Breast Cancer Deubiquitinating Enzyme (DUB) Inhibitor Profiling: Fixed-cell GR measures of 21 breast cell lines to 32 small molecule perturbagens. Dataset 2 of 2: Calculated dose response metrics. - Dataset (ID:20351)

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Cell Small Molecule Treatment Duration GR50 GRmax GR_AOC GEC50 GRinf hGR
MDA-MB-231 STK547622 72
inf
 0.9830 -0.0027 0.0000 1.0000 0.0100
HCC1500 z-VAE(OMe)-fmk 72
inf
 1.1021 0.0136 0.0000 1.0000 0.0100
MDA-MB-361 STK547622 72
inf
 1.0471 -0.1279 0.0000 1.0000 0.0100
Hs 578T HY-17542 72
inf
 0.9246 -0.0205 0.0000 1.0000 0.0100
MDA-MB-361 5-(4-fluorophenyl)-3-hydroxy-4-(5-methyl-2-furoyl)-1-(3-pyridinylmethyl)-1,5-dihydro-2H-pyrrol-2-one 72
inf
 1.0999 0.0175 0.0000 1.0000 0.0100
HCC202 USP7-IN-1 72
inf
 0.8501 -0.0200 0.0000 1.0000 0.0100
HCC202 GW7647 72
inf
 0.8031 -0.0688 0.0000 1.0000 0.0100
Hs 578T GW7647 72
inf
 0.8977 -0.0280 0.0000 1.0000 0.0100
BT-20 IU1 72
inf
 1.1490 -0.1850 0.0000 1.0000 0.0100
BT-20 HY-17542 72
inf
 1.0099 -0.0181 0.0000 1.0000 0.0100
MDA-MB-361 HY-17542 72
inf
 0.8632 -0.0548 0.0000 1.0000 0.0100
BT-20 GW7647 72
inf
 0.7093 -0.0625 0.0000 1.0000 0.0100
PDX1328 GW7647 72
inf
 0.8376 -0.0784 0.0000 1.0000 0.0100
MCF7 z-VAE(OMe)-fmk 72
inf
 1.0118 -0.0177 0.0000 1.0000 0.0100
MDA-MB-361 IU1 72
inf
 0.7838 -0.0464 0.0000 1.0000 0.0100
HCC1419 5-(4-fluorophenyl)-3-hydroxy-4-(5-methyl-2-furoyl)-1-(3-pyridinylmethyl)-1,5-dihydro-2H-pyrrol-2-one 72
inf
 0.9816 -0.0058 0.0000 1.0000 0.0100
MDA-MB-134-VI GW7647 72
inf
 1.0004 -0.0983 0.0000 1.0000 0.0100
MCF7 STK547622 72
inf
 1.0181 -0.0093 0.0000 1.0000 0.0100
MCF7 5-(4-fluorophenyl)-3-hydroxy-4-(5-methyl-2-furoyl)-1-(3-pyridinylmethyl)-1,5-dihydro-2H-pyrrol-2-one 72
inf
 1.0084 -0.0062 0.0000 1.0000 0.0100
HCC1937 STK547622 72
inf
 1.0316 -0.0512 0.0000 1.0000 0.0100
HCC1937 z-VAE(OMe)-fmk 72
inf
 0.9933 -0.0106 0.0000 1.0000 0.0100
PDX1328 SB1-F-22 72
inf
 1.0347 -0.2404 0.0000 1.0000 0.0100