Breast Cancer Deubiquitinating Enzyme (DUB) Inhibitor Profiling: Fixed-cell GR measures of 21 breast cell lines to 32 small molecule perturbagens. Dataset 2 of 2: Calculated dose response metrics. - Dataset (ID:20351)
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| Cell | Small Molecule | Treatment Duration | GR50 | GRmax | GR_AOC | GEC50 | GRinf | hGR |
|---|---|---|---|---|---|---|---|---|
| HCC1937 | Vialinin A | 72 | 8.32590505669 | -0.2754 | 0.2500 | 10.0381 | -0.2833 | 2.4000 |
| MDA-MB-361 | Pevonedistat | 72 | 0.105133263812 | -0.3279 | 0.8618 | 0.1270 | -0.2800 | 2.3487 |
| MCF 10A | P22077 | 72 | 4.7951144345 | -0.3461 | 0.3384 | 5.2700 | -0.2789 | 4.6944 |
| Hs 578T | HY-50736 | 72 | 0.206859851043 | -0.1514 | 0.8157 | 0.2773 | -0.2770 | 1.5040 |
| HCC1500 | Spautin-1 | 72 | 3.41360576159 | -0.0935 | 0.3577 | 5.5741 | -0.2758 | 0.8959 |
| T47D | HY-50737A | 72 | 4.05537288518 | -0.2242 | 0.3936 | 4.4286 | -0.2752 | 4.9803 |
| MDA-MB-231 | SJB2-043 | 72 | 0.531717815307 | -0.3147 | 0.5316 | 0.6346 | -0.2713 | 2.4513 |
| HCC1954 | 1247825-37-1 | 72 | 9.27208726827 | -0.2049 | 0.2775 | 11.2541 | -0.2697 | 2.2268 |
| MCF7 | Vialinin A | 72 | 6.03216171414 | -0.2574 | 0.2814 | 7.1157 | -0.2692 | 2.6069 |
| HCC1806 | HY-50737A | 72 | 11.8311020156 | -0.2747 | 0.2199 | 12.8932 | -0.2685 | 5.0000 |
| BT-549 | Degrasyn | 72 | 2.03345345035 | -0.2544 | 0.4762 | 2.2668 | -0.2681 | 3.9517 |
| MCF7 | SJB3-019A | 72 | 0.181501994106 | -0.2939 | 0.8146 | 0.2092 | -0.2679 | 3.0164 |
| HCC1428 | 1247825-37-1 | 72 | 4.93495492588 | -0.2477 | 0.3384 | 6.4761 | -0.2632 | 1.5561 |
| PDXHCI002 | 1247825-37-1 | 72 | 7.7918126167 | -0.2501 | 0.2337 | 8.8742 | -0.2609 | 3.2282 |
| MCF 10A | MI-2 | 72 | 5.79831624395 | -0.2953 | 0.3052 | 6.4633 | -0.2594 | 3.8494 |
| MCF7 | HBX 41108 | 72 | 0.390147535667 | -0.2149 | 0.6730 | 0.5376 | -0.2563 | 1.2906 |
| HCC1806 | Pevonedistat | 72 | 0.0335529495438 | -0.2883 | 1.0267 | 0.0419 | -0.2494 | 1.8239 |
| MDA-MB-231 | Vialinin A | 72 | 11.5071057567 | -0.1762 | 0.1553 | 14.2645 | -0.2485 | 1.8785 |
| T47D | SB1-F-22 | 72 | 156.804339896 | 0.7134 | 0.0621 | 286.2396 | -0.2481 | 0.6696 |
| BT-549 | Doxycycline | 72 | 16.3310783662 | -0.1425 | 0.1726 | 19.1261 | -0.2467 | 2.5386 |
| HCC1954 | SJB2-043 | 72 | 1.24122713519 | -0.3522 | 0.3712 | 1.3752 | -0.2369 | 3.7831 |
| MDA-MB-361 | SJB2-043 | 72 | 1.59047305005 | -0.2559 | 0.3538 | 1.7814 | -0.2365 | 3.4159 |
| MCF7 | HY-50737A | 72 | 0.230613494355 | -0.1986 | 0.7394 | 0.3067 | -0.2336 | 1.3443 |
| BT-549 | Pevonedistat | 72 | 0.209348073627 | -0.2452 | 0.7301 | 0.2903 | -0.2281 | 1.1500 |
| MCF 10A | Mitoxantrone | 72 | 0.017667155736 | -0.2638 | 0.9981 | 0.0292 | -0.2233 | 0.7335 |