.1 | -2.0 | 1.020 | 1.020 | 2.001 | Hs578T BX912 1 |
| Hs 578T | BX-912 | 1 | 72 | 0.032 | 3582.3 | 3493.8 | 873.1 | -1.49 | 1.030 | 1.030 | 2.001 | Hs578T BX912 1 |
| Hs 578T | BX-912 | 1 | 72 | 0.1 | 3418.5 | 3493.8 | 873.1 | -1.0 | 0.978 | 0.978 | 2.001 | Hs578T BX912 1 |