Breast Cancer Profiling Project, Drug Sensitivity phase II: Fixed-cell GR measures of 33 breast cell lines and PDX lines to 16 small molecule perturbagens from library plate II. Dataset 2 of 2: Calculated dose response metrics - Dataset (ID:20355)
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| Cell | Small Molecule | GR50 | GRmax | GR_AOC | GEC50 | GRinf | GR Hill Coefficient | GR r2 | pval_GR |
|---|---|---|---|---|---|---|---|---|---|
| CAL-120 | RO-3306 | 8.527233934 | 0.1534 | 0.0250 | 10.6226 | -1.0000 | 5.0000 | 0.9423 | 3.33e-16 |
| SK-BR-3 | GSK2334470 | inf | 0.1727 | 0.3229 | 0.0048 | 0.6054 | 5.0000 | 0.3843 | 0.002330067 |
| BT-20 | AZD6738 | 5.68190940846 | 0.1069 | -0.0571 | 5.4098 | 0.1088 | 5.0000 | 0.8298 | 2.43821740575e-10 |
| MDA-MB-453 | SHP099 | 11.54207272 | 0.7015 | 0.0178 | 14.3805 | -1.0000 | 4.9966 | 0.3055 | 0.010499523 |
| CAMA-1 | AZD6738 | 8.908669378 | 0.2804 | -0.0237 | 11.1124 | -1.0000 | 4.9704 | 0.6787 | 6.86e-07 |
| MCF 10A | Senexin B | 13.2364754711 | 0.8231 | -0.0310 | 16.5655 | -1.0000 | 4.8970 | 0.5533 | 1.42287035656e-05 |
| SUM159PT | AZD6738 | 10.0174126 | 0.4273 | -0.0067 | 12.5628 | -1.0000 | 4.8522 | 0.9120 | 6.41e-14 |
| HCC1937 | THZ531 | 0.264094355 | -0.3101 | 0.1622 | 0.2933 | -0.2919 | 4.3814 | 0.9206 | 1.75e-14 |
| HCC70 | THZ531 | 0.0645734883647 | -0.8397 | 0.4266 | 0.0849 | -0.7832 | 3.4505 | 0.9663 | 1.11022302463e-16 |
| T47D | RO-3306 | 7.208767727 | -0.0474 | 0.1168 | 9.9142 | -1.0000 | 3.4475 | 0.8495 | 5.24e-11 |
| MDA-MB-157 | THZ531 | 0.060618587 | -0.7599 | 0.4261 | 0.0784 | -0.6567 | 3.2544 | 0.9596 | 1.11e-16 |
| HCC1428 | RO-3306 | 3.430055795 | -0.4441 | 0.0143 | 3.8909 | -0.2512 | 3.2292 | 0.3585 | 0.003891828 |
| MDA-MB-231 | AZD6738 | 8.82761747838 | 0.3448 | -0.0384 | 12.4996 | -0.9998 | 3.1583 | 0.8459 | 7.04556413211e-11 |
| CAL-51 | RO-3306 | 8.346101408 | 0.1772 | 0.0379 | 11.9039 | -1.0000 | 3.0941 | 0.9243 | 9.77e-15 |
| HCC1954 | RO-3306 | 6.64148500206 | -0.1134 | 0.0533 | 9.5343 | -1.0000 | 3.0385 | 0.9127 | 5.7620574978e-14 |
| SUM159PT | RO-3306 | 7.498110755 | 0.1030 | 0.0581 | 11.0876 | -1.0000 | 2.8085 | 0.9796 | 1.11e-16 |
| BT-20 | THZ1 | 0.497469085347 | -0.4365 | 0.0947 | 0.7408 | -1.0000 | 2.7590 | 0.9734 | 1.11022302463e-16 |
| MCF 10A | SHP099 | 13.33532157 | 0.6599 | 0.0155 | 20.0345 | -1.0000 | 2.6990 | 0.8458 | 7.1e-11 |
| HCC1143 | THZ1 | 0.026504565 | -0.2975 | 0.4699 | 0.0315 | -0.2909 | 2.6729 | 0.9872 | 1.11e-16 |
| SUM159PT | THZ531 | 1.158729591 | 0.6103 | 0.0475 | 1.7617 | -1.0000 | 2.6222 | 0.8700 | 8.37e-12 |
| HCC1143 | THZ531 | 0.129709951 | -0.2293 | 0.2435 | 0.1509 | -0.2433 | 2.6173 | 0.9825 | 1.11e-16 |
| CAL-85-1 | Alvocidib | 0.160024022 | -0.3171 | 0.3835 | 0.1856 | -0.2356 | 2.6082 | 0.7113 | 1.8e-07 |
| HME1 | THZ531 | 0.22121156 | -0.1882 | 0.1768 | 0.2567 | -0.2330 | 2.5689 | 0.9759 | 1.11e-16 |
| HCC1419 | THZ531 | 0.159567693 | -0.3116 | 0.2249 | 0.1946 | -0.3196 | 2.4891 | 0.9564 | 1.11e-16 |
| MCF 10A | RO-3306 | 5.973258525 | -0.0959 | 0.0874 | 9.3379 | -1.0000 | 2.4589 | 0.9848 | 1.11e-16 |