Breast Cancer Deubiquitinating Enzyme (DUB) Inhibitor Profiling: Fixed-cell GR measures of 21 breast cell lines to 32 small molecule perturbagens. Dataset 2 of 2: Calculated dose response metrics. - Dataset (ID:20351)
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| Cell | Small Molecule | Treatment Duration | GR50 | GRmax | GR_AOC | GEC50 | GRinf | hGR |
|---|---|---|---|---|---|---|---|---|
| SK-BR-3 | Degrasyn | 72 | 1.46725479038 | -0.5284 | 0.5755 | 2.0646 | -0.5400 | 2.1444 |
| Hs 578T | MI-2 | 72 | 1.32338090995 | -0.3256 | 0.5792 | 1.5805 | -0.3890 | 3.2415 |
| MDA-MB-231 | HY-50736 | 72 | 1.15891799404 | -0.4598 | 0.5826 | 1.4403 | -0.4143 | 2.7766 |
| MCF 10A | HBX 41108 | 72 | 0.57601885416 | -0.0685 | 0.5834 | 0.6298 | -0.1204 | 2.4159 |
| T47D | SJB2-043 | 72 | 0.418884416082 | -0.3821 | 0.5842 | 0.6165 | -0.3642 | 1.4158 |
| Hs 578T | HY-50737A | 72 | 1.00080504529 | -0.3945 | 0.5891 | 1.4659 | -0.3655 | 1.4376 |
| HCC1500 | Degrasyn | 72 | 1.3319409029 | -0.5824 | 0.5931 | 1.7551 | -0.5299 | 2.6195 |
| HCC1428 | Degrasyn | 72 | 1.70453075174 | -0.8048 | 0.5951 | 3.0602 | -0.7743 | 1.5987 |
| MCF7 | SJB2-043 | 72 | 0.361790238142 | -0.2773 | 0.6009 | 0.4120 | -0.2857 | 3.4782 |
| CAMA-1 | Degrasyn | 72 | 1.91400918301 | -0.6784 | 0.6041 | 2.6284 | -0.6527 | 2.6337 |
| Hs 578T | Degrasyn | 72 | 1.34100869906 | -0.4283 | 0.6057 | 1.6245 | -0.4514 | 3.3543 |
| Hs 578T | HBX 41108 | 72 | 0.833261758014 | -0.3648 | 0.6116 | 1.1826 | -0.3412 | 1.4860 |
| PDXHCI002 | Degrasyn | 72 | 1.85435730216 | -0.6095 | 0.6125 | 2.8224 | -0.6043 | 1.8864 |
| T47D | HBX 41108 | 72 | 1.00606977934 | -0.4470 | 0.6172 | 1.2542 | -0.4170 | 2.7516 |
| MDA-MB-231 | SB1-F-21 | 72 | 0.508989399047 | -0.2031 | 0.6186 | 0.6310 | -0.2064 | 1.6087 |
| HCC1954 | HBX 41108 | 72 | 0.783598911134 | -0.6088 | 0.6215 | 2.0015 | -0.6718 | 0.9082 |
| PDX1328 | Degrasyn | 72 | 2.23838869532 | -0.9056 | 0.6219 | 3.3568 | -0.9207 | 2.5770 |
| HCC202 | HBX 41108 | 72 | 0.683600987561 | -0.5099 | 0.6221 | 3.3736 | -0.8219 | 0.6090 |
| PDXHCI002 | HBX 41108 | 72 | 0.569584571739 | -0.3596 | 0.6226 | 0.9572 | -0.3632 | 1.0518 |
| PDXHCI002 | HY-50736 | 72 | 0.868083561962 | -0.2659 | 0.6264 | 1.0125 | -0.3271 | 3.2699 |
| BT-20 | Degrasyn | 72 | 1.87496854329 | -0.6371 | 0.6302 | 2.2190 | -0.6608 | 5.0000 |
| HCC1419 | SB1-F-21 | 72 | 0.663926023368 | -0.4674 | 0.6317 | 0.8296 | -0.3694 | 2.4827 |
| Hs 578T | Pevonedistat | 72 | 0.250318851881 | -0.1834 | 0.6322 | 0.2775 | -0.0801 | 1.4401 |
| SK-BR-3 | HBX 41108 | 72 | 0.707551662904 | -0.6033 | 0.6328 | 2.3097 | -0.7141 | 0.7499 |
| MDA-MB-134-VI | HY-50736 | 72 | 1.15751643186 | -0.5688 | 0.6417 | 1.9555 | -0.5934 | 1.4920 |