Breast Cancer Deubiquitinating Enzyme (DUB) Inhibitor Profiling: Fixed-cell GR measures of 21 breast cell lines to 32 small molecule perturbagens. Dataset 2 of 2: Calculated dose response metrics. - Dataset (ID:20351)
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| Cell | Small Molecule | Treatment Duration | GR50 | GRmax | GR_AOC | GEC50 | GRinf | hGR |
|---|---|---|---|---|---|---|---|---|
| HCC1428 | HBX 41108 | 72 | 0.0712282775341 | -0.6506 | 1.0708 | 0.1364 | -0.5624 | 1.1606 |
| HCC1806 | Sepantronium | 72 | 0.0194330717839 | -0.2281 | 1.0647 | 0.0221 | -0.1914 | 2.4836 |
| HCC1419 | Mitoxantrone | 72 | 0.0324309949523 | -0.8993 | 1.0606 | 0.5551 | -1.0000 | 0.3868 |
| HCC1500 | Mitoxantrone | 72 | 0.0111833408416 | -0.4904 | 1.0596 | 0.0246 | -0.2899 | 0.5795 |
| BT-549 | HY-50736 | 72 | 0.0483582820394 | -0.3009 | 1.0550 | 0.0658 | -0.3461 | 1.7080 |
| MDA-MB-361 | b-AP15 | 72 | 0.109447404861 | -0.6928 | 1.0525 | 0.1830 | -0.6219 | 1.5720 |
| BT-20 | b-AP15 | 72 | 0.164472498608 | -0.6967 | 1.0402 | 0.2405 | -0.6510 | 2.1937 |
| CAMA-1 | HBX 41108 | 72 | 0.0470901366866 | -0.3783 | 1.0375 | 0.0808 | -0.3961 | 1.0796 |
| HCC1500 | SJB3-019A | 72 | 0.111463571386 | -0.5985 | 1.0350 | 0.1889 | -0.5857 | 1.4704 |
| HCC1806 | Pevonedistat | 72 | 0.0335529495438 | -0.2883 | 1.0267 | 0.0419 | -0.2494 | 1.8239 |
| Hs 578T | b-AP15 | 72 | 0.0926975330711 | -0.5434 | 1.0259 | 0.1069 | -0.4418 | 4.4499 |
| CAMA-1 | b-AP15 | 72 | 0.125560211136 | -0.5018 | 1.0206 | 0.1671 | -0.5285 | 2.5236 |
| SK-BR-3 | SJB3-019A | 72 | 0.215693673039 | -0.7085 | 1.0151 | 0.2978 | -0.6932 | 2.6978 |
| BT-549 | Mitoxantrone | 72 | 0.0348124463112 | -0.5149 | 1.0122 | 0.0911 | -0.4314 | 0.6469 |
| MDA-MB-134-VI | b-AP15 | 72 | 0.130146410067 | -0.6081 | 1.0094 | 0.1596 | -0.5344 | 3.5592 |
| PDXHCI002 | Sepantronium | 72 | 0.0830755783448 | -0.5798 | 1.0081 | 0.1289 | -0.4748 | 1.5187 |
| PDX1328 | HY-50737A | 72 | 0.2644727784 | -0.8890 | 1.0078 | 0.4995 | -0.8567 | 1.5697 |
| MCF 10A | Mitoxantrone | 72 | 0.017667155736 | -0.2638 | 0.9981 | 0.0292 | -0.2233 | 0.7335 |
| HCC1428 | SJB3-019A | 72 | 0.367074889212 | -0.7873 | 0.9956 | 0.4852 | -0.7833 | 3.3771 |
| PDX1258 | Sepantronium | 72 | 0.0944990954 | -0.5758 | 0.9903 | 0.1955 | -0.5482 | 1.0184 |
| HCC1937 | HY-50737A | 72 | 0.0985106934226 | -0.4932 | 0.9863 | 0.1784 | -0.5076 | 1.1795 |
| SK-BR-3 | HY-50736 | 72 | 0.115680810144 | -0.4176 | 0.9862 | 0.1504 | -0.4466 | 2.4308 |
| MDA-MB-134-VI | SJB3-019A | 72 | 0.38974102992 | -0.8219 | 0.9800 | 0.5388 | -0.8154 | 2.9868 |
| HCC1937 | SJB3-019A | 72 | 0.22094135853 | -0.6386 | 0.9798 | 0.3369 | -0.6446 | 1.9637 |
| HCC1419 | SJB3-019A | 72 | 0.264021428661 | -0.7295 | 0.9719 | 0.3757 | -0.7072 | 2.4982 |