Breast Cancer Deubiquitinating Enzyme (DUB) Inhibitor Profiling: Fixed-cell GR measures of 21 breast cell lines to 32 small molecule perturbagens. Dataset 2 of 2: Calculated dose response metrics. - Dataset (ID:20351)

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Cell Small Molecule Treatment Duration GR50 GRmax GR_AOC GEC50 GRinf hGR
BT-20 HY-17542 72
inf
 1.0099 -0.0181 0.0000 1.0000 0.0100
HCC202 IU1 72
inf
 0.7641 -0.0242 0.0000 0.9954 0.0100
HCC1937 Spautin-1 72
inf
 0.6302 0.0761 13.9030 0.5336 0.8715
T47D STK547622 72
inf
 0.9428 0.0182 0.0000 0.9914 0.0100
HCC1937 z-VAE(OMe)-fmk 72
inf
 0.9933 -0.0106 0.0000 1.0000 0.0100
HCC202 GW7647 72
inf
 0.8031 -0.0688 0.0000 1.0000 0.0100
BT-20 GW7647 72
inf
 0.7093 -0.0625 0.0000 1.0000 0.0100
HCC202 USP7-IN-1 72
inf
 0.8501 -0.0200 0.0000 1.0000 0.0100
HCC1954 z-VAE(OMe)-fmk 72
inf
 1.0513 0.0385 0.0000 0.9751 0.0100
HCC1954 USP7-IN-1 72
inf
 0.8323 0.0313 0.0000 0.9524 0.0100
HCC1954 HY-17542 72
inf
 0.9541 0.0043 0.0000 0.9888 0.0100
HCC1954 STK547622 72
inf
 0.8996 0.0165 0.0000 0.9826 0.0100
HCC1954 IU1 72
inf
 0.7969 0.0254 8.5142 0.7979 1.8182
HCC1954 5-(4-fluorophenyl)-3-hydroxy-4-(5-methyl-2-furoyl)-1-(3-pyridinylmethyl)-1,5-dihydro-2H-pyrrol-2-one 72
inf
 0.8537 0.0553 0.0000 0.9409 0.0100
T47D z-VAE(OMe)-fmk 72
inf
 0.9468 0.0261 0.0000 0.9749 0.0100
MDA-MB-361 z-VAE(OMe)-fmk 72
inf
 0.9096 0.0284 0.0000 0.9738 0.0100
HCC1419 IU1 72
inf
 0.6981 0.0438 17.0535 0.7480 5.0000
PDX1258 USP7-IN-1 72
inf
 0.8007 0.0688 0.0000 0.9245 0.0100
PDX1258 GW7647 72
inf
 1.0702 -0.0651 0.0000 1.0000 0.0100
MDA-MB-361 Doxycycline 72
inf
 0.9696 0.0534 0.0000 0.9201 0.0100
HCC1419 HY-17542 72
inf
 0.8046 0.0234 7.3179 0.8511 5.0000
MDA-MB-361 STK547622 72
inf
 1.0471 -0.1279 0.0000 1.0000 0.0100