Breast Cancer Profiling Project, Drug Sensitivity phase II: Fixed-cell GR measures of 33 breast cell lines and PDX lines to 16 small molecule perturbagens from library plate II. Dataset 2 of 2: Calculated dose response metrics - Dataset (ID:20355)
Download: Excel (XLSX), Comma-separated (CSV)
| Cell | Small Molecule | GR50 | GRmax | GR_AOC | GEC50 | GRinf | GR Hill Coefficient | GR r2 | pval_GR |
|---|---|---|---|---|---|---|---|---|---|
| MDA-MB-361 | Alvocidib | 0.089713792 | -0.4956 | 0.4193 | 0.3494 | -1.0000 | 0.8080 | 0.8065 | 1.21e-09 |
| MDA-MB-453 | BMS-265246 | 0.757165765 | 0.2593 | 0.3794 | 214.7431 | -1.0000 | 0.1945 | 0.7673 | 1.21e-08 |
| MDA-MB-453 | AZD6738 | 4.833057791 | -0.1286 | 0.1011 | 8.9747 | -1.0000 | 1.7750 | 0.9231 | 1.19e-14 |
| HCC1937 | Alvocidib | 0.166518918 | -0.2096 | 0.2105 | 0.2327 | -0.3409 | 1.5542 | 0.9076 | 1.17e-13 |
| Hs 578T | Rucaparib | 478.5688189 | 0.6723 | 0.1013 | 1000.0000 | -0.1130 | 0.2766 | 0.5974 | 1.15e-05 |
| BT-20 | AZD2014 | 0.129099948542 | 0.1187 | 0.4911 | 0.6794 | -0.2850 | 0.2716 | 0.8667 | 1.14693810005e-11 |
| HCC1954 | LY3023414 | 0.000261242275613 | -0.4250 | 0.8272 | 1.0238 | -1.0000 | 0.1328 | 0.7220 | 1.12126955498e-07 |
| MDA-MB-468 | THZ1 | 0.023258754 | -0.4302 | 0.5137 | 0.0368 | -0.3586 | 1.1755 | 0.9657 | 1.11e-16 |
| HCC1937 | THZ1 | 0.064677099 | -0.3919 | 0.3250 | 0.0812 | -0.3041 | 2.0906 | 0.9470 | 1.11e-16 |
| HCC38 | MK 1775 | 0.004188304 | -0.4069 | 0.9360 | 0.0178 | -0.4523 | 0.4447 | 0.9813 | 1.11e-16 |
| HCC38 | BMS-265246 | 0.00394749 | -0.0214 | 0.7767 | 0.0054 | -0.0686 | 0.4043 | 0.9575 | 1.11e-16 |
| HCC38 | Alvocidib | 0.139603749 | -0.4046 | 0.2799 | 0.3955 | -0.9001 | 0.9887 | 0.9746 | 1.11e-16 |
| AU565 | Alvocidib | 0.087632457 | -0.5502 | 0.3751 | 0.2006 | -0.8064 | 1.1595 | 0.9601 | 1.11e-16 |
| HCC38 | RO-3306 | 7.435051917 | -0.2110 | 0.0493 | 9.2621 | -1.0000 | 5.0000 | 0.9513 | 1.11e-16 |
| HCC38 | THZ1 | 0.02382594 | -0.5420 | 0.5167 | 0.0405 | -0.4828 | 1.2756 | 0.9829 | 1.11e-16 |
| HCC38 | THZ531 | 0.179180276 | -0.3210 | 0.1885 | 0.2224 | -0.3480 | 2.4453 | 0.9711 | 1.11e-16 |
| Hs 578T | MK 1775 | 0.014507078 | -0.3462 | 0.7648 | 0.0762 | -0.4564 | 0.3909 | 0.9740 | 1.11e-16 |
| Hs 578T | AZD2014 | 0.068067431 | 0.2555 | 0.5090 | 0.0201 | 0.1834 | 0.3744 | 0.9704 | 1.11e-16 |
| Hs 578T | AZD6738 | 5.182870146 | -0.0390 | 0.0818 | 10.0001 | -1.0000 | 1.6716 | 0.9755 | 1.11e-16 |
| Hs 578T | Ulixertinib | 1.12758771 | 0.2421 | 0.3284 | 1.7251 | -0.0883 | 0.3825 | 0.9567 | 1.11e-16 |
| Hs 578T | Alvocidib | 0.148558558 | -0.2518 | 0.2560 | 0.2079 | -0.3548 | 1.5955 | 0.9912 | 1.11e-16 |
| Hs 578T | RO-3306 | 4.300129294 | -0.0976 | 0.1258 | 9.7624 | -1.0000 | 1.3399 | 0.9749 | 1.11e-16 |
| Hs 578T | THZ1 | 0.018250125 | -0.4195 | 0.5223 | 0.0232 | -0.3000 | 1.9491 | 0.9905 | 1.11e-16 |
| Hs 578T | THZ531 | 0.048528081 | -0.2670 | 0.3750 | 0.0565 | -0.2217 | 2.4067 | 0.9945 | 1.11e-16 |
| HME1 | AZD2014 | 0.017460717 | 0.1122 | 0.5969 | 0.3948 | -0.3458 | 0.1686 | 0.9585 | 1.11e-16 |