Breast Cancer Profiling Project, Drug Sensitivity phase II: Fixed-cell GR measures of 33 breast cell lines and PDX lines to 16 small molecule perturbagens from library plate II. Dataset 2 of 2: Calculated dose response metrics - Dataset (ID:20355)
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| Cell | Small Molecule | GR50 | GRmax | GR_AOC | GEC50 | GRinf | GR Hill Coefficient | GR r2 | pval_GR |
|---|---|---|---|---|---|---|---|---|---|
| HCC70 | LY3023414 | 0.00246998519581 | -0.7413 | 0.7828 | 0.7825 | -1.0000 | 0.1908 | 0.6120 | 7.2607777184e-06 |
| MDA-MB-361 | THZ1 | 0.008546239 | -0.7383 | 0.6919 | 0.0322 | -0.9036 | 0.7783 | 0.9320 | 2.55e-15 |
| HCC1428 | LY3023414 | 4.66e-07 | -0.7374 | 1.2208 | 0.0032 | -1.0000 | 0.1242 | 0.3630 | 0.003559188 |
| HCC70 | MK 1775 | 0.000494343213706 | -0.7213 | 1.1390 | 0.0113 | -0.7848 | 0.3020 | 0.9292 | 4.21884749358e-15 |
| HCC1500 | GSK2334470 | -inf | -0.7194 | ||||||
| HCC1395 | THZ1 | 0.022043777 | -0.7138 | 0.5570 | 0.0343 | -0.6189 | 1.8271 | 0.9657 | 1.11e-16 |
| MDA-MB-134-VI | AZD2014 | -inf | -0.7122 | ||||||
| MDA-MB-361 | AZD2014 | 0.000105775 | -0.6868 | 1.1635 | 0.0173 | -1.0000 | 0.2155 | 0.9146 | 4.4e-14 |
| SUM1315MO2 | MK 1775 | 0.00109721 | -0.6828 | 0.9928 | 0.0075 | -0.4794 | 0.3502 | 0.6449 | 2.4e-06 |
| MCF 10A | THZ531 | 0.357116458529 | -0.6687 | 0.1492 | 0.5711 | -1.0000 | 2.3402 | 0.9921 | 1.11022302463e-16 |
| SUM1315MO2 | THZ1 | 0.21954393 | -0.6621 | 0.1975 | 0.4131 | -1.0000 | 1.7380 | 0.8819 | 2.54e-12 |
| BT-20 | MK 1775 | 1.80498033053 | -0.6583 | 0.2015 | 4.1869 | -1.0000 | 1.3057 | 0.9322 | 2.44249065418e-15 |
| MDA-MB-453 | LY3023414 | 0.000358181 | -0.6542 | 0.8640 | 0.5638 | -1.0000 | 0.1492 | 0.6094 | 7.89e-06 |
| MCF 10A | THZ1 | 0.0730835628731 | -0.6529 | 0.3312 | 0.2397 | -1.0000 | 0.9250 | 0.9692 | 1.11022302463e-16 |
| SK-BR-3 | THZ531 | 0.027628212 | -0.6438 | 0.5118 | 0.0388 | -0.5253 | 2.1073 | 0.9461 | 1.11e-16 |
| HCC1395 | Alvocidib | 0.123109246 | -0.6242 | 0.3359 | 0.3193 | -1.0000 | 1.1526 | 0.9075 | 1.2e-13 |
| BT-20 | LY3023414 | 0.00529380398207 | -0.6210 | 0.7635 | 0.9065 | -1.0000 | 0.2136 | 0.7707 | 1.01291124377e-08 |
| SK-BR-3 | MK 1775 | 0.230887652 | -0.6053 | 0.5073 | 2.0221 | -1.0000 | 0.5063 | 0.8951 | 5.72e-13 |
| MDA-MB-134-VI | THZ531 | 0.02115469 | -0.6052 | 0.6989 | 0.0314 | -0.7400 | 2.3004 | 0.9310 | 3e-15 |
| BT-20 | Alvocidib | 0.109020751309 | -0.6023 | 0.3436 | 0.2983 | -1.0000 | 1.0915 | 0.9859 | 1.11022302463e-16 |
| HCC1419 | LY3023414 | -inf | -0.6005 | ||||||
| HCC1395 | THZ531 | 0.082836127 | -0.5892 | 0.3780 | 0.1566 | -0.6873 | 1.3576 | 0.9575 | 1.11e-16 |
| AU565 | THZ1 | 0.018314242 | -0.5809 | 0.5779 | 0.0306 | -0.5110 | 1.3730 | 0.9728 | 1.11e-16 |
| HCC1806 | THZ1 | -inf | -0.5805 | ||||||
| HCC1395 | MK 1775 | 0.006597016 | -0.5660 | 0.8421 | 0.1385 | -0.8195 | 0.3187 | 0.9403 | 5.55e-16 |