Breast Cancer Profiling Project, Drug Sensitivity phase II: Fixed-cell GR measures of 33 breast cell lines and PDX lines to 16 small molecule perturbagens from library plate II. Dataset 2 of 2: Calculated dose response metrics - Dataset (ID:20355)
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| Cell | Small Molecule | GR50 | GRmax | GR_AOC | GEC50 | GRinf | GR Hill Coefficient | GR r2 | pval_GR |
|---|---|---|---|---|---|---|---|---|---|
| SUM159PT | MK 1775 | 2.079002463 | -0.1602 | 0.2571 | 9.8880 | -1.0000 | 0.7045 | 0.8868 | 1.5e-12 |
| SUM159PT | AZD2014 | 0.175359057 | 0.0970 | 0.4747 | 4.2801 | -0.5797 | 0.2409 | 0.9735 | 1.11e-16 |
| SUM159PT | AZD5363 | 9.699048275 | 0.4042 | 0.1679 | 240.6645 | -1.0000 | 0.3421 | 0.9046 | 1.77e-13 |
| SUM159PT | AZD6738 | 10.0174126 | 0.4273 | -0.0067 | 12.5628 | -1.0000 | 4.8522 | 0.9120 | 6.41e-14 |
| SUM159PT | BMS-265246 | 0.172330399 | 0.2597 | 0.4599 | 0.0830 | 0.1038 | 0.3184 | 0.9301 | 3.55e-15 |
| SUM159PT | Ulixertinib | 1.943050817 | 0.1333 | 0.2476 | 22.3099 | -1.0000 | 0.4501 | 0.9582 | 1.11e-16 |
| SUM159PT | Alvocidib | 0.135046848 | -0.0857 | 0.2341 | 0.1695 | -0.1659 | 1.2608 | 0.9830 | 1.11e-16 |
| SUM159PT | GSK2334470 | 25.92061031 | 0.5981 | 0.1174 | 315.7369 | -1.0000 | 0.4395 | 0.8088 | 1.04e-09 |
| SUM159PT | Ribociclib | 9.362543456 | 0.3950 | 0.2403 | 1000.0000 | -0.9311 | 0.2251 | 0.8497 | 5.16e-11 |
| SUM159PT | LY3023414 | 0.001300375 | 0.0271 | 0.7252 | 0.0029 | -0.0905 | 0.2088 | 0.9598 | 1.11e-16 |
| SUM159PT | RO-3306 | 7.498110755 | 0.1030 | 0.0581 | 11.0876 | -1.0000 | 2.8085 | 0.9796 | 1.11e-16 |
| SUM159PT | Rucaparib | 1.81722e+11 | 0.7797 | 0.0896 | 999.9789 | 0.4809 | 0.1718 | 0.3608 | 0.003721786 |
| SUM159PT | Senexin B | inf | 0.9016 | 0.0793 | 0.0000 | 0.9165 | 0.0100 | 0.0000 | 0.292587245 |
| SUM159PT | SHP099 | 3294.604776 | 0.8118 | 0.0447 | 1000.0000 | 0.1710 | 0.3511 | 0.3261 | 0.007206359 |
| SUM159PT | THZ1 | 0.365558748 | -0.1398 | 0.1554 | 0.8540 | -1.0000 | 1.2947 | 0.9765 | 1.11e-16 |
| SUM159PT | THZ531 | 1.158729591 | 0.6103 | 0.0475 | 1.7617 | -1.0000 | 2.6222 | 0.8700 | 8.37e-12 |
| T47D | MK 1775 | 5.03699179 | 0.0963 | 0.1055 | 14.4307 | -1.0000 | 1.0438 | 0.8167 | 6.18e-10 |
| T47D | AZD2014 | 3.57e-05 | -0.0845 | 0.9793 | 0.0001 | -0.1251 | 0.2870 | 0.8093 | 1.01e-09 |
| T47D | AZD5363 | 0.013673243 | 0.1402 | 0.6141 | 0.0075 | 0.1295 | 0.5033 | 0.9281 | 5.11e-15 |
| T47D | AZD6738 | inf | 0.6619 | -0.2131 | 0.0000 | 1.0000 | 0.0100 | -0.9822 | 0.211726496 |
| T47D | BMS-265246 | 0.014946978 | -0.0154 | 0.6421 | 2.6347 | -0.7862 | 0.1827 | 0.8936 | 6.85e-13 |
| T47D | Ulixertinib | 3.528421043 | 0.1952 | 0.2003 | 28.8265 | -1.0000 | 0.5230 | 0.8600 | 2.12e-11 |
| T47D | Alvocidib | 0.115068759 | -0.1548 | 0.2473 | 0.2275 | -0.4346 | 0.9177 | 0.9066 | 1.35e-13 |
| T47D | GSK2334470 | 0.455522213 | 0.1531 | 0.3958 | 0.9464 | -0.1424 | 0.3428 | 0.9385 | 6.66e-16 |
| T47D | Ribociclib | -inf | 0.0709 |