Breast Cancer Deubiquitinating Enzyme (DUB) Inhibitor Profiling: Fixed-cell GR measures of 21 breast cell lines to 32 small molecule perturbagens. Dataset 2 of 2: Calculated dose response metrics. - Dataset (ID:20351)
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| Cell | Small Molecule | Treatment Duration | GR50 | GRmax | GR_AOC | GEC50 | GRinf | hGR |
|---|---|---|---|---|---|---|---|---|
| HCC1419 | MI-2 | 72 | 0.8507722389 | -0.5904 | 0.7165 | 1.0642 | -0.5907 | 3.4840 |
| SK-BR-3 | SJB2-043 | 72 | 0.397342856958 | -0.6773 | 0.7194 | 0.5909 | -0.6730 | 2.1483 |
| BT-20 | LDN57444 | 72 | 0.273589049961 | -0.5384 | 0.7238 | 0.4768 | -0.3750 | 1.0074 |
| HCC1954 | MI-2 | 72 | 0.970176713855 | -0.7113 | 0.7248 | 1.1567 | -0.7047 | 5.0000 |
| BT-549 | Pevonedistat | 72 | 0.209348073627 | -0.2452 | 0.7301 | 0.2903 | -0.2281 | 1.1500 |
| HCC1954 | Pevonedistat | 72 | 0.316056841639 | -0.3881 | 0.7332 | 0.4991 | -0.3610 | 1.1895 |
| HCC1937 | HBX 41108 | 72 | 0.197216521638 | -0.4641 | 0.7356 | 1.4877 | -0.7065 | 0.4359 |
| MCF7 | b-AP15 | 72 | 0.3096452845 | -0.3697 | 0.7380 | 0.5354 | -0.3883 | 1.0497 |
| MCF7 | HY-50737A | 72 | 0.230613494355 | -0.1986 | 0.7394 | 0.3067 | -0.2336 | 1.3443 |
| HCC1428 | MI-2 | 72 | 1.03571191058 | -0.7986 | 0.7440 | 1.3395 | -0.7690 | 3.6211 |
| MCF 10A | b-AP15 | 72 | 0.247307753993 | -0.2223 | 0.7451 | 0.2767 | -0.2064 | 3.0780 |
| HCC1500 | SJB2-043 | 72 | 0.201434109876 | -0.4925 | 0.7459 | 0.2844 | -0.4547 | 1.8761 |
| MDA-MB-231 | MI-2 | 72 | 0.537364787333 | -0.5738 | 0.7460 | 0.7155 | -0.5046 | 2.4370 |
| BT-549 | MI-2 | 72 | 0.571326549598 | -0.4518 | 0.7504 | 0.6753 | -0.4619 | 3.9147 |
| HCC202 | MI-2 | 72 | 1.05934529798 | -0.7616 | 0.7515 | 1.3228 | -0.7564 | 4.1491 |
| HCC202 | SB1-F-21 | 72 | 0.441545872924 | -0.7837 | 0.7543 | 0.9431 | -0.7246 | 1.1804 |
| HCC1419 | HBX 41108 | 72 | 0.515725968644 | -0.7549 | 0.7581 | 1.8602 | -0.8858 | 0.7947 |
| CAMA-1 | MI-2 | 72 | 0.530718147156 | -0.4633 | 0.7592 | 0.6284 | -0.4414 | 3.7466 |
| HCC1500 | Sepantronium | 72 | 0.48222369882 | -0.6675 | 0.7593 | 0.9213 | -0.6468 | 1.2822 |
| PDX1328 | SB1-F-21 | 72 | 0.844936773852 | -0.9869 | 0.7625 | 1.8713 | -1.0000 | 1.3817 |
| MDA-MB-231 | SJB3-019A | 72 | 0.347120433929 | -0.3529 | 0.7664 | 0.4218 | -0.3365 | 2.6418 |
| MDA-MB-361 | SB1-F-21 | 72 | 0.683787272085 | -0.7860 | 0.7684 | 0.8135 | -0.6777 | 4.9337 |
| SK-BR-3 | HY-50737A | 72 | 0.478741799562 | -0.5895 | 0.7685 | 0.6829 | -0.5240 | 2.0185 |
| HCC1937 | Pevonedistat | 72 | 0.0855702491458 | -0.1081 | 0.7701 | 0.0915 | -0.0540 | 1.5279 |
| SK-BR-3 | SB1-F-21 | 72 | 0.26463962594 | -0.4562 | 0.7702 | 0.4655 | -0.4299 | 1.0988 |