Breast Cancer Deubiquitinating Enzyme (DUB) Inhibitor Profiling: Fixed-cell GR measures of 21 breast cell lines to 32 small molecule perturbagens. Dataset 2 of 2: Calculated dose response metrics. - Dataset (ID:20351)
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| Cell | Small Molecule | Treatment Duration | GR50 | GRmax | GR_AOC | GEC50 | GRinf | hGR |
|---|---|---|---|---|---|---|---|---|
| BT-549 | HY-50736 | 72 | 0.0483582820394 | -0.3009 | 1.0550 | 0.0658 | -0.3461 | 1.7080 |
| T47D | Pevonedistat | 72 | 0.0485963385259 | -0.0543 | 0.9154 | 0.0536 | -0.1256 | 2.2893 |
| HCC1419 | HY-50736 | 72 | 0.0489088737336 | -0.6741 | 1.2774 | 0.0889 | -0.7080 | 1.4773 |
| HCC1428 | Pevonedistat | 72 | 0.0551476845561 | -0.1563 | 0.9412 | 0.0662 | -0.1995 | 1.8358 |
| MDA-MB-134-VI | Pevonedistat | 72 | 0.0632002423546 | -0.2210 | 0.8831 | 0.0747 | -0.1673 | 1.7325 |
| HCC1428 | b-AP15 | 72 | 0.0647974209893 | -0.7164 | 1.1058 | 0.1041 | -0.5730 | 1.6094 |
| SK-BR-3 | b-AP15 | 72 | 0.0708405930018 | -0.6425 | 1.0904 | 0.1445 | -0.6152 | 1.1256 |
| HCC1954 | b-AP15 | 72 | 0.0709214214205 | -0.7172 | 1.2064 | 0.1119 | -0.6936 | 1.9069 |
| HCC1428 | HBX 41108 | 72 | 0.0712282775341 | -0.6506 | 1.0708 | 0.1364 | -0.5624 | 1.1606 |
| HCC1419 | Sepantronium | 72 | 0.0796965605305 | -0.7110 | 1.1081 | 0.1781 | -0.6956 | 1.0840 |
| HCC1954 | HY-50736 | 72 | 0.0820968061449 | -0.4069 | 1.1010 | 0.1207 | -0.5219 | 1.8530 |
| PDXHCI002 | Sepantronium | 72 | 0.0830755783448 | -0.5798 | 1.0081 | 0.1289 | -0.4748 | 1.5187 |
| SK-BR-3 | Pevonedistat | 72 | 0.0849225267347 | 0.0282 | 0.7128 | 0.0790 | 0.0487 | 1.4169 |
| HCC1937 | Pevonedistat | 72 | 0.0855702491458 | -0.1081 | 0.7701 | 0.0915 | -0.0540 | 1.5279 |
| Hs 578T | b-AP15 | 72 | 0.0926975330711 | -0.5434 | 1.0259 | 0.1069 | -0.4418 | 4.4499 |
| PDX1258 | Sepantronium | 72 | 0.0944990954 | -0.5758 | 0.9903 | 0.1955 | -0.5482 | 1.0184 |
| HCC1937 | HY-50737A | 72 | 0.0985106934226 | -0.4932 | 0.9863 | 0.1784 | -0.5076 | 1.1795 |
| HCC202 | b-AP15 | 72 | 0.101469191263 | -0.7256 | 1.0819 | 0.1809 | -0.6658 | 1.4645 |
| MDA-MB-361 | Pevonedistat | 72 | 0.105133263812 | -0.3279 | 0.8618 | 0.1270 | -0.2800 | 2.3487 |
| MDA-MB-361 | b-AP15 | 72 | 0.109447404861 | -0.6928 | 1.0525 | 0.1830 | -0.6219 | 1.5720 |
| Hs 578T | Sepantronium | 72 | 0.111331714329 | -0.4992 | 0.9039 | 0.2765 | -0.5106 | 0.7735 |
| HCC1500 | SJB3-019A | 72 | 0.111463571386 | -0.5985 | 1.0350 | 0.1889 | -0.5857 | 1.4704 |
| HCC1500 | HY-50737A | 72 | 0.114212661737 | -0.5828 | 1.0742 | 0.1811 | -0.6211 | 1.7514 |
| SK-BR-3 | HY-50736 | 72 | 0.115680810144 | -0.4176 | 0.9862 | 0.1504 | -0.4466 | 2.4308 |
| PDX1328 | SJB3-019A | 72 | 0.117013699533 | -0.9745 | 1.3027 | 0.1897 | -0.9715 | 2.2348 |