Breast Cancer Profiling Project, Drug Sensitivity phase II: Fixed-cell GR measures of 33 breast cell lines and PDX lines to 16 small molecule perturbagens from library plate II. Dataset 2 of 2: Calculated dose response metrics - Dataset (ID:20355)
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| Cell | Small Molecule | GR50 | GRmax | GR_AOC | GEC50 | GRinf | GR Hill Coefficient | GR r2 | pval_GR |
|---|---|---|---|---|---|---|---|---|---|
| SUM1315MO2 | GSK2334470 | 3.600228452 | 0.4232 | 0.3147 | 3.1371 | 0.0175 | 0.2587 | 0.5781 | 2.07e-05 |
| SUM1315MO2 | Ribociclib | 2.417104164 | 0.4065 | 0.3624 | 0.0997 | 0.2788 | 0.2557 | 0.5827 | 1.8e-05 |
| SUM1315MO2 | LY3023414 | 0.016412717 | -0.2854 | 0.6641 | 4.0058 | -1.0000 | 0.1998 | 0.8425 | 9.21e-11 |
| SUM1315MO2 | RO-3306 | 2.725021263 | -0.1710 | 0.2025 | 3.6560 | -0.3370 | 1.7529 | 0.8824 | 2.39e-12 |
| SUM1315MO2 | Rucaparib | 17.80541463 | 0.2942 | 0.3317 | 1000.0000 | -0.3226 | 0.1236 | 0.3203 | 0.008018079 |
| SUM1315MO2 | Senexin B | inf | 0.7371 | 0.2113 | 0.5888 | 0.5399 | 0.2353 | 0.2333 | 0.036109414 |
| SUM1315MO2 | SHP099 | 22.32790504 | 0.4783 | 0.1197 | 419.3194 | -1.0000 | 0.3746 | 0.3197 | 0.008107411 |
| SUM1315MO2 | THZ1 | 0.21954393 | -0.6621 | 0.1975 | 0.4131 | -1.0000 | 1.7380 | 0.8819 | 2.54e-12 |
| SUM1315MO2 | THZ531 | 0.384907936 | -0.5158 | 0.1804 | 0.6323 | -1.0000 | 2.2135 | 0.9315 | 2.78e-15 |
| SUM149PT | MK 1775 | 0.07431046 | -0.3915 | 0.6115 | 1.7986 | -1.0000 | 0.3448 | 0.9622 | 1.11e-16 |
| SUM149PT | AZD2014 | 1.870533874 | 0.3557 | 0.3916 | 1000.0000 | -0.6285 | 0.1296 | 0.8137 | 7.57e-10 |
| SUM149PT | AZD5363 | 6.721919624 | 0.3022 | 0.1227 | 30.2610 | -1.0000 | 0.7302 | 0.8514 | 4.46e-11 |
| SUM149PT | AZD6738 | 3.915511205 | -0.2335 | 0.1272 | 7.7322 | -1.0000 | 1.6146 | 0.9698 | 1.11e-16 |
| SUM149PT | BMS-265246 | 0.016950371 | 0.0738 | 0.6317 | 0.0171 | -0.0015 | 0.3767 | 0.9526 | 1.11e-16 |
| SUM149PT | Ulixertinib | 2.037761408 | 0.1734 | 0.2350 | 4.8956 | -0.2916 | 0.5241 | 0.9161 | 3.52e-14 |
| SUM149PT | Alvocidib | 0.194050461 | -0.4382 | 0.2360 | 0.3478 | -0.7138 | 1.5198 | 0.9775 | 1.11e-16 |
| SUM149PT | GSK2334470 | 25.76380861 | 0.6531 | 0.0406 | 118.2600 | -1.0000 | 0.7209 | 0.5628 | 3.22e-05 |
| SUM149PT | Ribociclib | 229.6984296 | 0.5649 | 0.1855 | 1.4808 | 0.4031 | 0.3252 | 0.8653 | 1.31e-11 |
| SUM149PT | LY3023414 | 1.560308156 | -0.0238 | 0.2943 | 18.4015 | -1.0000 | 0.4452 | 0.8188 | 5.32e-10 |
| SUM149PT | RO-3306 | 4.932869662 | -0.1636 | 0.1067 | 8.7826 | -1.0000 | 1.9045 | 0.9726 | 1.11e-16 |
| SUM149PT | Rucaparib | 66.68976855 | 0.5687 | 0.2055 | 1000.0000 | -0.3605 | 0.2005 | 0.6540 | 1.73e-06 |
| SUM149PT | Senexin B | inf | 0.5896 | 0.1339 | 0.0126 | 0.8101 | 1.1518 | 0.4355 | 0.000786678 |
| SUM149PT | SHP099 | 31.82140091 | 0.7648 | -0.0244 | 70.8992 | -0.9990 | 1.3705 | 0.2286 | 0.038994512 |
| SUM149PT | THZ1 | 0.048963473 | -0.4879 | 0.4000 | 0.0794 | -0.4676 | 1.3644 | 0.9885 | 1.11e-16 |
| SUM149PT | THZ531 | 0.351886206 | -0.4909 | 0.1494 | 0.5549 | -0.8336 | 2.1536 | 0.9830 | 1.11e-16 |