Breast Cancer Deubiquitinating Enzyme (DUB) Inhibitor Profiling: Fixed-cell GR measures of 21 breast cell lines to 32 small molecule perturbagens. Dataset 2 of 2: Calculated dose response metrics. - Dataset (ID:20351)
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| Cell | Small Molecule | Treatment Duration | GR50 | GRmax | GR_AOC | GEC50 | GRinf | hGR |
|---|---|---|---|---|---|---|---|---|
| HCC1937 | SJB2-043 | 72 | 0.396049351375 | -0.5581 | 0.6542 | 0.6443 | -0.5754 | 1.5740 |
| PDX1258 | b-AP15 | 72 | 0.186230489102 | -0.6381 | 0.9074 | 0.3277 | -0.5748 | 1.3539 |
| HCC1428 | b-AP15 | 72 | 0.0647974209893 | -0.7164 | 1.1058 | 0.1041 | -0.5730 | 1.6094 |
| HCC1937 | MI-2 | 72 | 1.5435411034 | -0.5588 | 0.5652 | 2.1666 | -0.5722 | 2.2498 |
| HCC1954 | HY-50737A | 72 | 0.358997904545 | -0.5501 | 0.8394 | 0.6036 | -0.5719 | 1.4677 |
| PDX1328 | Sepantronium | 72 | 0.0218983386219 | -0.9670 | 1.5930 | 0.0347 | -0.5708 | 1.6579 |
| T47D | Doxycycline | 72 | 15.8755936591 | -0.2262 | 0.2230 | 24.9860 | -0.5704 | 1.6784 |
| PDX1258 | SJB3-019A | 72 | 0.465986460631 | -0.5823 | 0.7715 | 0.5616 | -0.5695 | 4.0736 |
| SK-BR-3 | Vialinin A | 72 | 6.57450356831 | -0.4313 | 0.2897 | 11.2296 | -0.5685 | 1.4185 |
| HCC1806 | MI-2 | 72 | 3.9059429509 | -0.5803 | 0.4525 | 4.7751 | -0.5651 | 3.7640 |
| BT-20 | HBX 41108 | 72 | 0.575869637316 | -0.5895 | 0.6999 | 1.0838 | -0.5642 | 1.1945 |
| PDXHCI002 | SJB3-019A | 72 | 0.305258876445 | -0.5784 | 0.8656 | 0.4150 | -0.5629 | 2.4552 |
| HCC1428 | HBX 41108 | 72 | 0.0712282775341 | -0.6506 | 1.0708 | 0.1364 | -0.5624 | 1.1606 |
| T47D | SJB3-019A | 72 | 0.197447266274 | -0.5628 | 0.9021 | 0.3562 | -0.5619 | 1.2767 |
| PDX1258 | HBX 41108 | 72 | 0.19093097022 | -0.5289 | 0.8289 | 0.5067 | -0.5544 | 0.7646 |
| T47D | SB1-F-21 | 72 | 0.605682620995 | -0.5948 | 0.6994 | 0.9625 | -0.5534 | 1.6087 |
| HCC1500 | Vialinin A | 72 | 6.94264500958 | -0.4158 | 0.2869 | 11.1402 | -0.5530 | 1.5750 |
| PDXHCI002 | Mitoxantrone | 72 | 0.000170736912028 | -0.5642 | 1.3538 | 0.0014 | -0.5519 | 0.3578 |
| PDX1258 | Degrasyn | 72 | 2.04245876356 | -0.5884 | 0.5464 | 2.6223 | -0.5503 | 2.9704 |
| HCC1806 | SB1-F-21 | 72 | 2.13484035995 | -0.5380 | 0.5257 | 3.0789 | -0.5502 | 2.0265 |
| HCC1937 | Sepantronium | 72 | 0.0274217558915 | -0.5570 | 1.2238 | 0.0525 | -0.5494 | 1.1409 |
| PDX1258 | Sepantronium | 72 | 0.0944990954 | -0.5758 | 0.9903 | 0.1955 | -0.5482 | 1.0184 |
| PDXHCI002 | HBX19818 | 72 | 11.6902936105 | -0.5250 | 0.2522 | 14.0123 | -0.5432 | 4.0591 |
| HCC1500 | b-AP15 | 72 | 0.166633438938 | -0.5813 | 0.9654 | 0.2171 | -0.5410 | 2.7718 |
| SK-BR-3 | Degrasyn | 72 | 1.46725479038 | -0.5284 | 0.5755 | 2.0646 | -0.5400 | 2.1444 |