Breast Cancer Profiling Project, Drug Sensitivity phase II: Fixed-cell GR measures of 33 breast cell lines and PDX lines to 16 small molecule perturbagens from library plate II. Dataset 2 of 2: Calculated dose response metrics - Dataset (ID:20355)

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Cell Small Molecule GR50 GRmax GR_AOC GEC50 GRinf GR Hill Coefficient GR r2 pval_GR
MCF 10A GSK2334470
15.0731115613
 0.8830 -0.0129 18.7770 -1.0000 5.0000 0.4636
0.000172093714918
MDA-MB-453 AZD5363
1.537709354
 0.1686 0.2591 1.2036 0.0741 0.6549 0.8588
2.35e-11
SUM149PT LY3023414
1.560308156
 -0.0238 0.2943 18.4015 -1.0000 0.4452 0.8188
5.32e-10
HCC38 Senexin B
15.63810324
 0.5236 0.1411 269.9088 -0.9985 0.3853 0.5885
1.51e-05
MDA-MB-468 SHP099
15.69903996
 0.5419 0.1218 54.5394 -0.4817 0.5418 0.5522
4.35e-05
CAL-85-1 Rucaparib
15.9069887
 0.3496 0.2765 1000.0000 -0.6758 0.2065 0.3127
0.009204617
HCC1143 Senexin B
16.15394735
 0.4142 0.1852 1000.0000 -0.7697 0.2259 0.6559
1.62e-06
MDA-MB-468 Ulixertinib
1.621194239
 0.3429 0.2660 0.2539 0.3452 0.6324 0.9377
8.88e-16
HME1 SHP099
16.29543423
 0.6344 0.0890 71.5373 -1.0000 0.7426 0.7358
5.94e-08
HCC70 Senexin B
16.531300381
 0.4078 0.2194 1000.0000 -0.7732 0.2278 0.4788
0.000290238214042
HCC1806 Ribociclib
168.232015049
 0.6251 0.1419 317.3038 -0.1285 0.3606 0.3213
0.00787309835959
HCC1143 Ulixertinib
1.718095034
 0.0344 0.2458 19.1869 -1.0000 0.4553 0.8884
1.25e-12
BT-20 AZD5363
1.72900360981
 0.1717 0.3013 86.6237 -1.0000 0.2807 0.8604
2.05393480002e-11
HCC1143 RO-3306
1.73126532
 -0.1079 0.2418 3.9460 -0.5002 0.8416 0.9451
2.22e-16
HCC70 AZD6738
1.73555477677
 -0.5435 0.2705 4.4527 -1.0000 1.1660 0.9336
1.88737914186e-15
MDA-MB-361 Senexin B
1.759420996
 0.3235 0.2847 157.3873 -1.0000 0.2445 0.4951
0.000194933
SUM1315MO2 Rucaparib
17.80541463
 0.2942 0.3317 1000.0000 -0.3226 0.1236 0.3203
0.008018079
HCC1806 AZD2014
1.79837045193
 0.3811 0.3438 2.3555 -0.0311 0.2238 0.8823
2.43538522682e-12
BT-20 MK 1775
1.80498033053
 -0.6583 0.2015 4.1869 -1.0000 1.3057 0.9322
2.44249065418e-15
SUM159PT Rucaparib
1.81722e+11
 0.7797 0.0896 999.9789 0.4809 0.1718 0.3608
0.003721786
MDA-MB-231 GSK2334470
186.872396201
 0.5782 0.1537 1000.0000 -0.2356 0.2301 0.5852
1.67193823907e-05
SUM149PT AZD2014
1.870533874
 0.3557 0.3916 1000.0000 -0.6285 0.1296 0.8137
7.57e-10
HCC1395 Ulixertinib
1.871580782
 0.1659 0.2498 4.1054 -0.2114 0.4489 0.7753
7.87e-09
Hs 578T GSK2334470
19.04682987
 0.5381 0.1513 619.2531 -1.0000 0.3155 0.9434
2.22e-16
SUM159PT Ulixertinib
1.943050817
 0.1333 0.2476 22.3099 -1.0000 0.4501 0.9582
1.11e-16