Breast Cancer Deubiquitinating Enzyme (DUB) Inhibitor Profiling: Fixed-cell GR measures of 21 breast cell lines to 32 small molecule perturbagens. Dataset 2 of 2: Calculated dose response metrics. - Dataset (ID:20351)
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| Cell | Small Molecule | Treatment Duration | GR50 | GRmax | GR_AOC | GEC50 | GRinf | hGR |
|---|---|---|---|---|---|---|---|---|
| HCC1419 | USP7-IN-1 | 72 | 44.7550079567 | 0.4088 | 0.0472 | 76.1826 | -1.0000 | 2.0653 |
| MDA-MB-134-VI | ML-323 | 72 | 45.5586104943 | 0.3266 | 0.0626 | 58.1271 | -1.0000 | 4.5093 |
| BT-549 | PB49673382 | 72 | 4.76901821965 | -0.0004 | 0.2990 | 4.7981 | -0.0079 | 2.5928 |
| MCF 10A | P22077 | 72 | 4.7951144345 | -0.3461 | 0.3384 | 5.2700 | -0.2789 | 4.6944 |
| Hs 578T | SB1-F-22 | 72 | 48.629206693 | 0.4746 | 0.0557 | 108.1899 | -1.0000 | 1.3738 |
| HCC1419 | Spautin-1 | 72 | 4.87236648112 | 0.2290 | 0.2386 | 3.5270 | 0.2325 | 1.9354 |
| PDX1258 | HY-17541A | 72 | 4.88569792161 | -0.6381 | 0.3717 | 13.5459 | -1.0000 | 1.0773 |
| HCC1428 | 1247825-37-1 | 72 | 4.93495492588 | -0.2477 | 0.3384 | 6.4761 | -0.2632 | 1.5561 |
| MDA-MB-231 | LDN57444 | 72 | 4.94637461912 | -0.0113 | 0.2894 | 4.9647 | -0.0024 | 1.2750 |
| PDX1258 | Pimozide | 72 | 5.06894491311 | -0.3597 | 0.3871 | 19.1221 | -1.0000 | 0.8274 |
| HCC1419 | HY-17541A | 72 | 5.08410753288 | -0.7228 | 0.3771 | 13.2847 | -1.0000 | 1.1438 |
| BT-20 | Vialinin A | 72 | 5.11668603811 | -0.6101 | 0.3004 | 9.2727 | -0.7177 | 1.4971 |
| CAMA-1 | GW7647 | 72 | 51.1807184271 | 0.5179 | 0.0238 | 80.0691 | -0.9662 | 2.4039 |
| HCC1806 | ML-323 | 72 | 51.7025090437 | 0.5104 | 0.0851 | 100.5354 | -0.3756 | 0.8426 |
| HCC1500 | USP7-IN-1 | 72 | 51.9923039456 | 0.4861 | 0.0630 | 130.5080 | -1.0000 | 1.1937 |
| SK-BR-3 | Spautin-1 | 72 | 52.4840202993 | 0.5136 | 0.1207 | 9.4550 | 0.4402 | 1.2389 |
| PDX1328 | MI-2 | 72 | 5.25760821785 | -0.9161 | 0.4330 | 6.4858 | -0.9284 | 5.0000 |
| HCC1954 | GW7647 | 72 | 53.2192077737 | 0.5700 | -0.0367 | 66.2968 | -1.0000 | 5.0000 |
| Hs 578T | Vialinin A | 72 | 5.33738832012 | -0.3425 | 0.2871 | 8.1284 | -0.4124 | 1.4299 |
| MCF 10A | PB49673382 | 72 | 5.3905505782 | 0.0428 | 0.2622 | 5.1937 | 0.0339 | 1.8897 |
| PDX1258 | PB49673382 | 72 | 5.45211284753 | 0.1759 | 0.2476 | 5.0473 | 0.1600 | 5.0000 |
| PDXHCI002 | HY-17541A | 72 | 5.47225294247 | -0.5597 | 0.3450 | 15.9936 | -1.0000 | 1.0243 |
| HCC1428 | Pimozide | 72 | 5.48832397235 | -0.7126 | 0.4005 | 12.0349 | -1.0000 | 1.3992 |
| MDA-MB-134-VI | Degrasyn | 72 | 5.55416643616 | -0.7023 | 0.4475 | 6.5896 | -0.6754 | 5.0000 |
| T47D | Vialinin A | 72 | 5.62945811704 | -0.3676 | 0.2949 | 7.5227 | -0.3834 | 1.9635 |