Breast Cancer Deubiquitinating Enzyme (DUB) Inhibitor Profiling: Fixed-cell GR measures of 21 breast cell lines to 32 small molecule perturbagens. Dataset 2 of 2: Calculated dose response metrics. - Dataset (ID:20351)
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| Cell | Small Molecule | Treatment Duration | GR50 | GRmax | GR_AOC | GEC50 | GRinf | hGR |
|---|---|---|---|---|---|---|---|---|
| HCC1806 | Doxycycline | 72 | 17.2474618301 | -0.1768 | 0.1626 | 21.2744 | -0.3287 | 2.4080 |
| CAMA-1 | 1247825-37-1 | 72 | 12.5263467336 | -0.2434 | 0.1646 | 13.4850 | -0.2229 | 5.0000 |
| MDA-MB-361 | 1247825-37-1 | 72 | 13.2255127818 | -0.4648 | 0.1648 | 21.0813 | -0.7304 | 1.9314 |
| Hs 578T | LDN57444 | 72 | 19.4934085155 | -0.0884 | 0.1662 | 33.0205 | -0.6495 | 1.5795 |
| HCC1419 | 1247825-37-1 | 72 | 11.9633348293 | -0.2267 | 0.1675 | 13.1469 | -0.2174 | 3.8271 |
| Hs 578T | PB49673382 | 72 | 9.65679731349 | 0.0485 | 0.1681 | 9.2758 | 0.0479 | 2.5005 |
| CAMA-1 | Doxycycline | 72 | 20.1165363681 | -0.1002 | 0.1702 | 44.6977 | -1.0000 | 1.3761 |
| BT-20 | 1247825-37-1 | 72 | 10.843923028 | -0.5078 | 0.1707 | 13.0472 | -0.4829 | 3.6541 |
| T47D | HBX19818 | 72 | 19.8447349854 | -0.2828 | 0.1712 | 37.7631 | -1.0000 | 1.7075 |
| MCF 10A | Pimozide | 72 | 16.0216158403 | -0.1385 | 0.1713 | 17.8369 | -0.1921 | 3.0288 |
| BT-549 | Doxycycline | 72 | 16.3310783662 | -0.1425 | 0.1726 | 19.1261 | -0.2467 | 2.5386 |
| MCF 10A | Vialinin A | 72 | 12.7930209016 | -0.2051 | 0.1740 | 13.7221 | -0.2088 | 4.9768 |
| MDA-MB-134-VI | HBX19818 | 72 | 16.8677883349 | -0.7570 | 0.1742 | 25.9920 | -1.0000 | 2.5408 |
| MDA-MB-134-VI | IU1 | 72 | inf | 0.5672 | 0.1770 | 1.5029 | 0.5472 | 5.0000 |
| MCF7 | 1247825-37-1 | 72 | 11.3527817708 | -0.0635 | 0.1793 | 13.0348 | -0.1527 | 1.9288 |
| SK-BR-3 | LDN57444 | 72 | 22.3408232354 | 0.2285 | 0.1807 | 104.9983 | -1.0000 | 0.7099 |
| MDA-MB-231 | 1247825-37-1 | 72 | 11.4936019115 | -0.0918 | 0.1830 | 11.8477 | -0.0819 | 5.0000 |
| HCC1954 | LDN57444 | 72 | 18.837326116 | 0.0230 | 0.1849 | 56.1555 | -1.0000 | 1.0058 |
| HCC202 | 1247825-37-1 | 72 | 8.82600510672 | -0.3858 | 0.1854 | 10.8343 | -0.3618 | 2.6557 |
| MDA-MB-231 | HBX19818 | 72 | 17.6158530759 | -0.6695 | 0.1856 | 28.5232 | -0.9794 | 2.2510 |
| PDXHCI002 | ML-323 | 72 | 17.8247031142 | 0.1781 | 0.1858 | 109.9820 | -1.0000 | 0.6037 |
| MDA-MB-231 | PB49673382 | 72 | 8.96593855475 | -0.0627 | 0.1864 | 9.0711 | -0.0300 | 5.0000 |
| MCF 10A | HY-17541A | 72 | 17.9688754214 | -0.3960 | 0.1869 | 23.8178 | -0.5829 | 2.7426 |
| MDA-MB-134-VI | 5-(4-fluorophenyl)-3-hydroxy-4-(5-methyl-2-furoyl)-1-(3-pyridinylmethyl)-1,5-dihydro-2H-pyrrol-2-one | 72 | inf | 1.1199 | 0.1894 | 0.0000 | 0.8466 | 0.0100 |
| T47D | 1247825-37-1 | 72 | 11.5296139364 | -0.2221 | 0.1900 | 12.3560 | -0.2068 | 5.0000 |