Breast Cancer Profiling Project, Drug Sensitivity phase II: Fixed-cell GR measures of 33 breast cell lines and PDX lines to 16 small molecule perturbagens from library plate II. Dataset 2 of 2: Calculated dose response metrics - Dataset (ID:20355)
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| Cell | Small Molecule | GR50 | GRmax | GR_AOC | GEC50 | GRinf | GR Hill Coefficient | GR r2 | pval_GR |
|---|---|---|---|---|---|---|---|---|---|
| SK-BR-3 | LY3023414 | 0.002156645 | -0.5571 | 0.8238 | 0.7182 | -1.0000 | 0.1891 | 0.7978 | 2.1e-09 |
| HCC1428 | AZD2014 | 2.19e-05 | -0.5555 | 1.2048 | 0.0005 | -0.5838 | 0.2503 | 0.4940 | 0.000200146 |
| AU565 | Alvocidib | 0.087632457 | -0.5502 | 0.3751 | 0.2006 | -0.8064 | 1.1595 | 0.9601 | 1.11e-16 |
| HCC70 | AZD6738 | 1.73555477677 | -0.5435 | 0.2705 | 4.4527 | -1.0000 | 1.1660 | 0.9336 | 1.88737914186e-15 |
| HCC38 | THZ1 | 0.02382594 | -0.5420 | 0.5167 | 0.0405 | -0.4828 | 1.2756 | 0.9829 | 1.11e-16 |
| MDA-MB-361 | THZ531 | 0.027601073 | -0.5305 | 0.6318 | 0.0328 | -0.6914 | 5.0000 | 0.9478 | 1.11e-16 |
| CAL-85-1 | MK 1775 | 0.182874423 | -0.5298 | 0.5409 | 3.0854 | -1.0000 | 0.3888 | 0.7205 | 1.2e-07 |
| HCC1954 | THZ1 | 0.0965224052209 | -0.5246 | 0.2985 | 0.1858 | -0.6687 | 1.2967 | 0.9764 | 1.11022302463e-16 |
| SUM1315MO2 | THZ531 | 0.384907936 | -0.5158 | 0.1804 | 0.6323 | -1.0000 | 2.2135 | 0.9315 | 2.78e-15 |
| MDA-MB-468 | MK 1775 | 0.262235497 | -0.5155 | 0.4993 | 3.2089 | -1.0000 | 0.4387 | 0.8844 | 1.93e-12 |
| CAMA-1 | THZ1 | 0.032222346 | -0.5114 | 0.4685 | 0.2234 | -1.0000 | 0.5674 | 0.9266 | 6.55e-15 |
| HCC1954 | Alvocidib | 0.122877922248 | -0.5082 | 0.3279 | 0.3492 | -1.0000 | 1.0520 | 0.9645 | 1.11022302463e-16 |
| CAL-85-1 | THZ1 | 0.007789492 | -0.5032 | 0.6841 | 0.0452 | -0.7693 | 0.5298 | 0.8779 | 3.85e-12 |
| CAMA-1 | LY3023414 | 4.27e-05 | -0.5001 | 0.9375 | 0.0004 | -0.2985 | 0.2143 | 0.5057 | 0.00014946 |
| AU565 | THZ531 | 0.054699066 | -0.4980 | 0.4261 | 0.0769 | -0.4380 | 1.8479 | 0.9799 | 1.11e-16 |
| MDA-MB-361 | Alvocidib | 0.089713792 | -0.4956 | 0.4193 | 0.3494 | -1.0000 | 0.8080 | 0.8065 | 1.21e-09 |
| SUM149PT | THZ531 | 0.351886206 | -0.4909 | 0.1494 | 0.5549 | -0.8336 | 2.1536 | 0.9830 | 1.11e-16 |
| SUM149PT | THZ1 | 0.048963473 | -0.4879 | 0.4000 | 0.0794 | -0.4676 | 1.3644 | 0.9885 | 1.11e-16 |
| HCC1806 | Alvocidib | 0.165238718298 | -0.4850 | 0.2588 | 0.4377 | -1.0000 | 1.1279 | 0.9859 | 1.11022302463e-16 |
| MDA-MB-231 | THZ1 | 0.0637722395519 | -0.4824 | 0.3383 | 0.1459 | -0.6653 | 1.0222 | 0.9846 | 1.11022302463e-16 |
| MCF 10A | Alvocidib | 0.099467899 | -0.4802 | 0.3475 | 0.1398 | -0.5288 | 2.1178 | 0.9920 | 1.11e-16 |
| AU565 | LY3023414 | 0.003983539 | -0.4704 | 0.7921 | 0.8999 | -1.0000 | 0.2027 | 0.8707 | 7.87e-12 |
| BT-549 | MK 1775 | 0.285141860039 | -0.4630 | 0.4365 | 2.2824 | -1.0000 | 0.5282 | 0.9608 | 1.11022302463e-16 |
| MDA-MB-134-VI | Alvocidib | -inf | -0.4621 | ||||||
| HCC1806 | MK 1775 | 0.0128166062504 | -0.4617 | 0.8151 | 0.0380 | -0.4095 | 0.5503 | 0.9684 | 1.11022302463e-16 |