Breast Cancer Deubiquitinating Enzyme (DUB) Inhibitor Profiling: Fixed-cell GR measures of 21 breast cell lines to 32 small molecule perturbagens. Dataset 2 of 2: Calculated dose response metrics. - Dataset (ID:20351)
Download: Excel (XLSX), Comma-separated (CSV)
| Cell | Small Molecule | Treatment Duration | GR50 | GRmax | GR_AOC | GEC50 | GRinf | hGR |
|---|---|---|---|---|---|---|---|---|
| MCF7 | z-VAE(OMe)-fmk | 72 | inf | 1.0118 | -0.0177 | 0.0000 | 1.0000 | 0.0100 |
| HCC1937 | GW7647 | 72 | inf | 0.8246 | -0.0146 | 0.0000 | 0.9883 | 0.0100 |
| HCC1937 | z-VAE(OMe)-fmk | 72 | inf | 0.9933 | -0.0106 | 0.0000 | 1.0000 | 0.0100 |
| MCF7 | GW7647 | 72 | 67.0602654387 | 0.8376 | -0.0104 | 77.7420 | -0.5174 | 4.8064 |
| MCF7 | STK547622 | 72 | inf | 1.0181 | -0.0093 | 0.0000 | 1.0000 | 0.0100 |
| MCF7 | 5-(4-fluorophenyl)-3-hydroxy-4-(5-methyl-2-furoyl)-1-(3-pyridinylmethyl)-1,5-dihydro-2H-pyrrol-2-one | 72 | inf | 1.0084 | -0.0062 | 0.0000 | 1.0000 | 0.0100 |
| HCC1419 | 5-(4-fluorophenyl)-3-hydroxy-4-(5-methyl-2-furoyl)-1-(3-pyridinylmethyl)-1,5-dihydro-2H-pyrrol-2-one | 72 | inf | 0.9816 | -0.0058 | 0.0000 | 1.0000 | 0.0100 |
| MCF 10A | STK547622 | 72 | inf | 1.0022 | -0.0053 | 0.0000 | 1.0000 | 0.0100 |
| HCC1937 | 5-(4-fluorophenyl)-3-hydroxy-4-(5-methyl-2-furoyl)-1-(3-pyridinylmethyl)-1,5-dihydro-2H-pyrrol-2-one | 72 | inf | 0.9970 | -0.0035 | 0.0000 | 1.0000 | 0.0100 |
| HCC1937 | USP7-IN-1 | 72 | 65.8738738326 | 0.8119 | -0.0032 | 83.7971 | -0.9000 | 4.2784 |
| MDA-MB-231 | STK547622 | 72 | inf | 0.9830 | -0.0027 | 0.0000 | 1.0000 | 0.0100 |
| HCC1428 | GW7647 | 72 | inf | 0.6988 | -0.0012 | 0.0000 | 0.9685 | 0.0100 |
| MDA-MB-361 | GW7647 | 72 | inf | 0.9669 | -0.0010 | 0.0000 | 0.9993 | 0.0100 |
| MDA-MB-231 | Spautin-1 | 72 | inf | 0.8635 | 0.0004 | 0.0000 | 0.9855 | 0.0100 |
| Hs 578T | USP7-IN-1 | 72 | inf | 0.8486 | 0.0005 | 0.0000 | 0.9854 | 0.0100 |
| MCF 10A | z-VAE(OMe)-fmk | 72 | inf | 0.9979 | 0.0012 | 0.0000 | 0.9999 | 0.0100 |
| HCC1500 | 5-(4-fluorophenyl)-3-hydroxy-4-(5-methyl-2-furoyl)-1-(3-pyridinylmethyl)-1,5-dihydro-2H-pyrrol-2-one | 72 | inf | 1.0783 | 0.0024 | 0.0000 | 0.9998 | 0.0100 |
| MDA-MB-231 | z-VAE(OMe)-fmk | 72 | inf | 0.9382 | 0.0024 | 0.0000 | 0.9922 | 0.0100 |
| PDXHCI002 | HY-17542 | 72 | inf | 0.9564 | 0.0027 | 0.0000 | 0.9920 | 0.0100 |
| HCC1954 | HY-17542 | 72 | inf | 0.9541 | 0.0043 | 0.0000 | 0.9888 | 0.0100 |
| PDX1328 | HY-17542 | 72 | inf | 0.7180 | 0.0045 | 0.0000 | 0.9630 | 0.0100 |
| HCC1806 | IU1 | 72 | 116.251943958 | 0.8831 | 0.0051 | 197.1530 | -0.9493 | 2.0147 |
| BT-549 | STK547622 | 72 | inf | 0.9826 | 0.0068 | 0.0000 | 0.9966 | 0.0100 |
| MCF7 | HY-17542 | 72 | inf | 0.9160 | 0.0071 | 30.5166 | 0.9088 | 5.0000 |
| HCC1419 | GW7647 | 72 | 39.4857944397 | -0.0439 | 0.0074 | 49.1887 | -1.0000 | 5.0000 |