Breast Cancer Deubiquitinating Enzyme (DUB) Inhibitor Profiling: Fixed-cell GR measures of 21 breast cell lines to 32 small molecule perturbagens. Dataset 2 of 2: Calculated dose response metrics. - Dataset (ID:20351)
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| Cell | Small Molecule | Treatment Duration | GR50 | GRmax | GR_AOC | GEC50 | GRinf | hGR |
|---|---|---|---|---|---|---|---|---|
| SK-BR-3 | HY-50737A | 72 | 0.478741799562 | -0.5895 | 0.7685 | 0.6829 | -0.5240 | 2.0185 |
| MDA-MB-231 | MI-2 | 72 | 0.537364787333 | -0.5738 | 0.7460 | 0.7155 | -0.5046 | 2.4370 |
| HCC1428 | SB1-F-21 | 72 | 0.390716798135 | -0.7458 | 0.8486 | 0.7302 | -0.7362 | 1.4476 |
| BT-549 | HBX 41108 | 72 | 0.419436290406 | -0.3090 | 0.6569 | 0.7538 | -0.3407 | 0.8863 |
| CAMA-1 | SB1-F-21 | 72 | 0.356288555928 | -0.6495 | 0.7890 | 0.7680 | -0.6356 | 1.0680 |
| MCF7 | SB1-F-21 | 72 | 0.615140979311 | -0.3940 | 0.6577 | 0.7749 | -0.3444 | 2.2705 |
| HCC1954 | SB1-F-21 | 72 | 0.554362808497 | -0.7800 | 0.7854 | 0.7812 | -0.6692 | 2.4761 |
| BT-20 | SJB2-043 | 72 | 0.626589137637 | -0.6216 | 0.5257 | 0.7914 | -0.6048 | 3.3941 |
| MCF 10A | HY-50736 | 72 | 0.719497257196 | -0.1011 | 0.5489 | 0.7937 | -0.1109 | 2.0414 |
| MDA-MB-361 | SJB3-019A | 72 | 0.668312775117 | -0.7320 | 0.8218 | 0.7953 | -0.6795 | 4.9328 |
| Hs 578T | SB1-F-21 | 72 | 0.452409395258 | -0.5167 | 0.7097 | 0.8042 | -0.4961 | 1.1980 |
| MDA-MB-361 | SB1-F-21 | 72 | 0.683787272085 | -0.7860 | 0.7684 | 0.8135 | -0.6777 | 4.9337 |
| BT-20 | SB1-F-21 | 72 | 0.696988451088 | -0.7116 | 0.7843 | 0.8263 | -0.6712 | 5.0000 |
| HCC1419 | SB1-F-21 | 72 | 0.663926023368 | -0.4674 | 0.6317 | 0.8296 | -0.3694 | 2.4827 |
| PDX1328 | HBX 41108 | 72 | 0.252282958678 | -0.8598 | 0.9493 | 0.8725 | -0.9529 | 0.8597 |
| PDXHCI002 | SJB2-043 | 72 | 0.744329070426 | -0.3405 | 0.5118 | 0.9155 | -0.3386 | 2.4985 |
| CAMA-1 | IU1 | 72 | inf | 0.7385 | 0.0833 | 0.9170 | 0.8015 | 5.0000 |
| HCC1500 | Sepantronium | 72 | 0.48222369882 | -0.6675 | 0.7593 | 0.9213 | -0.6468 | 1.2822 |
| T47D | HY-50736 | 72 | 0.739108069654 | -0.3225 | 0.6531 | 0.9282 | -0.3566 | 2.3631 |
| MCF 10A | SJB2-043 | 72 | 0.862612545381 | -0.1149 | 0.4174 | 0.9321 | -0.1040 | 2.4388 |
| BT-20 | HY-50737A | 72 | 0.556969018793 | -0.5469 | 0.6980 | 0.9349 | -0.5102 | 1.3577 |
| HCC202 | SB1-F-21 | 72 | 0.441545872924 | -0.7837 | 0.7543 | 0.9431 | -0.7246 | 1.1804 |
| PDXHCI002 | HBX 41108 | 72 | 0.569584571739 | -0.3596 | 0.6226 | 0.9572 | -0.3632 | 1.0518 |
| PDXHCI002 | SB1-F-21 | 72 | 0.621844255197 | -0.4582 | 0.6580 | 0.9577 | -0.4592 | 1.5086 |
| T47D | SB1-F-21 | 72 | 0.605682620995 | -0.5948 | 0.6994 | 0.9625 | -0.5534 | 1.6087 |