Breast Cancer Deubiquitinating Enzyme (DUB) Inhibitor Profiling: Fixed-cell GR measures of 21 breast cell lines to 32 small molecule perturbagens. Dataset 2 of 2: Calculated dose response metrics. - Dataset (ID:20351)
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| Cell | Small Molecule | Treatment Duration | GR50 | GRmax | GR_AOC | GEC50 | GRinf | hGR |
|---|---|---|---|---|---|---|---|---|
| SK-BR-3 | HBX19818 | 72 | 16.5240512414 | -0.5295 | 0.1906 | 30.2429 | -1.0000 | 1.8176 |
| BT-549 | HY-17541A | 72 | 16.8403527969 | -0.5863 | 0.1928 | 28.1688 | -1.0000 | 2.1356 |
| MDA-MB-231 | P22077 | 72 | 14.6624018854 | -0.4168 | 0.1929 | 17.8309 | -0.4659 | 3.3658 |
| MCF 10A | Doxycycline | 72 | 17.5607328555 | 0.0611 | 0.1936 | 17.6072 | -0.0035 | 2.6522 |
| HCC1500 | Doxycycline | 72 | 22.0862589106 | -0.3863 | 0.1938 | 36.1548 | -1.0000 | 2.2291 |
| HCC202 | HBX19818 | 72 | 15.8528818617 | -0.3562 | 0.1986 | 34.9884 | -1.0000 | 1.3877 |
| T47D | ML-323 | 72 | 13.4276900688 | 0.0649 | 0.2011 | 60.0348 | -0.9911 | 0.7296 |
| BT-549 | Trifluoperazine | 72 | 15.935091597 | -0.6252 | 0.2021 | 21.7254 | -0.7609 | 2.9843 |
| MDA-MB-134-VI | 1247825-37-1 | 72 | 10.4154396199 | -0.1095 | 0.2026 | 10.7700 | -0.0911 | 5.0000 |
| MCF 10A | Trifluoperazine | 72 | 13.7054527208 | -0.3753 | 0.2032 | 15.3336 | -0.3764 | 5.0000 |
| PDXHCI002 | HY-50737A | 72 | 11.4596842357 | -0.3785 | 0.2045 | 23.6412 | -0.8333 | 1.3544 |
| HCC1500 | SB1-F-22 | 72 | 8.98637669492 | 0.0425 | 0.2068 | 10.2676 | -0.0717 | 1.0048 |
| MCF7 | P22077 | 72 | 10.7385958579 | -0.3409 | 0.2082 | 11.8606 | -0.3218 | 5.0000 |
| MDA-MB-361 | Spautin-1 | 72 | 6.94135435106 | -0.1974 | 0.2123 | 7.5347 | -0.1634 | 3.4474 |
| MCF7 | Trifluoperazine | 72 | 11.3097883651 | -0.4096 | 0.2127 | 13.2613 | -0.4283 | 3.8867 |
| HCC1937 | PB49673382 | 72 | 7.51602525958 | 0.2509 | 0.2135 | 5.4225 | 0.2446 | 2.0574 |
| HCC1500 | HBX19818 | 72 | 15.1685808671 | -0.6194 | 0.2142 | 22.6040 | -0.8501 | 2.4902 |
| HCC1806 | HY-50737A | 72 | 11.8311020156 | -0.2747 | 0.2199 | 12.8932 | -0.2685 | 5.0000 |
| MCF7 | Pimozide | 72 | 12.3412443971 | -0.3107 | 0.2210 | 14.3123 | -0.3385 | 3.4890 |
| HCC1806 | Pimozide | 72 | 11.3348298234 | -0.4227 | 0.2230 | 12.8256 | -0.4274 | 5.0000 |
| T47D | Doxycycline | 72 | 15.8755936591 | -0.2262 | 0.2230 | 24.9860 | -0.5704 | 1.6784 |
| MDA-MB-361 | Vialinin A | 72 | 7.75271686789 | -0.4045 | 0.2275 | 8.9559 | -0.3189 | 3.4198 |
| HCC1937 | Pimozide | 72 | 14.4705530938 | -0.3172 | 0.2285 | 17.9899 | -0.4074 | 2.7377 |
| BT-549 | Vialinin A | 72 | 10.2995235466 | -0.3417 | 0.2294 | 12.2594 | -0.3642 | 3.1415 |
| HCC1806 | Trifluoperazine | 72 | 10.9947833372 | -0.4718 | 0.2306 | 13.1239 | -0.4829 | 3.8183 |