Breast Cancer Deubiquitinating Enzyme (DUB) Inhibitor Profiling: Fixed-cell GR measures of 21 breast cell lines to 32 small molecule perturbagens. Dataset 2 of 2: Calculated dose response metrics. - Dataset (ID:20351)
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| Cell | Small Molecule | Treatment Duration | GR50 | GRmax | GR_AOC | GEC50 | GRinf | hGR |
|---|---|---|---|---|---|---|---|---|
| MDA-MB-361 | 5-(4-fluorophenyl)-3-hydroxy-4-(5-methyl-2-furoyl)-1-(3-pyridinylmethyl)-1,5-dihydro-2H-pyrrol-2-one | 72 | inf | 1.0999 | 0.0175 | 0.0000 | 1.0000 | 0.0100 |
| BT-20 | HY-17542 | 72 | inf | 1.0099 | -0.0181 | 0.0000 | 1.0000 | 0.0100 |
| HCC1937 | z-VAE(OMe)-fmk | 72 | inf | 0.9933 | -0.0106 | 0.0000 | 1.0000 | 0.0100 |
| HCC1500 | z-VAE(OMe)-fmk | 72 | inf | 1.1021 | 0.0136 | 0.0000 | 1.0000 | 0.0100 |
| HCC1937 | HY-17542 | 72 | inf | 0.9422 | -0.0439 | 0.0000 | 1.0000 | 0.0100 |
| BT-20 | GW7647 | 72 | inf | 0.7093 | -0.0625 | 0.0000 | 1.0000 | 0.0100 |
| PDX1328 | SB1-F-22 | 72 | inf | 1.0347 | -0.2404 | 0.0000 | 1.0000 | 0.0100 |
| MCF 10A | z-VAE(OMe)-fmk | 72 | inf | 0.9979 | 0.0012 | 0.0000 | 0.9999 | 0.0100 |
| HCC1500 | 5-(4-fluorophenyl)-3-hydroxy-4-(5-methyl-2-furoyl)-1-(3-pyridinylmethyl)-1,5-dihydro-2H-pyrrol-2-one | 72 | inf | 1.0783 | 0.0024 | 0.0000 | 0.9998 | 0.0100 |
| PDXHCI002 | GW7647 | 72 | inf | 0.7629 | -0.0251 | 0.0000 | 0.9997 | 0.0100 |
| MDA-MB-361 | GW7647 | 72 | inf | 0.9669 | -0.0010 | 0.0000 | 0.9993 | 0.0100 |
| Hs 578T | 5-(4-fluorophenyl)-3-hydroxy-4-(5-methyl-2-furoyl)-1-(3-pyridinylmethyl)-1,5-dihydro-2H-pyrrol-2-one | 72 | inf | 1.0210 | 0.0119 | 0.0000 | 0.9987 | 0.0100 |
| Hs 578T | STK547622 | 72 | inf | 0.9647 | 0.0155 | 0.0000 | 0.9968 | 0.0100 |
| BT-549 | STK547622 | 72 | inf | 0.9826 | 0.0068 | 0.0000 | 0.9966 | 0.0100 |
| HCC202 | IU1 | 72 | inf | 0.7641 | -0.0242 | 0.0000 | 0.9954 | 0.0100 |
| PDX1258 | 5-(4-fluorophenyl)-3-hydroxy-4-(5-methyl-2-furoyl)-1-(3-pyridinylmethyl)-1,5-dihydro-2H-pyrrol-2-one | 72 | inf | 1.0981 | 0.0141 | 0.0000 | 0.9940 | 0.0100 |
| PDXHCI002 | STK547622 | 72 | inf | 0.9789 | 0.0218 | 0.0000 | 0.9934 | 0.0100 |
| MDA-MB-231 | z-VAE(OMe)-fmk | 72 | inf | 0.9382 | 0.0024 | 0.0000 | 0.9922 | 0.0100 |
| PDXHCI002 | HY-17542 | 72 | inf | 0.9564 | 0.0027 | 0.0000 | 0.9920 | 0.0100 |
| T47D | STK547622 | 72 | inf | 0.9428 | 0.0182 | 0.0000 | 0.9914 | 0.0100 |
| BT-20 | z-VAE(OMe)-fmk | 72 | inf | 0.9762 | 0.0198 | 0.0000 | 0.9890 | 0.0100 |
| HCC1954 | HY-17542 | 72 | inf | 0.9541 | 0.0043 | 0.0000 | 0.9888 | 0.0100 |
| PDX1328 | z-VAE(OMe)-fmk | 72 | inf | 1.0551 | 0.0297 | 0.0000 | 0.9884 | 0.0100 |
| HCC1937 | GW7647 | 72 | inf | 0.8246 | -0.0146 | 0.0000 | 0.9883 | 0.0100 |
| MDA-MB-231 | Spautin-1 | 72 | inf | 0.8635 | 0.0004 | 0.0000 | 0.9855 | 0.0100 |