Breast Cancer Deubiquitinating Enzyme (DUB) Inhibitor Profiling: Fixed-cell GR measures of 21 breast cell lines to 32 small molecule perturbagens. Dataset 2 of 2: Calculated dose response metrics. - Dataset (ID:20351)
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| Cell | Small Molecule | Treatment Duration | GR50 | GRmax | GR_AOC | GEC50 | GRinf | hGR |
|---|---|---|---|---|---|---|---|---|
| HCC1806 | Trifluoperazine | 72 | 10.9947833372 | -0.4718 | 0.2306 | 13.1239 | -0.4829 | 3.8183 |
| HCC1806 | PB49673382 | 72 | 6.71137786447 | 0.1357 | 0.2326 | 5.6599 | 0.1234 | 1.6630 |
| HCC202 | Vialinin A | 72 | 7.85110394178 | -0.4245 | 0.2333 | 14.2814 | -0.5846 | 1.2943 |
| CAMA-1 | Spautin-1 | 72 | 8.38966554919 | 0.1933 | 0.2334 | 6.6491 | 0.1026 | 0.9877 |
| Hs 578T | P22077 | 72 | 9.90749185438 | -0.5101 | 0.2336 | 15.3845 | -0.6793 | 1.9498 |
| PDXHCI002 | 1247825-37-1 | 72 | 7.7918126167 | -0.2501 | 0.2337 | 8.8742 | -0.2609 | 3.2282 |
| HCC202 | PB49673382 | 72 | 5.94545205071 | 0.0754 | 0.2337 | 5.4906 | 0.1376 | 4.0443 |
| MCF 10A | 1247825-37-1 | 72 | 7.50677192458 | -0.0271 | 0.2339 | 7.8926 | -0.0577 | 2.1809 |
| HCC1806 | Vialinin A | 72 | 10.1468204153 | -0.3590 | 0.2361 | 11.8590 | -0.3766 | 3.6003 |
| HCC1428 | LDN57444 | 72 | 12.549009736 | -0.0136 | 0.2378 | 89.8320 | -1.0000 | 0.5582 |
| HCC1419 | Spautin-1 | 72 | 4.87236648112 | 0.2290 | 0.2386 | 3.5270 | 0.2325 | 1.9354 |
| T47D | Spautin-1 | 72 | 6.81498097187 | 0.2682 | 0.2402 | 3.7541 | 0.2153 | 0.9443 |
| HCC1806 | P22077 | 72 | 10.1999122294 | -0.4514 | 0.2415 | 13.5370 | -0.5064 | 2.4715 |
| HCC1500 | 1247825-37-1 | 72 | 9.28838157031 | -0.3852 | 0.2439 | 10.3909 | -0.3761 | 5.0000 |
| Hs 578T | HBX19818 | 72 | 11.9910919139 | -0.5368 | 0.2444 | 15.5278 | -0.5808 | 2.9824 |
| HCC1428 | HBX19818 | 72 | 11.3560823948 | -0.6631 | 0.2445 | 21.0348 | -1.0000 | 1.7822 |
| PDXHCI002 | P22077 | 72 | 10.7479118489 | -0.5061 | 0.2448 | 17.0137 | -0.7180 | 1.9385 |
| BT-549 | Pimozide | 72 | 12.900272139 | -0.4203 | 0.2457 | 17.3340 | -0.5372 | 2.4698 |
| MDA-MB-361 | Pimozide | 72 | 12.9023293957 | -0.6485 | 0.2470 | 22.5246 | -1.0000 | 1.9717 |
| HCC1806 | 1247825-37-1 | 72 | 9.12829214245 | -0.2678 | 0.2475 | 11.9984 | -0.3697 | 2.0245 |
| PDX1258 | PB49673382 | 72 | 5.45211284753 | 0.1759 | 0.2476 | 5.0473 | 0.1600 | 5.0000 |
| HCC1419 | PB49673382 | 72 | 5.75380160264 | 0.0084 | 0.2491 | 5.7215 | 0.0090 | 3.2180 |
| HCC1419 | P22077 | 72 | 8.76132440873 | -0.6824 | 0.2499 | 11.6302 | -0.7166 | 3.1394 |
| HCC1937 | Vialinin A | 72 | 8.32590505669 | -0.2754 | 0.2500 | 10.0381 | -0.2833 | 2.4000 |
| HCC1954 | Pimozide | 72 | 10.6179238171 | -0.3320 | 0.2520 | 12.4471 | -0.3629 | 3.4336 |