Breast Cancer Deubiquitinating Enzyme (DUB) Inhibitor Profiling: Fixed-cell GR measures of 21 breast cell lines to 32 small molecule perturbagens. Dataset 2 of 2: Calculated dose response metrics. - Dataset (ID:20351)
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| Cell | Small Molecule | Treatment Duration | GR50 | GRmax | GR_AOC | GEC50 | GRinf | hGR |
|---|---|---|---|---|---|---|---|---|
| SK-BR-3 | Trifluoperazine | 72 | 8.87780846384 | -0.7359 | 0.3201 | 12.7153 | -0.8135 | 2.6884 |
| CAMA-1 | Pimozide | 72 | 10.5638318882 | -0.6260 | 0.3203 | 12.3722 | -0.6018 | 5.0000 |
| T47D | LDN57444 | 72 | 5.98029149748 | -0.4896 | 0.3206 | 18.7611 | -0.9206 | 0.9133 |
| T47D | HY-17541A | 72 | 6.09725713645 | -0.5568 | 0.3223 | 17.5481 | -1.0000 | 1.0393 |
| Hs 578T | Trifluoperazine | 72 | 8.05469083899 | -0.4570 | 0.3243 | 10.8580 | -0.5129 | 2.3639 |
| PDX1328 | P22077 | 72 | 8.67568163015 | -0.9510 | 0.3247 | 12.1205 | -0.9858 | 3.2572 |
| MDA-MB-134-VI | HY-50737A | 72 | 5.9031368352 | -0.5171 | 0.3304 | 19.3421 | -0.9632 | 0.9048 |
| SK-BR-3 | PB49673382 | 72 | 4.13146034734 | 0.0664 | 0.3312 | 3.9132 | 0.0565 | 2.2078 |
| BT-20 | HY-17541A | 72 | 9.75522426236 | -0.8815 | 0.3328 | 13.7782 | -0.9458 | 3.0751 |
| CAMA-1 | Trifluoperazine | 72 | 8.45406954344 | -0.6457 | 0.3334 | 11.8787 | -0.7033 | 2.5823 |
| MDA-MB-134-VI | Trifluoperazine | 72 | 9.80158936254 | -0.8785 | 0.3335 | 11.9699 | -0.8413 | 4.9377 |
| MDA-MB-134-VI | Spautin-1 | 72 | 6.41375749525 | -0.2188 | 0.3340 | 7.1071 | -0.1453 | 2.4851 |
| PDX1258 | Trifluoperazine | 72 | 9.06336153073 | -0.6331 | 0.3343 | 13.1356 | -0.7329 | 2.4320 |
| SK-BR-3 | HY-17541A | 72 | 6.05256867179 | -0.8127 | 0.3348 | 15.3356 | -1.0000 | 1.1817 |
| T47D | PB49673382 | 72 | 3.64102000587 | -0.0634 | 0.3384 | 3.7853 | -0.0626 | 3.0337 |
| MCF 10A | P22077 | 72 | 4.7951144345 | -0.3461 | 0.3384 | 5.2700 | -0.2789 | 4.6944 |
| HCC1428 | 1247825-37-1 | 72 | 4.93495492588 | -0.2477 | 0.3384 | 6.4761 | -0.2632 | 1.5561 |
| SK-BR-3 | P22077 | 72 | 7.32594313781 | -0.7339 | 0.3405 | 11.7189 | -0.8571 | 2.1255 |
| MDA-MB-361 | Trifluoperazine | 72 | 9.45447519759 | -0.7673 | 0.3443 | 11.3498 | -0.7466 | 5.0000 |
| PDXHCI002 | HY-17541A | 72 | 5.47225294247 | -0.5597 | 0.3450 | 15.9936 | -1.0000 | 1.0243 |
| MDA-MB-361 | SJB2-043 | 72 | 1.59047305005 | -0.2559 | 0.3538 | 1.7814 | -0.2365 | 3.4159 |
| CAMA-1 | PB49673382 | 72 | 3.4845103029 | -0.0579 | 0.3546 | 3.6236 | -0.0592 | 2.8598 |
| PDX1328 | Vialinin A | 72 | 6.5234902309 | -0.8259 | 0.3553 | 12.0354 | -0.9870 | 1.7796 |
| PDX1328 | HY-17541A | 72 | 6.04754155289 | -0.9724 | 0.3564 | 13.0481 | -1.0000 | 1.4286 |
| T47D | Pimozide | 72 | 7.11853496187 | -0.5532 | 0.3575 | 16.3429 | -1.0000 | 1.3219 |