Breast Cancer Profiling Project, Drug Sensitivity phase II: Fixed-cell GR measures of 33 breast cell lines and PDX lines to 16 small molecule perturbagens from library plate II. Dataset 2 of 2: Calculated dose response metrics - Dataset (ID:20355)
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| Cell | Small Molecule | GR50 | GRmax | GR_AOC | GEC50 | GRinf | GR Hill Coefficient | GR r2 | pval_GR |
|---|---|---|---|---|---|---|---|---|---|
| SK-BR-3 | Ribociclib | 7.336808762 | 0.5685 | 0.3263 | 0.0430 | 0.4151 | 0.3450 | 0.5408 | 5.95e-05 |
| HCC1143 | Ribociclib | 3.643695147 | 0.3009 | 0.2535 | 264.9902 | -1.0000 | 0.2563 | 0.8300 | 2.41e-10 |
| CAL-85-1 | Ribociclib | inf | 0.9479 | 0.1502 | 0.0000 | 0.8929 | 0.0100 | 0.0000 | 1.0 |
| MDA-MB-436 | Ribociclib | inf | 0.9493 | -0.0090 | 0.0000 | 1.0000 | 0.0100 | -0.0149 | 0.928505437 |
| MDA-MB-231 | Ribociclib | 0.882152688922 | 0.2071 | 0.3624 | 164.4949 | -1.0000 | 0.2101 | 0.8981 | 4.00901534192e-13 |
| HCC1500 | Ribociclib | inf | 1.0336 | 0.4512 | 0.0000 | 0.5131 | 0.0100 | 0.0000 | 1.0 |
| MDA-MB-453 | Ribociclib | 0.036110625 | 0.1975 | 0.5328 | 0.0251 | 0.0538 | 0.3126 | 0.8276 | 2.86e-10 |
| HCC1937 | Ribociclib | inf | 0.9905 | -0.0141 | 0.0000 | 0.9898 | 0.0100 | 0.0000 | 1.0 |
| HCC1428 | Ribociclib | #NAME? | -0.3849 | 0.7838 | 0.0000 | 0.2963 | 0.0100 | 0.0000 | 0.210923138 |
| MCF 10A | Ribociclib | 21.11238563 | 0.4876 | 0.1616 | 1000.0000 | -1.0000 | 0.2848 | 0.8863 | 1.58e-12 |
| HCC1395 | Ribociclib | 3.698589599 | 0.3894 | 0.3243 | 1000.0000 | -0.7936 | 0.1697 | 0.6529 | 1.8e-06 |
| T47D | Ribociclib | -inf | 0.0709 | ||||||
| Hs 578T | Ribociclib | 2.691890869 | 0.3645 | 0.3425 | 1000.0000 | -0.7904 | 0.1602 | 0.9056 | 1.53e-13 |
| MDA-MB-134-VI | Ribociclib | -inf | 0.2592 | 0.7185 | 0.0000 | 0.3047 | 0.0100 | 0.0000 | 0.311703691 |
| MDA-MB-157 | Ribociclib | inf | 0.5908 | 0.0808 | 0.0790 | 0.8320 | 5.0000 | 0.2263 | 0.040460682 |
| SUM149PT | Ribociclib | 229.6984296 | 0.5649 | 0.1855 | 1.4808 | 0.4031 | 0.3252 | 0.8653 | 1.31e-11 |
| CAMA-1 | Ribociclib | 0.009012358 | 0.1601 | 0.6510 | 0.0058 | 0.0871 | 0.4330 | 0.8208 | 4.65e-10 |
| SUM1315MO2 | Ribociclib | 2.417104164 | 0.4065 | 0.3624 | 0.0997 | 0.2788 | 0.2557 | 0.5827 | 1.8e-05 |
| HCC1954 | Ribociclib | 66.3393103634 | 0.5260 | 0.3269 | 43.1744 | 0.0265 | 0.1268 | 0.4412 | 0.000692485845485 |
| HME1 | Ribociclib | 1.226062584 | 0.2866 | 0.3557 | 348.8011 | -1.0000 | 0.1944 | 0.9022 | 2.38e-13 |
| BT-549 | Ribociclib | inf | 0.9258 | 0.0097 | 0.0000 | 0.9885 | 0.0100 | 0.0000 | 0.489440623384 |
| HCC70 | Ribociclib | inf | 1.0564 | -0.0040 | 0.0000 | 1.0000 | 0.0100 | -0.1699 | 1.0 |
| SUM159PT | Ribociclib | 9.362543456 | 0.3950 | 0.2403 | 1000.0000 | -0.9311 | 0.2251 | 0.8497 | 5.16e-11 |
| AU565 | Ribociclib | 0.595293001 | 0.2313 | 0.4319 | 179.3835 | -0.8827 | 0.1782 | 0.7890 | 3.57e-09 |
| MDA-MB-468 | Ribociclib | inf | 0.7972 | 0.0091 | 0.0000 | 0.9779 | 0.0100 | 0.0000 | 1.0 |