Breast Cancer Profiling Project, Drug Sensitivity phase II: Fixed-cell GR measures of 33 breast cell lines and PDX lines to 16 small molecule perturbagens from library plate II. Dataset 2 of 2: Calculated dose response metrics - Dataset (ID:20355)
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| Cell | Small Molecule | GR50 | GRmax | GR_AOC | GEC50 | GRinf | GR Hill Coefficient | GR r2 | pval_GR |
|---|---|---|---|---|---|---|---|---|---|
| Hs 578T | MK 1775 | 0.014507078 | -0.3462 | 0.7648 | 0.0762 | -0.4564 | 0.3909 | 0.9740 | 1.11e-16 |
| HME1 | MK 1775 | 0.311734421 | -0.1519 | 0.4391 | 7.7966 | -1.0000 | 0.3413 | 0.9413 | 4.44e-16 |
| MCF 10A | MK 1775 | 4.928502071 | -0.1207 | 0.1367 | 9.4221 | -1.0000 | 1.6953 | 0.9500 | 1.11e-16 |
| MCF7 | MK 1775 | -inf | -0.1007 | ||||||
| MDA-MB-134-VI | MK 1775 | 0.087205685 | -0.3434 | 0.5624 | 3.0209 | -1.0000 | 0.3099 | 0.7289 | 8.21e-08 |
| MDA-MB-157 | MK 1775 | -inf | -0.8758 | ||||||
| MDA-MB-361 | MK 1775 | 0.005155215 | -0.3351 | 0.8878 | 0.0200 | -0.3972 | 0.4315 | 0.8532 | 3.83e-11 |
| MDA-MB-436 | MK 1775 | 0.189831078 | -0.2473 | 0.4933 | 6.7449 | -1.0000 | 0.3077 | 0.8316 | 2.13e-10 |
| MDA-MB-453 | MK 1775 | 0.103540362 | -0.1845 | 0.5656 | 0.2626 | -0.3748 | 0.6010 | 0.9620 | 1.11e-16 |
| MDA-MB-468 | MK 1775 | 0.262235497 | -0.5155 | 0.4993 | 3.2089 | -1.0000 | 0.4387 | 0.8844 | 1.93e-12 |
| SK-BR-3 | MK 1775 | 0.230887652 | -0.6053 | 0.5073 | 2.0221 | -1.0000 | 0.5063 | 0.8951 | 5.72e-13 |
| SUM1315MO2 | MK 1775 | 0.00109721 | -0.6828 | 0.9928 | 0.0075 | -0.4794 | 0.3502 | 0.6449 | 2.4e-06 |
| SUM149PT | MK 1775 | 0.07431046 | -0.3915 | 0.6115 | 1.7986 | -1.0000 | 0.3448 | 0.9622 | 1.11e-16 |
| SUM159PT | MK 1775 | 2.079002463 | -0.1602 | 0.2571 | 9.8880 | -1.0000 | 0.7045 | 0.8868 | 1.5e-12 |
| T47D | MK 1775 | 5.03699179 | 0.0963 | 0.1055 | 14.4307 | -1.0000 | 1.0438 | 0.8167 | 6.18e-10 |
| BT-20 | MK 1775 | 1.80498033053 | -0.6583 | 0.2015 | 4.1869 | -1.0000 | 1.3057 | 0.9322 | 2.44249065418e-15 |
| BT-549 | MK 1775 | 0.285141860039 | -0.4630 | 0.4365 | 2.2824 | -1.0000 | 0.5282 | 0.9608 | 1.11022302463e-16 |
| HCC1806 | MK 1775 | 0.0128166062504 | -0.4617 | 0.8151 | 0.0380 | -0.4095 | 0.5503 | 0.9684 | 1.11022302463e-16 |
| HCC1954 | MK 1775 | 1.30961385046 | -0.4209 | 0.3053 | 5.8191 | -1.0000 | 0.7366 | 0.8046 | 1.37290245839e-09 |
| HCC70 | MK 1775 | 0.000494343213706 | -0.7213 | 1.1390 | 0.0113 | -0.7848 | 0.3020 | 0.9292 | 4.21884749358e-15 |
| MCF 10A | MK 1775 | 6.09709750724 | 0.0219 | 0.0882 | 10.8200 | -1.0000 | 1.9153 | 0.9738 | 1.11022302463e-16 |
| MDA-MB-231 | MK 1775 | 0.0495006301623 | -0.3377 | 0.6074 | 0.0928 | -0.2732 | 0.6936 | 0.9722 | 1.11022302463e-16 |
| MCF 10A | Ribociclib | 11.7857143478 | 0.4369 | 0.2382 | 1000.0000 | -0.8407 | 0.2221 | 0.8769 | 4.26025881239e-12 |
| MDA-MB-361 | Ribociclib | 0.00037253 | 0.1935 | 0.7764 | 0.0005 | -0.0324 | 0.2292 | 0.4761 | 0.000309356 |
| HCC1806 | Ribociclib | 168.232015049 | 0.6251 | 0.1419 | 317.3038 | -0.1285 | 0.3606 | 0.3213 | 0.00787309835959 |