Breast Cancer Deubiquitinating Enzyme (DUB) Inhibitor Profiling: Fixed-cell GR measures of 21 breast cell lines to 32 small molecule perturbagens. Dataset 2 of 2: Calculated dose response metrics. - Dataset (ID:20351)
Download: Excel (XLSX), Comma-separated (CSV)
| Cell | Small Molecule | Treatment Duration | GR50 | GRmax | GR_AOC | GEC50 | GRinf | hGR |
|---|---|---|---|---|---|---|---|---|
| HCC1419 | HY-17541A | 72 | 5.08410753288 | -0.7228 | 0.3771 | 13.2847 | -1.0000 | 1.1438 |
| HCC1806 | LDN57444 | 72 | 20.8632565992 | -0.2951 | 0.1515 | 37.1169 | -1.0000 | 1.9070 |
| HCC1500 | HY-17541A | 72 | 6.22982678245 | -0.6101 | 0.3035 | 17.0198 | -1.0000 | 1.0931 |
| CAMA-1 | HY-17541A | 72 | 7.52712235452 | -0.7494 | 0.2920 | 17.5656 | -1.0000 | 1.2964 |
| HCC1428 | Pimozide | 72 | 5.48832397235 | -0.7126 | 0.4005 | 12.0349 | -1.0000 | 1.3992 |
| HCC1419 | GW7647 | 72 | 39.4857944397 | -0.0439 | 0.0074 | 49.1887 | -1.0000 | 5.0000 |
| HCC1419 | USP7-IN-1 | 72 | 44.7550079567 | 0.4088 | 0.0472 | 76.1826 | -1.0000 | 2.0653 |
| BT-549 | USP7-IN-1 | 72 | 94.531181628 | 0.8209 | 0.0177 | 166.1357 | -1.0000 | 1.9483 |
| CAMA-1 | HBX19818 | 72 | 24.9121589631 | -0.4378 | 0.1232 | 36.6256 | -1.0000 | 2.8506 |
| BT-549 | HBX19818 | 72 | 28.4956034945 | -0.3396 | 0.1206 | 40.2238 | -1.0000 | 3.1871 |
| HCC1500 | ML-323 | 72 | 22.8896968406 | 0.1643 | 0.1263 | 77.3652 | -1.0000 | 0.9021 |
| BT-549 | HY-17541A | 72 | 16.8403527969 | -0.5863 | 0.1928 | 28.1688 | -1.0000 | 2.1356 |
| HCC1428 | LDN57444 | 72 | 12.549009736 | -0.0136 | 0.2378 | 89.8320 | -1.0000 | 0.5582 |
| CAMA-1 | Doxycycline | 72 | 20.1165363681 | -0.1002 | 0.1702 | 44.6977 | -1.0000 | 1.3761 |
| CAMA-1 | ML-323 | 72 | 28.720597579 | 0.2218 | 0.1069 | 83.5494 | -1.0000 | 1.0288 |
| HCC1500 | USP7-IN-1 | 72 | 51.9923039456 | 0.4861 | 0.0630 | 130.5080 | -1.0000 | 1.1937 |
| HCC1419 | Doxycycline | 72 | 29.9947198826 | 0.0713 | 0.0985 | 58.5488 | -1.0000 | 1.6426 |
| HCC1419 | Pimozide | 72 | 6.13162921953 | -0.7003 | 0.3602 | 13.2581 | -1.0000 | 1.4246 |
| BT-549 | ML-323 | 72 | 74.3999913582 | 0.5763 | 0.0892 | 442.2433 | -1.0000 | 0.6164 |
| HCC1419 | HBX19818 | 72 | 18.9629402973 | -0.3826 | 0.1144 | 33.7889 | -1.0000 | 1.9019 |
| CAMA-1 | USP7-IN-1 | 72 | 90.407874652 | 0.7005 | 0.0265 | 239.6012 | -1.0000 | 1.1272 |
| HCC1419 | Mitoxantrone | 72 | 0.0324309949523 | -0.8993 | 1.0606 | 0.5551 | -1.0000 | 0.3868 |
| CAMA-1 | SB1-F-22 | 72 | 43.6088606735 | 0.4408 | 0.0565 | 156.5267 | -1.0000 | 0.8597 |
| MCF7 | ML-323 | 72 | 34.9041902184 | 0.3934 | 0.1213 | 138.0045 | -1.0000 | 0.7992 |
| MCF 10A | ML-323 | 72 | 66.3873318694 | 0.5514 | 0.0860 | 333.5126 | -1.0000 | 0.6806 |