Breast Cancer Deubiquitinating Enzyme (DUB) Inhibitor Profiling: Fixed-cell GR measures of 21 breast cell lines to 32 small molecule perturbagens. Dataset 2 of 2: Calculated dose response metrics. - Dataset (ID:20351)
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| Cell | Small Molecule | Treatment Duration | GR50 | GRmax | GR_AOC | GEC50 | GRinf | hGR |
|---|---|---|---|---|---|---|---|---|
| PDX1328 | Vialinin A | 72 | 6.5234902309 | -0.8259 | 0.3553 | 12.0354 | -0.9870 | 1.7796 |
| MDA-MB-134-VI | SJB3-019A | 72 | 0.38974102992 | -0.8219 | 0.9800 | 0.5388 | -0.8154 | 2.9868 |
| BT-20 | Mitoxantrone | 72 | 0.00114283548045 | -0.8192 | 1.3912 | 0.0267 | -0.9144 | 0.3300 |
| HCC1428 | P22077 | 72 | 3.38223139313 | -0.8186 | 0.5185 | 5.0583 | -0.8189 | 2.4098 |
| HCC1954 | P22077 | 72 | 3.99414837065 | -0.8173 | 0.3966 | 8.7096 | -0.9912 | 1.4017 |
| SK-BR-3 | HY-17541A | 72 | 6.05256867179 | -0.8127 | 0.3348 | 15.3356 | -1.0000 | 1.1817 |
| CAMA-1 | Mitoxantrone | 72 | 0.0062993374498 | -0.8126 | 1.3228 | 0.0295 | -0.6695 | 0.5504 |
| HCC1428 | HY-17541A | 72 | 2.47757925824 | -0.8052 | 0.5062 | 7.7740 | -1.0000 | 0.9607 |
| HCC202 | P22077 | 72 | 9.91449173635 | -0.8050 | 0.3064 | 12.0209 | -0.8101 | 5.0000 |
| HCC1428 | Degrasyn | 72 | 1.70453075174 | -0.8048 | 0.5951 | 3.0602 | -0.7743 | 1.5987 |
| BT-20 | P22077 | 72 | 5.68690045385 | -0.8029 | 0.3725 | 7.9927 | -0.8136 | 2.8380 |
| HCC1500 | Trifluoperazine | 72 | 6.81100307422 | -0.8014 | 0.3931 | 10.4325 | -0.8483 | 2.3266 |
| HCC1428 | MI-2 | 72 | 1.03571191058 | -0.7986 | 0.7440 | 1.3395 | -0.7690 | 3.6211 |
| BT-20 | Trifluoperazine | 72 | 12.3504591925 | -0.7940 | 0.2886 | 14.9777 | -0.8115 | 5.0000 |
| HCC1428 | SJB3-019A | 72 | 0.367074889212 | -0.7873 | 0.9956 | 0.4852 | -0.7833 | 3.3771 |
| MDA-MB-361 | SB1-F-21 | 72 | 0.683787272085 | -0.7860 | 0.7684 | 0.8135 | -0.6777 | 4.9337 |
| MDA-MB-361 | MI-2 | 72 | 3.80487472111 | -0.7848 | 0.4779 | 4.6826 | -0.7574 | 4.4428 |
| BT-20 | Pimozide | 72 | 10.6841586302 | -0.7844 | 0.2746 | 12.9223 | -0.7941 | 5.0000 |
| HCC1428 | Trifluoperazine | 72 | 7.02071798246 | -0.7839 | 0.3754 | 12.0126 | -0.9425 | 1.9727 |
| HCC202 | SB1-F-21 | 72 | 0.441545872924 | -0.7837 | 0.7543 | 0.9431 | -0.7246 | 1.1804 |
| HCC1419 | Degrasyn | 72 | 2.04026623653 | -0.7805 | 0.5512 | 2.7698 | -0.7166 | 2.9086 |
| HCC1954 | SB1-F-21 | 72 | 0.554362808497 | -0.7800 | 0.7854 | 0.7812 | -0.6692 | 2.4761 |
| MDA-MB-361 | Sepantronium | 72 | 1.5586359565 | -0.7783 | 0.5362 | 2.4507 | -0.7241 | 1.9784 |
| HCC1954 | Trifluoperazine | 72 | 10.7631304172 | -0.7744 | 0.2931 | 13.0385 | -0.7772 | 4.8899 |
| MCF7 | Mitoxantrone | 72 | 0.0169144908308 | -0.7736 | 1.0817 | 0.3991 | -1.0000 | 0.3475 |