Breast Cancer Deubiquitinating Enzyme (DUB) Inhibitor Profiling: Fixed-cell GR measures of 21 breast cell lines to 32 small molecule perturbagens. Dataset 2 of 2: Calculated dose response metrics. - Dataset (ID:20351)
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| Cell | Small Molecule | Treatment Duration | GR50 | GRmax | GR_AOC | GEC50 | GRinf | hGR |
|---|---|---|---|---|---|---|---|---|
| HCC1937 | Degrasyn | 72 | 3.23543546484 | -0.4694 | 0.4319 | 3.6822 | -0.4546 | 5.0000 |
| HCC202 | LDN57444 | 72 | 35.5631753073 | 0.1261 | 0.0350 | 36.2274 | -0.0485 | 5.0000 |
| BT-20 | Pimozide | 72 | 10.6841586302 | -0.7844 | 0.2746 | 12.9223 | -0.7941 | 5.0000 |
| BT-20 | PB49673382 | 72 | 3.13374675059 | 0.0918 | 0.3024 | 2.9808 | 0.1107 | 5.0000 |
| BT-20 | Trifluoperazine | 72 | 12.3504591925 | -0.7940 | 0.2886 | 14.9777 | -0.8115 | 5.0000 |
| BT-20 | HBX19818 | 72 | 30.8921915642 | -0.2433 | 0.0631 | 35.1813 | -0.4578 | 5.0000 |
| HCC1419 | IU1 | 72 | inf | 0.6981 | 0.0438 | 17.0535 | 0.7480 | 5.0000 |
| BT-20 | SB1-F-21 | 72 | 0.696988451088 | -0.7116 | 0.7843 | 0.8263 | -0.6712 | 5.0000 |
| BT-549 | GW7647 | 72 | 38.3765494331 | 0.2776 | 0.0356 | 35.9668 | 0.1385 | 5.0000 |
| HCC1806 | Degrasyn | 72 | 2.75238625089 | -0.3101 | 0.4592 | 3.0534 | -0.3402 | 5.0000 |
| BT-549 | SJB3-019A | 72 | 0.339491273677 | -0.3726 | 0.8009 | 0.3799 | -0.3779 | 5.0000 |
| HCC1806 | Pimozide | 72 | 11.3348298234 | -0.4227 | 0.2230 | 12.8256 | -0.4274 | 5.0000 |
| CAMA-1 | IU1 | 72 | inf | 0.7385 | 0.0833 | 0.9170 | 0.8015 | 5.0000 |
| BT-20 | SJB3-019A | 72 | 0.340138717913 | -0.6009 | 0.8217 | 0.3987 | -0.6067 | 5.0000 |
| CAMA-1 | Pimozide | 72 | 10.5638318882 | -0.6260 | 0.3203 | 12.3722 | -0.6018 | 5.0000 |
| HCC1500 | 1247825-37-1 | 72 | 9.28838157031 | -0.3852 | 0.2439 | 10.3909 | -0.3761 | 5.0000 |
| HCC1954 | Degrasyn | 72 | 3.28733078255 | -0.6866 | 0.5156 | 3.9070 | -0.6857 | 5.0000 |
| HCC202 | ML-323 | 72 | inf | 0.5409 | 0.1086 | 0.9673 | 0.7036 | 5.0000 |
| HCC1419 | HY-17542 | 72 | inf | 0.8046 | 0.0234 | 7.3179 | 0.8511 | 5.0000 |
| BT-20 | Degrasyn | 72 | 1.87496854329 | -0.6371 | 0.6302 | 2.2190 | -0.6608 | 5.0000 |
| HCC1419 | GW7647 | 72 | 39.4857944397 | -0.0439 | 0.0074 | 49.1887 | -1.0000 | 5.0000 |
| BT-20 | Sepantronium | 72 | 0.00899052444777 | -0.5379 | 1.5452 | 0.0105 | -0.5979 | 5.0000 |
| HCC1954 | Doxycycline | 72 | 23.9368215941 | 0.0566 | 0.0431 | 24.0739 | -0.0145 | 5.0000 |
| PDX1258 | 1247825-37-1 | 72 | 13.2811411655 | 0.1210 | 0.0958 | 12.5137 | 0.1287 | 5.0000 |
| MDA-MB-361 | Trifluoperazine | 72 | 9.45447519759 | -0.7673 | 0.3443 | 11.3498 | -0.7466 | 5.0000 |